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CRFR

CRFR

The G-coupled receptor superfamily includes the CRFR, also known as the corticotropin-releasing factor receptor (CRHR). There are two distinct receptor subtypes—CRF1 receptor and CRF2 receptor—as well as numerous splice variants for each receptor subtype. Urocortin 1 (Ucn 1) binds to both CRF1 and CRF2 receptors with high affinity, whereas CRF itself has a stronger affinity for CRF1 receptors.Urocortins 2 and 3 both preferentially bind to CRF2 receptors.

Two distinct genes that code for different subtypes of the CRF receptor exhibit a variety of alternative pre-mRNA splicing patterns, leading to a variety of variants resulting from partial or complete exon deletions or insertions. Regarding the nine human CRF1 isoforms (CRF1a-i) that have been described, CRF1a is the primary functional wild-type receptor, whereas the other isoforms may modulate CRF signaling. Three functionally active splice variants of the CRF2, designated CRF2a-c, have been identified in humans.

CRFR related products

Structure Cat No. Product Name CAS No. Product Description
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) V74557 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 150646-45-0 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist.
[DPro5] Corticotropin Releasing Factor, human, rat V74558 [DPro5] Corticotropin Releasing Factor, human, rat 195628-97-8 [DPro5] Corticotropin Releasing Factor, human, rat is a selective agonist of corticotropin releasing factor/hormone R2.
[DPro5] Corticotropin Releasing Factor, human, rat TFA V77343 [DPro5] Corticotropin Releasing Factor, human, rat TFA [DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective agonist of corticotropin-releasing factor/hormone R2 (CRH-R2).
[Met(O)21] Corticotropin Releasing Factor, ovine V77482 [Met(O)21] Corticotropin Releasing Factor, ovine [Met(O)21] Corticotropin Releasing Factor, ovine is corticotropin-releasing factor (CRF) obtained from sheep hypothalamus extract.
Antalarmin hydrochloride V74553 Antalarmin hydrochloride 220953-69-5 Antalarmin ( HCl) is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist (inhibitor) with a Ki of 1 nM.
BMS-561388 benzenesulfonate V116057 BMS-561388 benzenesulfonate 383368-51-2 BMS-561388 benzyl sulfonate is a corticotropin-releasing factor receptor (CRFR) antagonist.
Cortagine V77142 Cortagine Cortagine is a selective corticotropin-releasing factor receptor subtype 1 (CRF1) agonist/activator with EC50 for rCRF1 of 2.6 nM.
CP376395 V3997 CP376395 175140-00-8 CP 376395 is a novel potent, selective and orally bioactive antagonist of Corticotropin releasing factor 1 (CRF1) receptor.
CRF(6-33)(human) V74555 CRF(6-33)(human) 120066-38-8 CRF(6-33)(human) is a CRF-binding protein ligand (CRF-BP) inhibitor that competitively binds to CRF-BP but does not bind to postsynaptic CRF receptors.
CRF(6-33)(human) TFA V78883 CRF(6-33)(human) TFA CRF(6-33)(human) TFA is a CRF-binding protein ligand (CRF-BP) inhibitor that competitively binds to CRF-BP but does not bind to postsynaptic CRF receptors.
CRF, bovine TFA (Corticotropin Releasing Factor bovine TFA) V77136 CRF, bovine TFA (Corticotropin Releasing Factor bovine TFA) CRF, bovine (TFA) is a potent CRF receptor agonist that can replace [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
CRHR1 antagonist 1 V103218 CRHR1 antagonist 1 276890-57-4 CRHR1 antagonist 1 (compound 10a) is a non-peptide corticotropin-releasing hormone type I receptor (CRHR1) antagonist.
DMP 904 V116242 DMP 904 202579-74-6 DMP 904 is a non-competitive, fully antagonistic adrenocorticotropic hormone-releasing factor receptor (CRFR) antagonist.
K41498 V74556 K41498 434938-41-7 K41498 is a selective CRF2 receptor antagonist (inhibitor) with Kis of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively.
NBI 35965 hydrochloride V84665 NBI 35965 hydrochloride 1782228-59-4
Sauvagine TFA V76530 Sauvagine TFA Sauvagine TFA, a 40-amino acid (AA) neuropeptide extracted from frog skin, is a mammalian CRF agonist.
SN003 V74560 SN003 197801-88-0 SN003 is a reversible antagonist (IC50 = 241 nM) of corticotropin-releasing factor receptor 1 (CRFR 1), more than 1000-fold more potent than CRFR 2 antagonism.
Stresscopin (human) V119735 Stresscopin (human) 352020-03-2 Stresscopin (human) is a selective ligand for type 2 corticotropin-releasing hormone (CRH) receptors and can be used in research on stress-related diseases.
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) V81450 Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor selective agonist/activator with Ki of 1.7 nM.
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA) V81451 Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA) Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist/activator with Ki of 1.7 nM.
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