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TRP Channel

TRP Channel

TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.

TRP Channel related products

Structure Cat No. Product Name CAS No. Product Description
(1S,2S)-ML-SI3 ((+)-trans-ML-SI3) V70122 (1S,2S)-ML-SI3 ((+)-trans-ML-SI3) 2563870-87-9 (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3 and is a TRPML inhibitor.
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide V121738 (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 1309389-73-8 (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is a chemically synthesized fragrance commonly found in toothpaste products.
(E)-8-Methyl-6-nonenoic acid V107067 (E)-8-Methyl-6-nonenoic acid 59320-77-3 (E)-8-Methyl-6-nonenoic acid is a thermal degradation product of capsaicin.
(R)-Isosakuranetin V121934 (R)-Isosakuranetin 221362-74-9 (R)-Isosakuranetin is an isomer of isoprimordin.
(R)-Methanandamide (AM-356) V70167 (R)-Methanandamide (AM-356) 157182-49-5 (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist/activator with a Ki of 20 nM.
(S)-ABT-102 V84985 (S)-ABT-102 808756-70-9
(S)-AMG-628 V104775 (S)-AMG-628 862269-92-9 (S)-AMG-628 (Compound 16q) is the S isomer of AMG-628.
(Z)-辣椒素 V7720 Zucapsaicin (Civamide; cis-Capsaicin) 25775-90-0 Zucapsaicin (Civamide; cis-Capsaicin) is the cis isomer of capsaicin which is an orally bioactive TRPV1 agonist and a medication used to treat osteoarthritis of the knee and other neuropathic pain.
17(R)-Resolvin D1 V102858 17(R)-Resolvin D1 528583-91-7 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-induced epimer of Resolvin D1 that exhibits anti-inflammatory activity in both mouse and human PMNS cells.
18:0-PhoDAG V123413 18:0-PhoDAG 1985595-31-0 18:0-PhoDAG is a photo-switchable diacylglycerol (DAG) that can rapidly photoactivate these DAG-sensitive TRP channels.
2′-Deoxy-ADPR V101444 2′-Deoxy-ADPR 111864-49-4 2′-deoxy-ADPR is an agonist of the transient receptor potential melanin 2 channel (TRPM2 channel).
2'-Deoxyadenosine-5'-O-diphosphoribose sodium V124611 2'-Deoxyadenosine-5'-O-diphosphoribose sodium 2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a TRPM2 agonist.
2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 V0023 HC-030031 (TOSLAB-829227) 349085-38-7 HC-030031 (also known as TOSLAB 829227)is a novel, potent and selective blocker/antagonist/inhibitor of TRPA1 (transient receptor potential ankyrin 1) channel.
2-(2-Methylbenzamido)acetic acid-d7 (2-methylhippuric acid d7) V81847 2-(2-Methylbenzamido)acetic acid-d7 (2-methylhippuric acid d7) 1216430-90-8 2-(2-Methylbenzamido)acetic acid-d7 is the deuterium labelled form of 2-(2-Methylbenzamido)acetic acid.
3,3-Azo-1-butanol V125046 3,3-Azo-1-butanol 25055-82-7 3,3-Azo-1-butanol is an orally effective hypoglycemic agent.
4-(Phenyldiazenyl)benzoic acid V70119 4-(Phenyldiazenyl)benzoic acid 1562-93-2 4-(Phenyldiazenyl)benzoic acid is a photosensitive and controllable TRPA1 agonist that could be utilized as a pharmacological tool to study pain signaling.
4-[3-(三氟甲基)-2-吡啶基]-N-[5-(三氟甲基)-2-吡啶基]-1-哌嗪甲酰胺 V4502 JNJ-17203212 821768-06-3 JNJ-17203212 is a novel, potent, reversible, competitive and selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
4-甲基-2-(1-哌啶基)-喹啉 V4004 ML204 5465-86-1 ML204 is a novel, potent, and selective TRPC4 (Transient receptor potential canonical) channel inhibitor identified from high throughput fluorescent screen of 305,000 compounds of the Molecular Libraries Small Molecule Repository for inhibitors that blocked intracellular Ca(2+) rise in response to stimulation of mouse TRPC4β by μ-opioid receptors.
5-Iodoresiniferatoxin (I-RTX) V70162 5-Iodoresiniferatoxin (I-RTX) 535974-91-5 5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist (inhibitor) with IC50 of 0.7 and 5.4 nM for rat and human receptors, respectively.
6'-Iodoresiniferatoxin (6'-IRTX) V70152 6'-Iodoresiniferatoxin (6'-IRTX) 335151-55-8 6'-Iodoresiniferatoxin (6'-IRTX) is a TRPV1 agonist that may be utilized in the research/study of neuropathic pain.
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