Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4719 | BI-6C9 | 791835-21-7 | BI-6C9 is a novel and potent inhibitor of BH3 interacting domain (Bid) with Kd of 20 µM, it acts by preventing mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protecting the cells from cell death. |
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V73521 | CP-346086 | 186390-48-7 | CP-346086 is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP. |
|
V73522 | CP-346086 dihydrate | 1262769-98-1 | CP-346086 dihydrate is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP. |
|
V72006 | DS44960156 | 2361327-08-2 | DS44960156 is a selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with IC50s of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively. |
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V73208 | DX3-234 | 2941323-59-5 | DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. |
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V73213 | DX3-235 | 2749555-39-1 | DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. |
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V29295 | ER-000444793 | 792957-74-5 | ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. |
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V3679 | FCCP | 370-86-5 | FCCP (full name: Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) is an ionophore and often referred to as a mitochondrial uncoupling agent. |
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V73207 | Fenpyroximate | 111812-58-9 | Fenpyroximate is an acaricide and insecticide used on crops and ornamental plants. |
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V73200 | Fumarate hydratase-IN-2 sodium salt | 2070009-45-7 | Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-penetrating/penetrable, competitive inhibitor of fumarate hydratase (Ki=4.5 μM) with nutrient-dependent cell toxicity/cytotoxicity. |
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V73218 | Glutamate dehydrogenase (NAD(P)) (GLDH) | 9029-12-3 | Glutamate dehydrogenase NAD(P) (GLDH) is found in liver cells, kidney tissue, brain, muscle and intestinal cells. |
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V2382 | GW604714X | 853953-65-8 | GW604714X is a potent inhibitor of mitochondrial respiration. |
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V2181 | HQNO | 341-88-8 | HQNO, secreted byP. |
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V3751 | IACS-010759 HCl | 1807523-99-4 | IACS-10759 HCl (IACS10759; IACS-010759) was identified as a potent and orally bioavailable inhibitor of complex I of oxidative phosphorylation (OXPHOS) with anticancer activity. |
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V3750 | IACS-10759 | 1570496-34-2 | IACS-10759 (IACS10759) is a potent and orally bioavailable inhibitor of OXPHOS (complex I of oxidative phosphorylation) with antitumor effects. |
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V2310 | Idebenone (CV-2619) | 58186-27-9 | Idebenone (also known as CV-2619)is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant. |
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V73204 | IM176OUT05 | 1643659-96-4 | IM176OUT05 is a highly soluble biguanide. |
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V5065 | KL-1333 | 1800405-30-4 | KL1333,a novel NAD+modulator, is a potent, orally bioavailable and small organic molecule with the potential to treatMitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). |
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V2257 | LDC195943 (IMT1) | 2304621-31-4 | LDC195943 (also known as IMT1) is a novel, potent and highly specific inhibitor of POLRMT (human mitochondrial RNA polymerase) with anticancer activity. |
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V73214 | Leramistat (HMC-C-01-A; MBS2320) | 1642602-54-7 | Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor involved in the regulation of cellular metabolism and immunometabolism. |
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