The homodimeric aspartyl protease HIV protease, which cleaves proviral polyproteins to produce mature protein components necessary for the development of an infectious virus, is essential for the viral life cycle. In order to create the mature protein components of an infectious HIV virion, HIV protease cleaves newly synthesized polyproteins at the proper locations. When developing anti-retroviral medications to treat HIV/AIDS (acquired immune deficiency syndrome), HIV protease is a crucial drug target.
HIV-1 protease breaks down the polyproteins Gag and Gag-Pro-Pol to allow viral maturation. More than 12 different substrates are recognized and broken down, which causes viral maturation. Similar to HIV-1, HIV-2 protease is a homodimeric aspartyl enzyme that plays a crucial part in the HIV life cycle by processing the precursor polyproteins Gag and Gag-Pro-Pol, which results in viral maturation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V88269 | GS-9770 | 2306328-43-6 | GS-9770 is an orally available HIV protease inhibitor with a Ki of 0.16 nM. |
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V79791 | HIV Protease Substrate 1 TFA | HIV Protease Substrate 1 TFA is an exogenous HIV protease substrate that may be utilized to study the enzymatic activity of HIV protease. | |
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V83408 | HIV-1 protease-IN-13 | ||
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V79794 | HIV-1 protease-IN-3 | HIV-1 protease-IN-3 (compound 14) is a potent HIV-1 protease inhibitor (IC50=71 nM; EC50=0.86 μM). | |
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V88270 | Longipedunin A | 886441-72-1 | Longipedunin A is a HIV-1 protease inhibitor with an IC50 value of 50 µg/mL. |
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V88273 | NNRT-IN-3 | NNRT-IN-3 (Compound 8) is a HIV-1 non-nucleoside reverse transcriptase (NNRT) inhibitor (EC50=0.01 μM). | |
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V80960 | NNRTIs-IN-3 | NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (EC50=0.01 µM). | |
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V88271 | RK-682 | 150627-37-5 | RK-682 is an inhibitor of protein tyrosine phosphatase (PTPase), heparinase, phospholipase A2 and HIV-1 protease. |
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V88272 | RK-682 hemicalcium | 332131-32-5 | RK-682 hemicalcium is the calcium salt form of RK-682. |
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V12260 | Tenofovir disoproxil (GS 4331) | 201341-05-1 | Tenofovir disoproxil [Bis(POC)-PMPA; GS 4331)] is an antiretroviral drug and prodrug ofTenofovir, acting as anucleotide reverse transcriptase inhibitorto prevent and treat HIV/AIDS and to treat chronic hepatitis B. |
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V13833 | Fosamprenavir Calcium (GW433908G) | 226700-81-8 | Fosamprenavir Calcium (Amprenavir phosphate; GW-433908) is a phosphate ester prodrug of Amprenavir with improved solubility. |
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