An essential nuclear protein export receptor known as CRM1 (Chromosome Region Maintenance 1; Exportin 1; XPO1), which belongs to the karyopherin family of transport receptors, recognizes hydrophobic, leucine-rich nuclear export signals (NES) and transports target proteins across a Ran-GTP gradient. Numerous cargo proteins, including transcription factors, tumor suppressor proteins (TSPs), cell-cycle regulators like p53, p21, p27, nucleophosmin 1 (NPM1), and RNA molecules are actively transported by CRM1.

Multiple consequences that can cause cancer can result from abnormal CRM1 upregulation. More growth regulatory proteins, like c-myc or BCR-ABL, could be transported into the cytoplasm and activate downstream signaling, resulting in sustained cell proliferation, if CRM1 were to be upregulated. Similar to Rb, p53, p21, or p27, tumor suppressor proteins (TSPs) are functionally inactivated upon export, removing the brake on uncontrollable cell growth. Apoptosis, DNA damage repair, chromosomal stabilization, and angiogenesis are just a few examples of processes that would be affected in a similar way. As a result, the therapeutic target of CRM1 activity inhibition became appealing.

CRM1 related products

Structure Cat No. Product Name CAS No. Product Description
CRM1-IN-1 V78397 CRM1-IN-1 CRM1-IN-1 (Compound KL1) is a non-covalent CRM1 inhibitor.
CRM1-IN-2 V78399 CRM1-IN-2 CRM1-IN-2 (Compound KL2) is a non-covalent CRM1 inhibitor.
CRM1-IN-3 V85410 CRM1-IN-3 1114628-25-9
Eltanexor (KPT-8602) V20471 Eltanexor (KPT-8602) 1642300-52-4 Eltanexor (is discontinued) formerly known as KPT-8602, is a second-generation exportin-1 inhibitor.
Selinexor (KPT-330) V1589 Selinexor (KPT-330) 1393477-72-9 This product has been discontinued.
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