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5 alpha Reductase

5 alpha Reductase

A membrane-bound protein called steroid 5-reductase (5AR) converts steroids like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstanedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.

Sexual development disorders result from the inactivating mutations in 5R2. Prostate cancer (PC) and benign prostate hyperplasia (BPH) are both treated by controlling the 5AR, and 5AR inhibitors are frequently used to treat androgen-dependent benign or malignant prostatic diseases.

5 alpha Reductase related products

Structure Cat No. Product Name CAS No. Product Description
12-O-Methylcarnosic acid (12-Methoxycarnosic acid) V73877 12-O-Methylcarnosic acid (12-Methoxycarnosic acid) 62201-71-2 12-O-Methylcarnosic acid (12-Methoxycarnosic acid) is a diterpene cinnamic acid extracted from the acetone extract of Salvia miltiorrhiza.
17a-雌二醇 V30062 Alpha-Estradiol 57-91-0 Alpha-Estradiol,an endogenous estrogen receptor ligand, is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
Pedunculagin V73878 Pedunculagin 113866-64-1 Pedunculagin is a potent 5α-reductase type 1 inhibitor.
爱普列特 V3963 EPRISTERIDE 119169-78-7 Epristeride (ONO-9302; SKF105657; sold under the brand names Aipuliete and Chuanliu) is an orally available medication used for the treatment of enlarged prostate in China.
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