Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.The GR regulates the genes that control development, metabolism, and immune response and is expressed in almost all body cells. The regulation of gene transcription is the main mechanism by which the glucocorticoid receptor functions when it binds to glucocorticoids.The cell's cytosol is home to the unbound receptor. The receptor-glucocorticoid complex can proceed in one of two ways after the glucocorticoid and receptor are bound together. By preventing other transcription factors from moving from the cytosol into the nucleus, the activated GR complex controls the expression of anti-inflammatory proteins in the nucleus or suppresses the expression of pro-inflammatory proteins in the cytosol. Dexamethasone is an agonist, while cyproterone acetate and RU486 are GR antagonists. Progesterone and DHEA also negatively affect the GR.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V88954 | (R)-GSK866 | 1094607-80-3 | (R)-GSK866 is the R-enantiomer of GSK866. |
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V86855 | 2-O-trans-p-Coumaroylalphitolic acid | 67911-63-1 | 2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpenoid extracted from the jujube plant. |
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V86852 | 21-Desacetyldeflazacort-d5 | 21-Desacetyldeflazacort-d5 is the deuterated form of 21-Desacetyldeflazacort. | |
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V86859 | GA32 | 1386811-71-7 | GA32 (compound 58r) is a potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. |
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V51050 | Glucocorticoid receptor modulator 1 | 2868357-11-1 | Glucocorticoid receptor modulator 1 is a potent epidermal agent for NF-κB and AP-1, with IC50s of 9 nM and 130 nM, respectively. |
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V86856 | Glucocorticoid receptor modulator 3 | 2688785-13-7 | Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC50=0.6 nM). |
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V86125 | GSK866 | 1991970-93-4 | |
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V86854 | Hydrocortisone hemisuccinate hydrate | 83784-20-7 | Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID). |
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V97417 | IONIS-GCCRRx | 1431900-72-9 | IONIS-GCCRRx (ISIS 426115) is a glucocorticoid receptor antagonist, a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO). |
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V97431 | IONIS-GCCRRx sodium | IONIS-GCCRRx (ISIS 426115) sodium is a glucocorticoid receptor antagonist and 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO). | |
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V86853 | LY2623091 | 1162264-07-4 | LY2623091 is a mineralocorticoid receptor antagonist that can be used to inhibit refractory hypertension. |
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V86860 | Toripristone | 91935-26-1 | Toripristone (RU-40555) is a cortisol receptor inhibitor. |
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V1716 | Beclomethasone dipropionate (Beclomethasone) | 5534-09-8 | Beclomethasone dipropionate (also called BDP;Clenil; Qvar; Beconase; alanase; Vancenase) is a topical anti-inflammatory corticosteroid approved for use in treatment of asthma and rhinitis. |
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V19657 | Dexamethasone palmitate (DXP) | 14899-36-6 | Dexamethasone palmitate, the palmitate salt and a prodrug ofDexamethasone withanti-inflammatory and immunosuppressant activities, is a liposteroid for treatment of hemophagocytic lymphohistiocytosis. |
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V1719 | Triamcinolone | 124-94-7 | Triamcinolone (BRN2341955;Adcortyl; BRN-2341955; Aristocort),a long-acting synthetic corticosteroid, is an approved glucocorticoid medication with anti-inflammatory activities. |
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V1720 | Flumethasone (Flumetasone) | 2135-17-3 | Flumethasone (NSC-54702;RS-2177; U-10974;RS2177; BRN-5645455;NSC54702; Anaprime; Aniprime; Fluvet; Methagon; Cortexilar; Flucort; Flucorticin;Locacorten),a topically used corticosteroid, is a potent glucocorticoid receptor agonist with potential anti-inflammatory activity. |
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V5626 | Prednisolone Phosphate Sodium | 125-02-0 | Prednisolone sodium phosphate is a water soluble form of prednisolone and a glucocorticoid with anti-inflammatory and immunomodulating properties. |
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V18641 | Corticosterone | 50-22-6 | Corticosterone is an adrenocortical steroid and also an endogenous steroid hormone involved in immune responses, stress responses and energy homeostasis. |
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V1717 | Fluocinolone Acetonide | 67-73-2 | Fluocinolone Acetonide (Flucort-N;Flucinar, Fluonid, Synandone, Jellin, Sinalar) is a topical and synthetic glucocorticoid withwith anti-inflammatory and immunomodulating properties. |
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V1718 | Prednisolone Acetate (Omnipred) | 52-21-1 | Prednisolone Acetate (also called Omnipred; Prednisolone 21-acetate) is a synthetic corticosteroid drug approved for use as an immunosuppressant,anti-inflammatory, and anti-allergicagent. |
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