Bmx is a non-receptor tyrosine kinase belonging to the Tec kinase family.The protein has a SH2 domain that binds to tyrosine-phosphorylated proteins and participates in signal transduction as well as a PH-like domain that mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3). The protein controls the differentiation and tumorigenicity of several different types of cancer cells and is involved in a number of signal transduction pathways, including the Stat pathway. Phosphatidylinositol 3-kinase's downstream effector, Bmx, has been demonstrated to have an N-terminal pleckstrin homology domain. The development of breast cancer cells has been linked to P21-activated kinase 1 (Pak1), another well-known phosphatidylinositol 3-kinase effector.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V130419 | BMX-IN-3 | 2657662-64-9 | BMX-IN-3 is an irreversible and selective BMX inhibitor with an IC50 value of 12 nM. |
|
V130644 | Brefeldin A 4-O-nicotinate | 3035018-34-6 | Brefeldin A 4-O-nicotinate is a dual inhibitor of Arf1 and BMX proteins. |
|
V2990 | CHMFL-BMX-078 | 1808288-51-8 | CHMFL-BMX-078 is a highly potent and selective type II irreversible/covalent kinase inhibitor of BMX (bone marrow kinase on chromosome X) kinase with an IC50 of 11 nM. |
|
V137851 | IHMT-15130 | IHMT-15130 is a highly potent, irreversible BMX kinase inhibitor (IC50 = 1.47 nM). | |
|
V137852 | IHMT-15137 | IHMT-15137 is a BMX inhibitor with an IC50 value of 26.97 nM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
