The G-coupled receptor superfamily includes the CRFR, also known as the corticotropin-releasing factor receptor (CRHR). There are two distinct receptor subtypes—CRF1 receptor and CRF2 receptor—as well as numerous splice variants for each receptor subtype. Urocortin 1 (Ucn 1) binds to both CRF1 and CRF2 receptors with high affinity, whereas CRF itself has a stronger affinity for CRF1 receptors.Urocortins 2 and 3 both preferentially bind to CRF2 receptors.
Two distinct genes that code for different subtypes of the CRF receptor exhibit a variety of alternative pre-mRNA splicing patterns, leading to a variety of variants resulting from partial or complete exon deletions or insertions. Regarding the nine human CRF1 isoforms (CRF1a-i) that have been described, CRF1a is the primary functional wild-type receptor, whereas the other isoforms may modulate CRF signaling. Three functionally active splice variants of the CRF2, designated CRF2a-c, have been identified in humans.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74557 | (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) | 150646-45-0 | (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. |
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V74558 | [DPro5] Corticotropin Releasing Factor, human, rat | 195628-97-8 | [DPro5] Corticotropin Releasing Factor, human, rat is a selective agonist of corticotropin releasing factor/hormone R2. |
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V77343 | [DPro5] Corticotropin Releasing Factor, human, rat TFA | [DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective agonist of corticotropin-releasing factor/hormone R2 (CRH-R2). | |
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V77482 | [Met(O)21] Corticotropin Releasing Factor, ovine | [Met(O)21] Corticotropin Releasing Factor, ovine is corticotropin-releasing factor (CRF) obtained from sheep hypothalamus extract. | |
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V74553 | Antalarmin hydrochloride | 220953-69-5 | Antalarmin ( HCl) is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist (inhibitor) with a Ki of 1 nM. |
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V77142 | Cortagine | Cortagine is a selective corticotropin-releasing factor receptor subtype 1 (CRF1) agonist/activator with EC50 for rCRF1 of 2.6 nM. | |
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V3997 | CP376395 | 175140-00-8 | CP 376395 is a novel potent, selective and orally bioactive antagonist of Corticotropin releasing factor 1 (CRF1) receptor. |
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V74555 | CRF(6-33)(human) | 120066-38-8 | CRF(6-33)(human) is a CRF-binding protein ligand (CRF-BP) inhibitor that competitively binds to CRF-BP but does not bind to postsynaptic CRF receptors. |
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V78883 | CRF(6-33)(human) TFA | CRF(6-33)(human) TFA is a CRF-binding protein ligand (CRF-BP) inhibitor that competitively binds to CRF-BP but does not bind to postsynaptic CRF receptors. | |
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V77136 | CRF, bovine TFA (Corticotropin Releasing Factor bovine TFA) | CRF, bovine (TFA) is a potent CRF receptor agonist that can replace [125I-Tyr]ovine CRF with a Ki of 3.52 nM. | |
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V74556 | K41498 | 434938-41-7 | K41498 is a selective CRF2 receptor antagonist (inhibitor) with Kis of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. |
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V3522 | Pexacerfont | 459856-18-9 | Pexacerfont (formerly known as BMS-562086) is a novel potent, selective and orally bioactive antagonist of corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor. |
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V76530 | Sauvagine TFA | Sauvagine TFA, a 40-amino acid (AA) neuropeptide extracted from frog skin, is a mammalian CRF agonist. | |
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V74560 | SN003 | 197801-88-0 | SN003 is a reversible antagonist (IC50 = 241 nM) of corticotropin-releasing factor receptor 1 (CRFR 1), more than 1000-fold more potent than CRFR 2 antagonism. |
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V81450 | Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) | Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor selective agonist/activator with Ki of 1.7 nM. | |
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V81451 | Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA) | Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist/activator with Ki of 1.7 nM. | |
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V74559 | Urocortin II, human | 351999-18-3 | Urocortin II (human) is a selective endogenous peptide agonist of type 2 corticotropin-releasing factor (CRF2) receptor and was used to study the role of CRF2 receptor in feeding behavior. |
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V80081 | Urocortin II, human TFA | Urocortin II, human (TFA) is a selective endogenous peptide agonist of type 2 corticotropin-releasing factor (CRF2) receptor and was used to study the role of CRF2 receptor in feeding behavior. | |
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V76385 | Urocortin III, mouse TFA | Urocortin III, mouse TFA is a related peptide of corticotropin-releasing factor (CRF). | |
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V81690 | Urotensin I TFA (Catostomus urotensin I TFA) | Urotensin I (Catostomus urotensin I) TFA is a CRF-like peptide that could be utilized as a CRF receptor agonist. |
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