It is possible to actively transport sodium, potassium, and chloride into and out of cells with the help of the protein NKCC (Na-K-Cl cotransporter). This membrane transport protein comes in two forms, NKCC1 and NKCC2, but they are not isoforms because they are produced by two different genes, SLC12A2 and SLC12A1, respectively. The final gene product of the NKCC1/Slc12a2 gene either retains (isoform 1) or skips (isoform 2) exon 21.NKCC1 is widely distributed throughout the body and plays crucial roles in fluid-secreting organs. The kidney is the only location where NKCC2 is found, and it works to draw sodium, potassium, and chloride from urine so that they can be reabsorbed into the blood. Sodium (Na), potassium (K), and chloride (Cl) ions are transported across cell membranes by membrane transport proteins known as NKCC proteins. NKCC proteins are symporters since they all transport solutes in the same direction.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4488 | Bumetanide | 28395-03-1 | Bumetanide (also known as Ro 10-6338; PF-1593) is a novel and potent inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM. |
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