Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V9679 | MSDC-0602 | 1133819-87-0 | MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator). | |
V87604 | 8-OAc | 2550395-87-2 | 8-OAc is a potent and selective inhibitor of mitochondrial electron transport chain (ETC) complex I. | |
V4719 | BI-6C9 | 791835-21-7 | BI-6C9 is a novel and potent inhibitor of BH3 interacting domain (Bid) with Kd of 20 µM, it acts by preventing mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protecting the cells from cell death. | |
V73521 | CP-346086 | 186390-48-7 | CP-346086 is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP. | |
V73522 | CP-346086 dihydrate | 1262769-98-1 | CP-346086 dihydrate is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP. | |
V88836 | DBI-2 | 2939087-00-8 | DBI-2 is an AMPK activator that targets mitochondrial complex I. | |
V72006 | DS44960156 | 2361327-08-2 | DS44960156 is a selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with IC50s of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively. | |
V73208 | DX3-234 | 2941323-59-5 | DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. | |
V73213 | DX3-235 | 2749555-39-1 | DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. | |
V87599 | Elamipretide triacetate | 1849610-71-4 | Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is the free triacetate form of Elamipretide. | |
V29295 | ER-000444793 | 792957-74-5 | ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. | |
V3679 | FCCP | 370-86-5 | FCCP (full name: Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) is an ionophore and often referred to as a mitochondrial uncoupling agent. | |
V73207 | Fenpyroximate | 111812-58-9 | Fenpyroximate is an acaricide and insecticide used on crops and ornamental plants. | |
V73200 | Fumarate hydratase-IN-2 sodium salt | 2070009-45-7 | Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-penetrating/penetrable, competitive inhibitor of fumarate hydratase (Ki=4.5 μM) with nutrient-dependent cell toxicity/cytotoxicity. | |
V84430 | Fusaramin | 2374906-71-3 | ||
V73218 | Glutamate dehydrogenase (NAD(P)) (GLDH) | 9029-12-3 | Glutamate dehydrogenase NAD(P) (GLDH) is found in liver cells, kidney tissue, brain, muscle and intestinal cells. | |
V87600 | Glutathione arsenoxide TFA | Glutathione arsenoxide (GSAO) TFA is a potential anticancer active molecule and tumor metabolism inhibitor. | ||
V2382 | GW604714X | 853953-65-8 | GW604714X is a potent inhibitor of mitochondrial respiration. | |
V2181 | HQNO | 341-88-8 | HQNO, secreted byP. | |
V3750 | IACS-10759 | 1570496-34-2 | IACS-10759 (IACS10759) is a potent and orally bioavailable inhibitor of OXPHOS (complex I of oxidative phosphorylation) with antitumor effects. |