The farnesoid X receptor (FXR) is a nuclear receptor superfamily member and ligand-activated transcription factor. By binding to DNA as a monomer or a heterodimer with the common NR partner, retinoid x receptor (RXR), to FXR response elements, FXR controls the expression of numerous genes. The FXR and FXR genes are the two recognized FXR genes.
FXR is primarily expressed in the liver and small intestine, where it is critical for the metabolism of bile acids, lipids, and glucose. FXR regulates bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, as well as playing a significant role in intestinal bacterial growth and liver regeneration through its specific target genes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V85288 | (E)-GW 4064 | 1089660-72-9 | |
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V108742 | 2-Oxokolavenol | 130395-82-3 | 2-O-clavulanic acid is a selective farnesoid X receptor (FXR) agonist with an EC50 of approximately 3.7 μM. |
|
V1844 | Obeticholic Acid (6-ECDCA; INT-747) | 459789-99-2 | Obeticholic Acid (INT747; 6-ECDCA; 6-Ethylchenodeoxycholic acid; trade name Ocaliva), a novel derivative of cholic acid, is a potent,orally bioactive and selectiveagonist of farnesoid X receptor (FXR) with EC50 of 99 nM, and has anticholeretic and anti-inflammatory activities. |
|
V74026 | Alismanol M | 2408810-59-1 | Alismanol M is an agonist of farnesoid X receptor (FXR) with EC50 of 50.25 μM. |
|
V94855 | BAR-2227 | 2409154-23-8 | BAR-2227 (compound 3a) is a FXR agonist and LIFR inhibitor. |
|
V107203 | Chenodeoxycholic acid 24-acyl-β-D-glucuronide | 208038-27-1 | Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of chenodeoxycholic acid. |
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V107201 | Chenodeoxycholic acid 3-glucuronide | 58814-71-4 | Chenodeoxycholic acid 3-glucuronide is a metabolite of chenodeoxycholic acid, which can activate key nuclear receptors (FXR) with an EC50 of 8 μM and an EC50 of 11 μM for FXR activation in HEK293T cells. |
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V18332 | Cilofexor | 1418274-28-8 | Cilofexor, formerly known as GS-9674, is a farnesoid X receptor (FXR) agonist. |
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V94323 | Cilofexor tromethamine | 2253764-93-9 | Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal oxidized farnesene receptor agonist with activity in improving markers of cholestasis and liver injury. |
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V109415 | Deoxycholic acid 3-O-β-D-glucuronide disodium | 59274-67-8 | Deoxycholic acid 3-O-β-D-glucuronide disodium salt is a bile acid receptor (FXR) agonist. |
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V118363 | dual FXR/PPARδ agonist-2 | Dual FXR/PPARδ agonist-2 is a dual FXR/PPARδ agonist produced by hybridizing FXR agonist GW-4064 and PPARδ agonist GW-0742. | |
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V74025 | Fargesone A | 116424-69-2 | Fargesone A is a potent and specific FXR agonist. |
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V104307 | FXR agonist 10 | FXR agonist 10 (Compound 27) is an agonist of FXR with an EC50 of 14.26 μM. | |
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V104308 | FXR agonist 11 | 2768502-17-4 | FXR agonist 11 (Compound 14) is a FXR agonist with an EC50 of 1.2 μM and a maximal effect of 73.7%. |
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V115591 | FXR agonist 13 | FXR agonist 13 is a highly selective, orally effective, and potent FXR agonist (EC50 = 0.097 μM) with good hepatic microsomal metabolic stability. | |
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V110803 | FXR agonist 14 | 3062988-46-6 | FXR agonist 14 (compound V15) is a partially selective, orally effective FXR agonist with an EC50 value of 0.67 nM. |
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V110955 | FXR agonist 15 | 2991276-14-1 | FXR agonist 15 is a selective, orally effective farnesoid X receptor (FXR) agonist with an EC50 value of 0.76 μM. |
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V87447 | FXR agonist 3 | FXR agonist 3 is an anti-NASH agent that acts by activating FXR. | |
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V87448 | FXR agonist 4 | 3025841-47-5 | FXR agonist 4 (compound 10a) is a farnesoid X receptor (FXR) agonist with an EC50 value of 1.05 μM. |
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V87449 | FXR agonist 7 | FXR agonist 7 (compound 33) is a potent agonist of FXR with an EC50 of 0.1 nM. |
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