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Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.

Ras related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Oxanthromicin V87119 (+)-Oxanthromicin 1616622-08-2 (+)-Oxanthromicin (Compound 1) can mislocalize oncogenic mutant K-Ras from the plasma membrane in intact Madin-Darby canine kidney (MDCK) cells, thereby exerting antitumor activity.
(1R)-KRAS inhibitor-24 V121309 (1R)-KRAS inhibitor-24 3030576-46-3 (1R)-KRAS inhibitor-24 is a pyridopyrimidine KRAS inhibitor with an IC50 of < 100 nM for KRas G12V, KRas WT and KRas G12R.
(4R)-BBO-8520 V110320 (4R)-BBO-8520 2893809-52-2 (4R)-BBO-8520 (compound 314) is an isomer of BBO-8520 and a selective KRASG12C inhibitor.
(R)-ACBI-4 V112413 (R)-ACBI-4 3097973-97-9 (R)-ACBI-4 is an isomer of ACBI-4.
(R)-G12Di-7 V103520 (R)-G12Di-7 2946593-60-6 (R)-G12Di-7 is a covalent ligand of KRAS-G12D and can selectively label K-Ras-G12D·GDP and K-Ras-G12D·GppNHp.
(R)-KRAS G12D inhibitor 28 hydrochloride dihydrate V116937 (R)-KRAS G12D inhibitor 28 hydrochloride dihydrate 3081520-70-6 (R)-KRAS G12D Inhibitor 28 Hydrochloride Dihydrate is the dihydrate of (R)-KRAS G12D Inhibitor 28.
(Rac)-Opnurasib V109064 (Rac)-Opnurasib 2653201-38-6 (Rac)-Opnurasib ((Rac)-JDQ-443; (Rac)-NVP-JDQ443) are racemic forms of Opnurasib.
(RS)-G12Di-1 V89591 (RS)-G12Di-1 (RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.
(S)-AZD0022 V118513 (S)-AZD0022 (S)-AZD0022 is an isomer of AZD0022, which is a selective orally active KRASG12D inhibitor.
(S)-JDQ-443 ((S)-NVP-JDQ443) V51415 (S)-JDQ-443 ((S)-NVP-JDQ443) 2653994-10-4 (S)-JDQ-443 is an isomer of JDQ-443 .
(S,R,S)-BBO-11818 V122259 (S,R,S)-BBO-11818 3029184-80-0 (S,R,S)-BBO-11818 is a KRAS inhibitor that can be used in cancer research.
(±)-Spiro-oxanthromicin A V117719 (±)-Spiro-oxanthromicin A 1616622-10-6 (±)-Spirocycloflavin A (compound 4) is a polyketide compound and a K-Ras inhibitor with an IC50 value of 26.7 μM.
2-羟基-1-萘甲醛 V51476 CFL-137 708-06-5 CFL-137 is a selective KRasG12C inhibitor.
4,6-二氯靛红 V51475 CFL-120 18711-15-4 CFL-120 is a selective KRasG12C inhibitor.
6-Thio-GTP tetrasodium V127486 6-Thio-GTP tetrasodium 6-Thio-GTP tetrasodium is a Vav1-Rac inhibitor.
8-CPT-2'-O-Me-cAMP V87108 8-CPT-2'-O-Me-cAMP 510774-50-2 8-CPT-2'-O-Me-cAMP is a Rap1 activator.
8-pHPT-2'-O-Me-cAMP V87118 8-pHPT-2'-O-Me-cAMP 612513-15-2 8-pHPT-2'-O-Me-cAMP is a cAMP analog and an Epac agonist.
ACBI-4 V120117 ACBI-4 3097985-19-5 ACBI-4 is a selective GTP-bound KRAS active state (KRAS(on)) PROTAC degrader.
ADT-007 V86758 ADT-007 1945941-09-2 ADT-007 is a potent, orally active pan-RAS inhibitor with strong anticancer effects.
ADT-1004 V128345 ADT-1004 1945941-72-9 ADT-1004 is the oral active prodrug of ADT-007.
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