NKCC

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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NKCC

It is possible to actively transport sodium, potassium, and chloride into and out of cells with the help of the protein NKCC (Na-K-Cl cotransporter). This membrane transport protein comes in two forms, NKCC1 and NKCC2, but they are not isoforms because they are produced by two different genes, SLC12A2 and SLC12A1, respectively. The final gene product of the NKCC1/Slc12a2 gene either retains (isoform 1) or skips (isoform 2) exon 21.NKCC1 is widely distributed throughout the body and plays crucial roles in fluid-secreting organs. The kidney is the only location where NKCC2 is found, and it works to draw sodium, potassium, and chloride from urine so that they can be reabsorbed into the blood. Sodium (Na), potassium (K), and chloride (Cl) ions are transported across cell membranes by membrane transport proteins known as NKCC proteins. NKCC proteins are symporters since they all transport solutes in the same direction.

NKCC related products

Cat No.	Product Name	CAS No.	Product Description
V129994	Bendroflumethiazide-d7		Bendroflumethiazide-d7 is a deuterium-labeled bendroflumethiazide.
V131042	Carbonic anhydrase inhibitor 32		Carbonic anhydrase inhibitor 32 is an orally effective selective hCA II/VII inhibitor with Ki values of 6.3 nM, 10.1 nM, and 681 nM for hCA II, hCA VII, and hCA I, respectively.
V137738	IAMA-6	2497525-96-7	IAMA-6 is a selective NKCC1 inhibitor with neuroprotective effects.
V104872	KCC2 potentiators-1	3058906-46-7	KCC2 potentiator-1 (compound 2) is a potassium chloride cotransporter-2 (KCC2) potentiator.
V146460	Triflocin	13422-16-7	Triflocin is an orally effective diuretic and sodium-potassium-chloride cotransporter inhibitor with an IC50 value of 3 × 10⁻⁵ M.
V4488	Bumetanide	28395-03-1	Bumetanide (also known as Ro 10-6338; PF-1593) is a novel and potent inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.