FXR

FXR

The farnesoid X receptor (FXR) is a nuclear receptor superfamily member and ligand-activated transcription factor. By binding to DNA as a monomer or a heterodimer with the common NR partner, retinoid x receptor (RXR), to FXR response elements, FXR controls the expression of numerous genes. The FXR and FXR genes are the two recognized FXR genes.

FXR is primarily expressed in the liver and small intestine, where it is critical for the metabolism of bile acids, lipids, and glucose. FXR regulates bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, as well as playing a significant role in intestinal bacterial growth and liver regeneration through its specific target genes.

FXR related products

Structure Cat No. Product Name CAS No. Product Description
V74026 Alismanol M 2408810-59-1
V18332 Cilofexor 1418274-28-8 Cilofexor, formerly known as GS-9674, is a farnesoid X receptor (FXR) agonist.
V74025 Fargesone A 116424-69-2
V74032 FXR antagonist 1 2295804-68-9
V74028 FXR antagonist 2 1660153-21-8
V78496 FXRagonist 3
V79540 FXRagonist 4
V74031 FXRagonist 5 2414008-05-0
V29731 Gly-β-MCA 66225-78-3 Gly-β-MCA is a bile acid acting as an oral and potent farnesoid X receptor (FXR) inhibitor with the potential to be usedfor the treatment of metabolic disorders.
V40096 Glyco-Obeticholic acid 863239-60-5 Glyco-Obeticholic acid is an active metabolite of Obeticholic acid formed by a phase II metabolic reaction by conjugating with amino acid glycine.
V79622 Glyco-obeticholic acid-d5 (obeticholic acid impurity 8-d5)
V74024 HEC96719 2181834-03-5
V74030 Hedragonic acid 466-02-4
V74027 Nelumol A 77836-86-3
V1844 Obeticholic Acid (6-ECDCA; INT-747) 459789-99-2 Obeticholic Acid (INT747; 6-ECDCA; 6-Ethylchenodeoxycholic acid; trade name Ocaliva), a novel derivative of cholic acid, is a potent,orally bioactive and selectiveagonist of farnesoid X receptor (FXR) with EC50 of 99 nM, and has anticholeretic and anti-inflammatory activities.
V40095 Tauro-Obeticholic acid 863239-61-6 Tauro-Obeticholic acid is an active metabolite of Obeticholic acid(Ocaliva; 6-ECDCA;INT747; 6-Ethylchenodeoxycholic acid) formed by conjugating with taurine, or 2-aminoethanesulfonic acid.
V78711 Tauro-β-muricholic acid-d4 sodium
V78572 XJ02862-S2
V81777 ZLY28
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