Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.The GR regulates the genes that control development, metabolism, and immune response and is expressed in almost all body cells. The regulation of gene transcription is the main mechanism by which the glucocorticoid receptor functions when it binds to glucocorticoids.The cell's cytosol is home to the unbound receptor. The receptor-glucocorticoid complex can proceed in one of two ways after the glucocorticoid and receptor are bound together. By preventing other transcription factors from moving from the cytosol into the nucleus, the activated GR complex controls the expression of anti-inflammatory proteins in the nucleus or suppresses the expression of pro-inflammatory proteins in the cytosol. Dexamethasone is an agonist, while cyproterone acetate and RU486 are GR antagonists. Progesterone and DHEA also negatively affect the GR.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1716 | Beclomethasone dipropionate (Beclomethasone) | 5534-09-8 | Beclomethasone dipropionate (also called BDP;Clenil; Qvar; Beconase; alanase; Vancenase) is a topical anti-inflammatory corticosteroid approved for use in treatment of asthma and rhinitis. |
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V18641 | Corticosterone | 50-22-6 | Corticosterone is an adrenocortical steroid and also an endogenous steroid hormone involved in immune responses, stress responses and energy homeostasis. |
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V19657 | Dexamethasone palmitate (DXP) | 14899-36-6 | Dexamethasone palmitate, the palmitate salt and a prodrug ofDexamethasone withanti-inflammatory and immunosuppressant activities, is a liposteroid for treatment of hemophagocytic lymphohistiocytosis. |
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V1720 | Flumethasone (Flumetasone) | 2135-17-3 | Flumethasone (NSC-54702;RS-2177; U-10974;RS2177; BRN-5645455;NSC54702; Anaprime; Aniprime; Fluvet; Methagon; Cortexilar; Flucort; Flucorticin;Locacorten),a topically used corticosteroid, is a potent glucocorticoid receptor agonist with potential anti-inflammatory activity. |
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V1717 | Fluocinolone Acetonide | 67-73-2 | Fluocinolone Acetonide (Flucort-N;Flucinar, Fluonid, Synandone, Jellin, Sinalar) is a topical and synthetic glucocorticoid withwith anti-inflammatory and immunomodulating properties. |
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V51050 | Glucocorticoid receptor modulator 1 | 2868357-11-1 | Glucocorticoid receptor modulator 1 is a potent epidermal agent for NF-κB and AP-1, with IC50s of 9 nM and 130 nM, respectively. |
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V1718 | Prednisolone Acetate (Omnipred) | 52-21-1 | Prednisolone Acetate (also called Omnipred; Prednisolone 21-acetate) is a synthetic corticosteroid drug approved for use as an immunosuppressant,anti-inflammatory, and anti-allergicagent. |
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V5626 | Prednisolone Phosphate Sodium | 125-02-0 | Prednisolone sodium phosphate is a water soluble form of prednisolone and a glucocorticoid with anti-inflammatory and immunomodulating properties. |
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V1719 | Triamcinolone | 124-94-7 | Triamcinolone (BRN2341955;Adcortyl; BRN-2341955; Aristocort),a long-acting synthetic corticosteroid, is an approved glucocorticoid medication with anti-inflammatory activities. |
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