The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V17416 | Alprenolol HCl | 13707-88-5 | Alprenolol HCl (alfeprol, alpheprol) is a potent and non-selective beta blocker as well as 5-HT1A receptor antagonist, used in the treatment of angina pectoris. |
|
V8349 | Atenolol | 29122-68-7 | Atenolol is a cardioselectiveβ1 receptor antagonist/blocker and an approved drug for hypertension and angina pectoris. |
|
V13028 | Boldine | 476-70-0 | Boldine is a naturally occurring alkaloid of the aporphine class isolated fromthe boldo tree and in Lindera aggregata. |
|
V17512 | Carazolol | 57775-29-8 | Carazolol is a potentβ1/β2 adrenoceptor antagonist used in the treatment of hypertension. |
|
V9823 | Doxazosin (UK 33274) | 74191-85-8 | Doxazosin (UK 33274), a quinazoline-derivative, potently and selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. |
|
V30593 | DSP-4 hydrochloride | 40616-75-9 | DSP-4 hydrochloride (Neurotoxin DSP 4) is a novel, potent, BBB-penetrant and highly selective neurotoxin with neurotoxic effects on noradrenergic neurons of adult and developing rats. |
|
V13734 | Metoprolol | 51384-51-1 | Metoprolol(Lanoc; Selopral; Ritmolol;Lopressor; Metomerck; Metop; Toprol) is a potent β1 adrenergicreceptor blocker and an approved drug for thetreatment of high blood pressure and chest pain. |
|
V9958 | Midodrine hydrochloride | 43218-56-0 | Midodrine hydrochloride (Amatine; Orvaten;Midodrine HCl; Pro-Amatine),the hydrochloride salt of midodrine which is aphenylalkanolamine derivative,is a potent adrenergic alpha-1 agonist thathas been found to be able toincrease arterial pressure, thus may beuseful in managing hypotensive conditions owing to their long lasting blood pressure increasing effects. |
|
V8325 | Olodaterol HCl | 869477-96-3 | Olodaterol HCl, the hydrochloride salt of Olodaterol (BI-1744; BI1744;STRIVERDI RESPIMAT), is a ultra-long acting β-adrenergic receptor agonist approved in 2014 as an inhalation for the treatment of patients with chronic obstructive pulmonary disease (COPD). |
|
V5976 | Ro 363 | 74513-77-2 | Ro 363 is a potent and selective beta 1-adrenoceptor agonist and an effective inotropic stimulant, as well as a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility. |
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V14281 | Salbutamol (AH-3365; Albuterol) | 18559-94-9 | Salbutamol (AH3365) is a potent, selective and short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. |
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