Mitophagy is the selective degradation of mitochondria by autophagy.
The vital organelles known as mitochondria control the homeostasis of cellular energy and cell death. Therefore, it is essential for preserving healthy cellular processes that damaged mitochondria are eliminated through autophagy, also known as mitophagy. In fact, it has recently been suggested that mitophagy is essential for neurodegenerative diseases, ischemia- or drug-induced tissue injury, paternal mitochondrial degradation, red blood cell terminal differentiation, and other processes.
Mitophagy and autophagy are crucial cellular processes that break down the contents of cells, conserve energy, and prevent the buildup of broken and aggregated biomolecules.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V94210 | Metformin (glycinate) | 121369-64-0 | Glycine metformin inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. |
|
V75785 | MTX115325 | 2750895-97-5 | MTX115325 (Example 1) is an orally bioavailable, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuro-protection activity. |
|
V88567 | PARL-IN-1 TFA | PARL-IN-1 TFA is a potent PARL inhibitor with IC50 of 28 nM. | |
|
V93711 | Rosolutamide | 1039760-91-2 | Rosolutamide (ASC-JM17), a curcumin analog, is an orally active Nrf1 and Nrf2 activator. |
|
V88573 | T-271 | 1005775-58-5 | T-271 is a selective mitophagy inducer. |
|
V25573 | Mitochonic Acid 5 | 1354707-41-7 | Mitochonic acid 5 binds to mitochondria and improves renal tubular and cardiomyocyte damage. |
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