AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V9698 | 6-Gingerol | 23513-14-6 | [6]-Gingerol is an active substance extracted from ginger that has a variety of bioactivities like anti-cancer, anti~inflammatory, and antioxidant. |
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V0244 | A-769662 | 844499-71-4 | A-769662 (A769662;A 769662), a thienopyridone analog, is a potent, alloesteric and reversible activator of AMPK (AMP-activated protein kinase)with antidiabetic activity. |
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V0245 | Acadesine (AICAR; NSC-105823) | 2627-69-2 | Acadesine (also known as NSC105823,AICA-riboside, and AICAR) is a novel and potent AMPK (AMP-activated protein kinase) activatorwith potential antitumor and antidiabetic activity. |
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V6440 | Bempedoic acid (ESP55016; ETC1002) | 738606-46-7 | Bempedoic acid (formerly ESP-55016; ETC-1002; ESP55016; ETC1002;Nexletol;Bempedoate) is an ATP-citrate lyase (ACL) inhibitor as well as an activator of hepatic AMP-activated protein kinase (AMPK). |
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V11178 | Buformin | 692-13-7 | Buformin (NSC-528218; 1-butylbiguanide) is an orally bioavailableAMPKactivator approved for use as anantidiabetic drug. |
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V0251 | Dorsomorphin (BML275) | 866405-64-3 | Dorsomorphin(BML-275) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. |
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V0246 | Dorsomorphin 2HCl (BML275) | 1219168-18-9 | Dorsomorphin 2HCl (formerly BML-275 dihydrochloride) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor thatinhibits AMPK with a Ki of 109 nM in cell-free assays, exhibiting little inhibition against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. |
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V3967 | EX-229 | 1219739-36-2 | EX229 (EX-229; AMPK Activator 991), a benzimidazole analog, is a novel, potent and allosteric AMPK (AMP-activated protein kinase) activator with Kd values of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively. |
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V0249 | GSK621 | 1346607-05-3 | GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity. |
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V0250 | HTH-01-015 | 1613724-42-7 | HTH-01-015 is a novel, potent and selective inhibitor of NUAK1( (NUAK family SnF1-like kinase-1)which can serve as useful chemical probes to delineate the biological roles of the NUAK kinases. |
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V40864 | Lixumistat (IM156) | 1422365-93-2 | IM156 (IM-156; IM 156;HL-156A;HL156A) is a metformin/biguanideanalogwith potential anticancer and neuroprotective activity. |
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V4058 | MK-3903 | 1219737-12-8 | MK-3903 (MK3903) is a novel, potent and selectiveAMPK (AMP-activated protein kinase)activator with EC50 of 8 nM for α1 β1 γ1 subunit,leading to improved lipid metabolism and insulin sensitization in mice. |
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V4287 | MK8722 | 1394371-71-1 | MK-8722 (MK8722) is a novel, potent allostericpan-AMPK activator with anti-diabetic effects. |
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V12775 | Nilotinib HCl hydrate | 923288-90-8 | Nilotinib HCl hydrate (formerly also known asAMN-107, AMN107 HCl hydrate) is a potent, orally bioavailable aminopyrimidine-derivative Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. |
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V33389 | O-304 | 1261289-04-6 | O-304 is a first-in-class, orally bioavailable pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. |
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V3110 | PF-06409577 | 1467057-23-3 | PF-06409577 (PF06409577) is a potent, selective, orally bioavailable, allosteric activator ofAMPKα1β1γ1 (5′ adenosine monophosphate-activated protein kinase) with the potential to be used for diabetic nephropathy. |
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V0247 | Phenformin HCl (ST50409947; D08352; W104144) | 834-28-6 | Phenformin HCl (ST-50409947; D-08352; W-104144), the hydrochloride salt of phenformin, was a marketed anti-diabetic drug ofthe biguanide class, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis. |
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V33400 | TMPA | 1258275-73-8 | TMPA is a high-affinity Nur77 antagonist, and binding to Nur77 results in the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. |
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V0248 | WZ4003 | 1214265-58-3 | WZ4003 is a novel, potent and highly specific inhibitor of NUAK kinases. |
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