Phosphatidylinositol 4-kinases (PI4Ks) catalyze the production of phosphatidylinositol 4-phosphate (PI4P), a crucial intermediate in the production of membrane polyphosphoinositides, which control a variety of cellular processes. The trans-Golgi network (TGN) and the Golgi membranes are defined by PI4P, which also controls traffic to and from the Golgi. Based on enzymatic differences, two classes of PI4K have been distinguished termed Types II (PI4KII) and III (PI4KIII), and each of which contains α and β isoforms.
The biochemical characteristics of PI4KII alpha and beta are comparable. The soluble enzymes known as PI4KIIIs (α- and β-forms) share structural similarities with PI3-kinases and are susceptible to PI3-kinase inhibitors like Wortmannin. PtdIns 4-phosphate, an early key signaling molecule in the phosphatidylinositol cycle that is essential for T cell activation, is produced by PI4KIIs. A number of positive-sense RNA viruses depend on PI4KIIIs to produce their replication complexes (viral factories), making it a potential target for cutting-edge pan-viral therapeutics.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V3213 | BQR-695 (NVP-BQR695) | 1513879-21-4 | BQR-695 (previously known as BQR695 or NVP-BQR695) is apotent and selectivePI4KIIIβinhibitor with antimalarial activity. |
|
V54038 | EDI048 | 2767264-57-1 | EDI048 (compound 1.16) is an orally bioavailable Cryptosporidium PI4K inhibitor that may be utilized in cryptosporidiosis research. |
|
V3212 | KDU691 | 1513879-19-0 | KDU691 is a Plasmodium PI4 kinase (PI4K) inhibitor. |
|
V69242 | MIPS-21335 | 2569296-51-9 | MIPS-21335 is a PI3KC2α inhibitor (IC50= 0.007 μM). |
|
V4967 | PI4KIIIbeta-IN-10 | 1881233-39-1 | PI4KIIIβ-IN-10 (PI4KIIIbeta-IN-10) is a novel, potent and selective PI4KIIIβ (Type III phosphatidylinositol 4-kinase) inhibitor with an IC50of 3.6 nM with >1000-fold over class I and class III PI3Ks. |
|
V4965 | PI4KIIIbeta-IN-9 | 1429624-84-9 | PI4KIIIβ-IN-9 (PI4KIIIbeta-IN-9) is a novel, potent and selective PI4KIIIβ (Type III phosphatidylinositol 4-kinase) inhibitor with an IC50of 7 nM with >1000-fold over class I and class III PI3Ks. |
|
V27783 | UCB9608 | 1616413-96-7 | UCB9608 is a Potent, orally Bioavailable PI4KIIIβ Inhibitor. |
|
V35162 | UCT943 | 1450666-80-4 | UCT943 is a new generation Plasmodium falciparum PI4K inhibitor. |
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