yingweiwo

Piezo Channel

Piezo Channel

Trimeric mechanosensitive ion channels called piezo channels open in response to mechanical stimuli like membrane stretch and shear stress, allowing positively charged ions like calcium to enter the cell. It is hypothesized that tension from lipid molecules in the cell membrane can be converted into extracellular mechanical stimuli to activate the Piezo channels. By using the lever principle, the intracellular beam may transfer lipid molecule tension from the distal blade to the central pore module, opening the central pore for ion-conducting.Piezo1 and Piezo2 are the two channel isoforms found in most vertebrates. The mechanotransduction pathways of touch perception, proprioception, nociception, vascular development, and breathing are all influenced by piezo1 and piezo2. Gain-of-function mutations in the Piezo1 gene have been associated with dehydrated hereditary stomatocytosis (DHS) in humans. Congenital lymphatic dysplasia14 and impaired proprioception and touch perception are all associated with loss-of-function mutations in the Piezo1 and Piezo2 genes.

Piezo Channel related products

Structure Cat No. Product Name CAS No. Product Description
D-GsMTx4 V79099 D-GsMTx4 D-GsMTx4, a spider peptide, is the D enantiomer of GsMTx4.
D-GsMTx4 TFA V79100 D-GsMTx4 TFA D-GsMTx4 TFA, a spider peptide, is the D enantiomer of GsMTx4.
Dooku1 (Yoda1 Analog) V31417 Dooku1 (Yoda1 Analog) 2253744-54-4 Dooku1, an analog of Yoda1, is a novel, potent and selective antagonist of the endogenous Piezo1 channel.
Yoda1 V5258 Yoda1 448947-81-7 Yoda 1 (GlyT2-IN-1) is a novel and potent agonist of Piezo1 which is the mechanotransduction channel.
Contact Us