CRFR

CRFR

The G-coupled receptor superfamily includes the CRFR, also known as the corticotropin-releasing factor receptor (CRHR). There are two distinct receptor subtypes—CRF1 receptor and CRF2 receptor—as well as numerous splice variants for each receptor subtype. Urocortin 1 (Ucn 1) binds to both CRF1 and CRF2 receptors with high affinity, whereas CRF itself has a stronger affinity for CRF1 receptors.Urocortins 2 and 3 both preferentially bind to CRF2 receptors.

Two distinct genes that code for different subtypes of the CRF receptor exhibit a variety of alternative pre-mRNA splicing patterns, leading to a variety of variants resulting from partial or complete exon deletions or insertions. Regarding the nine human CRF1 isoforms (CRF1a-i) that have been described, CRF1a is the primary functional wild-type receptor, whereas the other isoforms may modulate CRF signaling. Three functionally active splice variants of the CRF2, designated CRF2a-c, have been identified in humans.

CRFR related products

Structure Cat No. Product Name CAS No. Product Description
V74557 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 150646-45-0
V74558 [DPro5] Corticotropin Releasing Factor, human, rat 195628-97-8
V77343 [DPro5] Corticotropin Releasing Factor, human, rat TFA
V77482 [Met(O)21] Corticotropin Releasing Factor, ovine
V74553 Antalarmin hydrochloride 220953-69-5
V77142 Cortagine
V3997 CP376395 175140-00-8 CP 376395 is a novel potent, selective and orally bioactive antagonist of Corticotropin releasing factor 1 (CRF1) receptor.
V74555 CRF(6-33)(human) 120066-38-8
V78883 CRF(6-33)(human) TFA
V77136 CRF, bovine TFA (Corticotropin Releasing Factor bovine TFA)
V74556 K41498 434938-41-7
V3522 Pexacerfont 459856-18-9 Pexacerfont (formerly known as BMS-562086) is a novel potent, selective and orally bioactive antagonist of corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.
V76530 Sauvagine TFA
V74560 SN003 197801-88-0
V81450 Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41))
V81451 Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA)
V74559 Urocortin II, human 351999-18-3
V80081 Urocortin II, human TFA
V76385 Urocortin III, mouse TFA
V81690 Urotensin I TFA (Catostomus urotensin I TFA)
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