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HIV Protease

HIV Protease

The homodimeric aspartyl protease HIV protease, which cleaves proviral polyproteins to produce mature protein components necessary for the development of an infectious virus, is essential for the viral life cycle. In order to create the mature protein components of an infectious HIV virion, HIV protease cleaves newly synthesized polyproteins at the proper locations. When developing anti-retroviral medications to treat HIV/AIDS (acquired immune deficiency syndrome), HIV protease is a crucial drug target.
HIV-1 protease breaks down the polyproteins Gag and Gag-Pro-Pol to allow viral maturation. More than 12 different substrates are recognized and broken down, which causes viral maturation. Similar to HIV-1, HIV-2 protease is a homodimeric aspartyl enzyme that plays a crucial part in the HIV life cycle by processing the precursor polyproteins Gag and Gag-Pro-Pol, which results in viral maturation.

HIV Protease related products

Structure Cat No. Product Name CAS No. Product Description
AG-1284 V116284 AG-1284 162054-18-4 AG-1284 is an HIV protease inhibitor with an EC50 value of 0.5 mg/mL.
Desthiazolylmethyl ritonavir V103134 Desthiazolylmethyl ritonavir 256328-82-2 Desthiazolylmethylritonavir is a base-catalyzed degradation product of the HIV protease inhibitor ritonavir.
DMP-851 V115910 DMP-851 188978-02-1 DMP-851 is a cyclic urea-based HIV protease inhibitor with a Ki value of 0.021 nM.
Elunonavir V99711 Elunonavir 2242428-57-3 Elunavir (GS-1156) is an HIV protease inhibitor with a high barrier to resistance and excellent metabolic stability.
GS-9770 V88269 GS-9770 2306328-43-6 GS-9770 is an orally available HIV protease inhibitor with a Ki of 0.16 nM.
HIV Protease Substrate 1 TFA V79791 HIV Protease Substrate 1 TFA HIV Protease Substrate 1 TFA is an exogenous HIV protease substrate that may be utilized to study the enzymatic activity of HIV protease.
HIV-1 Protease V119248 HIV-1 Protease HIV-1 protease is synthesized as part of a large Gag-Pol precursor protein.
HIV-1 protease-IN-13 V83408 HIV-1 protease-IN-13
HIV-1 protease-IN-3 V79794 HIV-1 protease-IN-3 HIV-1 protease-IN-3 (compound 14) is a potent HIV-1 protease inhibitor (IC50=71 nM; EC50=0.86 μM).
HIV-1-IN-88 V114750 HIV-1-IN-88 2459707-59-4 V-1-IN-88 (compound 20a) is a potent HIV-1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 value of 10.4 nM.
HIV-1-IN-91 V112145 HIV-1-IN-91 HIV-1-IN-91 (compound BAN) is an HIV-1 protease inhibitor.
Longipedunin A V88270 Longipedunin A 886441-72-1 Longipedunin A is a HIV-1 protease inhibitor with an IC50 value of 50 µg/mL.
NNRT-IN-3 V88273 NNRT-IN-3 NNRT-IN-3 (Compound 8) is a HIV-1 non-nucleoside reverse transcriptase (NNRT) inhibitor (EC50=0.01 μM).
NNRTIs-IN-3 V80960 NNRTIs-IN-3 NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (EC50=0.01 µM).
PAC-Phe-Val V110365 PAC-Phe-Val 3088543-72-7 PAC-Phe-Val is a potent HIV-1 protease inhibitor with an IC50 value of 33.10 nM.
RK-682 V88271 RK-682 150627-37-5 RK-682 is an inhibitor of protein tyrosine phosphatase (PTPase), heparinase, phospholipase A2 and HIV-1 protease.
RK-682 hemicalcium V88272 RK-682 hemicalcium 332131-32-5 RK-682 hemicalcium is the calcium salt form of RK-682.
SRI-32743 V119038 SRI-32743 1940118-42-2 SRI-32743 is an allosteric regulator of human dopamine transporter (hDAT) (IC50 = 9.86 μM).
Stercobilin hydrochloride (mixture of isomers) V97858 Stercobilin hydrochloride (mixture of isomers) 13129-80-1 Stercobilin hydrochloride (mixture of isomers) is a bile pigment metabolized by intestinal bacteria and an inhibitor of HIV protease with a Ki of 4 μM.
替诺福韦酯 V12260 Tenofovir disoproxil (GS 4331) 201341-05-1 Tenofovir disoproxil [Bis(POC)-PMPA; GS 4331)] is an antiretroviral drug and prodrug ofTenofovir, acting as anucleotide reverse transcriptase inhibitorto prevent and treat HIV/AIDS and to treat chronic hepatitis B.
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