The most prevalent proteins in the outer mitochondrial membrane (OMM), also referred to as mitochondrial porins, are VDAC (voltage-dependent anion selective channel) proteins. They are essential for a variety of cellular functions, including the control of metabolism and survival pathways. They ensure that mitochondrial complexes function properly and that energy is produced by mediating the exchange of ions (such as Ca2+) and metabolites (such as succinate or ATP, tRNA, or DNA) between mitochondria and the rest of the cell.
The three VDAC isoforms (VDAC1, VDAC2, and VDAC3) found in higher eukaryotes are each encoded by a unique gene found on a different chromosome. The use of VDAC in cancer and Alzheimer's disease research is possible.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4003 | DCPIB | 82749-70-0 | DCPIB (an ethacrynic acid derivative) is a novel, potent and selective blocker of the volume-sensitive anion channel (VSAC) on electrical activity and insulin secretion in rat pancreatic beta-cells. |
|
V38762 | NSC 15364 | 4550-72-5 | NSC 15364 is a VDAC1 oligomerization and apoptosis inhibitor. |
|
V34670 | VBIT-12 | 2089227-65-4 | This product is discontinued due to commercial reason. |
|
V2258 | VBIT-4 | 2086257-77-2 | VBIT-4 is a novel and potent inhibitor of VDAC1 (voltage-dependent anion channel 1), which is the outer mitochondrial membrane proteinand a convergence point for a variety of cell survival and death signals, including apoptosis. |
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V51417 | WEHI-9625 | 2595314-46-6 | WEHI-9625 is a first-of-its-kind, tricyclic contrast-enhancing small molecule kit with EC50 of 69 nM. |
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