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Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.

Mitochondrial Metabolism related products

Structure Cat No. Product Name CAS No. Product Description
5-[[4-[2-(3-甲氧基苯基)-2-氧代乙氧基]苯基]甲基]-2,4-噻唑烷二酮 V9679 MSDC-0602 1133819-87-0 MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).
8-OAc V87604 8-OAc 2550395-87-2 8-OAc is a potent and selective inhibitor of mitochondrial electron transport chain (ETC) complex I.
BI-6C9 V4719 BI-6C9 791835-21-7 BI-6C9 is a novel and potent inhibitor of BH3 interacting domain (Bid) with Kd of 20 µM, it acts by preventing mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protecting the cells from cell death.
CP-346086 V73521 CP-346086 186390-48-7 CP-346086 is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP.
CP-346086 dihydrate V73522 CP-346086 dihydrate 1262769-98-1 CP-346086 dihydrate is a potent and orally bioactive microsomal triglyceride transfer protein (MTP) inhibitor (antagonist) with IC50 of 2.0 nM for human and rodent MTP.
DBI-2 V88836 DBI-2 2939087-00-8 DBI-2 is an AMPK activator that targets mitochondrial complex I.
DS44960156 V72006 DS44960156 2361327-08-2 DS44960156 is a selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with IC50s of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively.
DX3-234 V73208 DX3-234 2941323-59-5 DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor.
DX3-235 V73213 DX3-235 2749555-39-1 DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor.
Elamipretide triacetate V87599 Elamipretide triacetate 1849610-71-4 Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is the free triacetate form of Elamipretide.
ER-000444793 V29295 ER-000444793 792957-74-5 ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening.
FCCP V3679 FCCP 370-86-5 FCCP (full name: Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) is an ionophore and often referred to as a mitochondrial uncoupling agent.
Fenpyroximate V73207 Fenpyroximate 111812-58-9 Fenpyroximate is an acaricide and insecticide used on crops and ornamental plants.
Fumarate hydratase-IN-2 sodium salt V73200 Fumarate hydratase-IN-2 sodium salt 2070009-45-7 Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-penetrating/penetrable, competitive inhibitor of fumarate hydratase (Ki=4.5 μM) with nutrient-dependent cell toxicity/cytotoxicity.
Fusaramin V84430 Fusaramin 2374906-71-3
Glutamate dehydrogenase (NAD(P)) (GLDH) V73218 Glutamate dehydrogenase (NAD(P)) (GLDH) 9029-12-3 Glutamate dehydrogenase NAD(P) (GLDH) is found in liver cells, kidney tissue, brain, muscle and intestinal cells.
Glutathione arsenoxide TFA V87600 Glutathione arsenoxide TFA Glutathione arsenoxide (GSAO) TFA is a potential anticancer active molecule and tumor metabolism inhibitor.
GW604714X V2382 GW604714X 853953-65-8 GW604714X is a potent inhibitor of mitochondrial respiration.
HQNO V2181 HQNO 341-88-8 HQNO, secreted byP.
IACS-10759 V3750 IACS-10759 1570496-34-2 IACS-10759 (IACS10759) is a potent and orally bioavailable inhibitor of OXPHOS (complex I of oxidative phosphorylation) with antitumor effects.
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