TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70122 | (1S,2S)-ML-SI3 ((+)-trans-ML-SI3) | 2563870-87-9 | (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3 and is a TRPML inhibitor. |
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V70167 | (R)-Methanandamide (AM-356) | 157182-49-5 | (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist/activator with a Ki of 20 nM. |
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V70142 | (Rac)-Dalzanemdor | 2216703-16-9 | This product is discontinued due to commercial reason. (Rac)-Dalzanemdor is an isomer of Dalzanemdor. |
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V84985 | (S)-ABT-102 | 808756-70-9 | |
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V7720 | Zucapsaicin (Civamide; cis-Capsaicin) | 25775-90-0 | Zucapsaicin (Civamide; cis-Capsaicin) is the cis isomer of capsaicin which is an orally bioactive TRPV1 agonist and a medication used to treat osteoarthritis of the knee and other neuropathic pain. |
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V0023 | HC-030031 (TOSLAB-829227) | 349085-38-7 | HC-030031 (also known as TOSLAB 829227)is a novel, potent and selective blocker/antagonist/inhibitor of TRPA1 (transient receptor potential ankyrin 1) channel. |
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V81847 | 2-(2-Methylbenzamido)acetic acid-d7 (2-methylhippuric acid d7) | 1216430-90-8 | 2-(2-Methylbenzamido)acetic acid-d7 is the deuterium labelled form of 2-(2-Methylbenzamido)acetic acid. |
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V70119 | 4-(Phenyldiazenyl)benzoic acid | 1562-93-2 | 4-(Phenyldiazenyl)benzoic acid is a photosensitive and controllable TRPA1 agonist that could be utilized as a pharmacological tool to study pain signaling. |
![4-[3-(三氟甲基)-2-吡啶基]-N-[5-(三氟甲基)-2-吡啶基]-1-哌嗪甲酰胺](http://www.invivochem.com/upload/1124/V4502.png)
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V4502 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a novel, potent, reversible, competitive and selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
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V4004 | ML204 | 5465-86-1 | ML204 is a novel, potent, and selective TRPC4 (Transient receptor potential canonical) channel inhibitor identified from high throughput fluorescent screen of 305,000 compounds of the Molecular Libraries Small Molecule Repository for inhibitors that blocked intracellular Ca(2+) rise in response to stimulation of mouse TRPC4β by μ-opioid receptors. |
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V70162 | 5-Iodoresiniferatoxin (I-RTX) | 535974-91-5 | 5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist (inhibitor) with IC50 of 0.7 and 5.4 nM for rat and human receptors, respectively. |
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V70152 | 6'-Iodoresiniferatoxin (6'-IRTX) | 335151-55-8 | 6'-Iodoresiniferatoxin (6'-IRTX) is a TRPV1 agonist that may be utilized in the research/study of neuropathic pain. |
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V92298 | 8-Br-7-CH-ADPR | 1011457-95-6 | 8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. |
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V6545 | A-967079 | 1170613-55-4 | A-967079 is a novel, potent, CNS-penetrant and selective blocker/antagonist TRPA1 channel (IC50s of 67 nM and 289 nM at human and rat TRPA1 receptors), with analgesic and antiinflammatory effects and is used in scientific research, but has not been developed for medical use. |
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V10018 | AC1903 | 831234-13-0 | AC1903 is a selective and specific inhibitor of TRPC5 with podocyte protective properties. |
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V6706 | AM-0902 | 1883711-97-4 | AM-0902 is a novel, potent and selective Transient Receptor Potential A1 (TRPA1) antagonist withIC50s of 71 and 131 nM forrTRPA1andhTRPA1, respectively. |
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V3458 | AMG 333 | 1416799-28-4 | AMG 333 is a novel, potent and highly selectiveTRPM8antagonist with anIC50of 13 nMand 20 nM for hTRPM8 and rTRPM8, respectively. |
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V3400 | AMG 9810 | 545395-94-6 | AMG9810 (AMG-9810) is a nove, potent, selective and competitive antagonist of vanilloid receptor 1 (TRPV1) with cancer-promoting effects. |
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V6811 | ASP7663 | 1190217-35-6 | ASP7663 is an selective and orally bioavailable TRPA1 activator, acting by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo. |
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V70123 | BAY-390 | 2741956-55-6 | BAY-390 is a selective, cross-species active, brain-penetrating TRPA1 inhibitor. |
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