A molecule known as a DNA alkylator or crosslinker can alkylate DNA or form a crosslink with DNA. The effects of a DNA alkylator or crosslinker can be mutagenic, therapeutic, or other. Transferring an alkyl group from one molecule to another is known as alkylation. The alkyl group can be transferred as a free radical, a carbanion, a carbene, or an alkyl carbocation.Alkyl groups are probably the most frequent group found in organic molecules, so alkylating agents are frequently used in chemistry. When there isn't a readily accessible biological precursor, selective alkylation—adding pieces of the chain with the desired functional groups—is used. Methylation is the name for alkylation with one carbon. Chemotherapy in medicine employs DNA alkylation to harm cancer cells' DNA. Alkylating antineoplastic agents are a class of medications that cause alkylation.When different exogenous or endogenous agents react with two different positions in the DNA, crosslinking of the DNA results. This can happen within the same strand of the DNA (intrastrand crosslink) or between the DNA strands (interstrand crosslink). Protein and DNA can crosslink with one another. Crosslinks prevent DNA from replicating, which stops replication and results in cell death if the crosslink is not repaired. The RAD51 family is involved in maintenance.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V77442 | (Rac)-Melphalan-d8 | (Rac)-Melphalan-d8 is a deuterium labelled form of Melphalan. | |
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V52948 | 2-Iodoacetamide (iodoacetamide; Iodoacetamide) | 144-48-9 | 2-Iodoacetamide (Iodoacetamide) is a commonly used alkylating agent that is used to alkylate cysteine in the process of preparing proteomics samples. |
|
V56576 | 2-Iodoacetamide-d4 (Iodoacetamide-d4) | 1219802-64-8 | 2-Iodoacetamide-d4 is the deuterated form of 2-Iodoacetamide. |
|
V2028 | Altretamine (ENT-50852) | 645-05-6 | Altretamine (also known as Hexamethylmelamine, NSC13875, ENT50852, WR-95704) is an alkylating anticancer drug which also acts as a chemosterilant for male houseflies and other insects. |
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V55758 | Anticancer agent 11 | 2332936-95-3 | anti-cancer compound 11 is a broad spectrum (a wide range) anti-cancer compound that can inhibit angiogenesis and induces DNA cross-linking. |
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V51722 | ASTA-6496 (4-Hydroperoxy cyclophosphamide) | 39800-16-3 | 4-Hydroperoxy cyclophosphamide, active metabolite form of the proagent Cyclophosphamide. |
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V78368 | Bendamustine-d4 (SDX-105-d4 (free base)) | Bendamustine-d4 is the deuterium labelled form of Bendamustine. | |
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V5078 | Busulfan (Myleran, Busulfex) | 55-98-1 | Busulfan (Myleran; Busulfex IV) is a potent DNA alkylating agent with selective immunosuppressive effect on bone marrow. |
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V50952 | Busulfan-D8 | 116653-28-2 | Busulfan-d8 is a deuterated form of Busulfan. |
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V80524 | Chlorambucil-d8 (CB-1348-d8; WR-139013-d8) | Chlorambucil-d8 is the deuterium labelled form of Chlorambucil. | |
|
V80525 | Chlorambucil-d8-1 (CB-1348-d8-1; WR-139013-d8-1) | Chlorambucil-d8-1 is the deuterium labelled form of Chlorambucil. | |
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V55757 | Colibactin 742 | 2916559-62-9 | Colibactin 742 is a stable derivative of colicin that causes G2/M phase arrest, DNA interstrand cross-linking, and the Fanconi Anemia DNA repair pathway to be activated. |
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V56575 | Cyclophosphamide-d4 (cyclophosphamide d4) | 173547-45-0 | Cyclophosphamide-d4 is the deuterated form of Cyclophosphamide. |
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V78956 | Cyclophosphamide-d8 hydrate (cyclophosphamide hydrate d8 (hydrate)) | Cyclophosphamide-d8 (hydrate) is the deuterated form of Cyclophosphamide hydrate. | |
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V55759 | DNA crosslinker 1 dihydrochloride | 2761734-27-2 | DNA crosslinker 1 (dihydrochloride) is a novel DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.1 °C. |
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V52167 | DNA crosslinker 2 dihydrochloride | 2761734-25-0 | DNA crosslinker 2 (dihydrochloride) is a selective DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.2 °C. |
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V55760 | DNA crosslinker 3 dihydrochloride | 2761734-21-6 | DNA crosslinker 3 (dihydrochloride) (compound 1) is a DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.4 °C. |
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V52166 | DNA crosslinker 4 dihydrochloride | 2761734-23-8 | DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. |
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V21870 | GSK3117391 | 1018673-42-1 | HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor. |
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V56577 | Ifosfamide-d4 (Ifosfamide d4) | 1189701-13-0 | Ifosfamide-d4 is the deuterium labelled form of Ifosfamide. |
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