A membrane-bound protein called steroid 5-reductase (5AR) converts steroids like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstanedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.
Sexual development disorders result from the inactivating mutations in 5R2. Prostate cancer (PC) and benign prostate hyperplasia (BPH) are both treated by controlling the 5AR, and 5AR inhibitors are frequently used to treat androgen-dependent benign or malignant prostatic diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V97486 | (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one | 420781-85-7 | (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one exhibits 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. |
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V73877 | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid) | 62201-71-2 | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid) is a diterpene cinnamic acid extracted from the acetone extract of Salvia miltiorrhiza. |
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V30062 | Alpha-Estradiol | 57-91-0 | Alpha-Estradiol,an endogenous estrogen receptor ligand, is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia. |
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V127219 | 5α-reductase, Rat(Sprague-Dawley) Liver | 5α-reductase, Rat (Sprague-Dawley) Liver, is an enzyme involved in steroid metabolism and is also part of the androgen metabolism pathway. | |
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V127220 | 5α-reductase, Rat(Sprague-Dawley) Testis | 5α-reductase, Rat(Sprague-Dawley) Testis, is an enzyme responsible for converting testosterone into 5α-dihydrotestosterone (DHT), a potent androgen involved in male sexual differentiation. | |
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V138527 | Kushenol Q | 254886-70-9 | Matrine Q (compound 2) can inhibit testosterone 5α-reductase and 5α-dihydrotestosterone receptor. |
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V73878 | Pedunculagin | 113866-64-1 | Pedunculagin is a potent 5α-reductase type 1 inhibitor. |
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V3963 | EPRISTERIDE | 119169-78-7 | Epristeride (ONO-9302; SKF105657; sold under the brand names Aipuliete and Chuanliu) is an orally available medication used for the treatment of enlarged prostate in China. |
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