DNA alkylator

DNA alkylator

A molecule known as a DNA alkylator or crosslinker can alkylate DNA or form a crosslink with DNA. The effects of a DNA alkylator or crosslinker can be mutagenic, therapeutic, or other. Transferring an alkyl group from one molecule to another is known as alkylation. The alkyl group can be transferred as a free radical, a carbanion, a carbene, or an alkyl carbocation.Alkyl groups are probably the most frequent group found in organic molecules, so alkylating agents are frequently used in chemistry. When there isn't a readily accessible biological precursor, selective alkylation—adding pieces of the chain with the desired functional groups—is used. Methylation is the name for alkylation with one carbon. Chemotherapy in medicine employs DNA alkylation to harm cancer cells' DNA. Alkylating antineoplastic agents are a class of medications that cause alkylation.When different exogenous or endogenous agents react with two different positions in the DNA, crosslinking of the DNA results. This can happen within the same strand of the DNA (intrastrand crosslink) or between the DNA strands (interstrand crosslink). Protein and DNA can crosslink with one another. Crosslinks prevent DNA from replicating, which stops replication and results in cell death if the crosslink is not repaired. The RAD51 family is involved in maintenance.

DNA alkylator related products

Structure Cat No. Product Name CAS No. Product Description
V77442 (Rac)-Melphalan-d8
V52948 2-Iodoacetamide (iodoacetamide; Iodoacetamide) 144-48-9 2-Iodoacetamide (Iodoacetamide) is a commonly used alkylating agent that is used to alkylate cysteine in the process of preparing proteomics samples.
V56576 2-Iodoacetamide-d4 (Iodoacetamide-d4) 1219802-64-8 2-Iodoacetamide-d4 is the deuterated form of 2-Iodoacetamide.
V2028 Altretamine (ENT-50852) 645-05-6 Altretamine (also known as Hexamethylmelamine, NSC13875, ENT50852, WR-95704) is an alkylating anticancer drug which also acts as a chemosterilant for male houseflies and other insects.
V55758 Anticancer agent 11 2332936-95-3 Anticancer agent 11 is a broad-spectrum anticancer drug that promotes DNA cross-linking and suppresses angiogenesis.
V51722 ASTA-6496 (4-Hydroperoxy cyclophosphamide) 39800-16-3 4-Hydroperoxy cyclophosphamide, active metabolite form of the proagent Cyclophosphamide.
V78368 Bendamustine-d4 (SDX-105-d4 (free base))
V5078 Busulfan (Myleran, Busulfex) 55-98-1 Busulfan (Myleran; Busulfex IV) is a potent DNA alkylating agent with selective immunosuppressive effect on bone marrow.
V50952 Busulfan-D8 116653-28-2 Busulfan-d8 is a deuterated form of Busulfan.
V80524 Chlorambucil-d8 (CB-1348-d8; WR-139013-d8)
V80525 Chlorambucil-d8-1 (CB-1348-d8-1; WR-139013-d8-1)
V55757 Colibactin 742 2916559-62-9 Colibactin 742 is a stable derivative of colicin that causes G2/M phase arrest, DNA interstrand cross-linking, and the Fanconi Anemia DNA repair pathway to be activated.
V56575 Cyclophosphamide-d4 (cyclophosphamide d4) 173547-45-0 Cyclophosphamide-d4 is the deuterated form of Cyclophosphamide.
V78956 Cyclophosphamide-d8 hydrate (cyclophosphamide hydrate d8 (hydrate))
V55759 DNA crosslinker 1 dihydrochloride 2761734-27-2 DNA crosslinker 1 (dihydrochloride) is a novel DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.1 °C.
V52167 DNA crosslinker 2 dihydrochloride 2761734-25-0 DNA crosslinker 2 (dihydrochloride) is a selective DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.2 °C.
V55760 DNA crosslinker 3 dihydrochloride 2761734-21-6 DNA crosslinker 3 (dihydrochloride) (compound 1) is a DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.4 °C.
V52166 DNA crosslinker 4 dihydrochloride 2761734-23-8 DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder.
V21870 GSK3117391 1018673-42-1 GSK3117391, formerly known as GSK3117391A, is a potent HDAC inhibitor for treating chronic inflammatory disorders.
V56577 Ifosfamide-d4 (Ifosfamide d4) 1189701-13-0 Ifosfamide-d4 is the deuterated form of Ifosfamide.
Contact Us