Carbon dioxide is reversibly hydrated by a zinc-containing enzyme called carbonic anhydrase (CA): CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as α--CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian α--CA isoforms.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2629 | Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide) | 98-10-2 | Benzenesulfonamide (Phenyl sulfonamide, Benzene sulfonamide), the amide of benzenesulfonic acid, ia an inhibitor of carbonic anhydrases (CAI). |
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V2261 | EMAC10101d | 2561476-24-0 | EMAC10101dbearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring,is a novel, potent and selective inhibitor of Carbonic Anhydrase Isoform toward hCA II |
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V5266 | Indisulam (E 7070) | 165668-41-7 | Indisulam (formerly E-7070; ER-35744; D-04522), a synthetic aryl sulfonamide, is a potent CAI-carbonic anhydrase inhibitor withpotential anticancer activity. |
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V0895 | U-104 | 178606-66-1 | U-104 (MST-104; U104; SLC-0111; NSC-213841) is a novel and potent inhibitor of transmembrane carbonic anhydrase (CA) with potential antineoplastic activity. |
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V0905 | Paeonol | 552-41-0 | Paeonol (also known as NSC-401442; NSC401442;Peonol), a naturally occurring phenolic compound isolated from Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum which are used in traditional Chinese herbs/medicines. |
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V0899 | Dichlorphenamide | 120-97-8 | Dichlorphenamide (Daranide;Diclofenamide; Dichlofenamide)is a sulfonamide analog acting as a CAI/carbonic anhydrase inhibitor, it belongs to the meta-Disulfamoylbenzene class. |
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V0903 | Tranylcypromine (2-PCPA) HCl | 1986-47-6 | Tranylcypromine HCl (also known as SKF385 HCl;2-PCPA) is discontinued. |
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V0896 | Tioxolone | 4991-65-5 | Tioxolone (Thioxolone) is a potent inhibitor of metalloenzyme carbonic anhydrase I with a variety of activities such as cytostatic, antipsoriatic, anti-acne, antibacterial and anti-mycotic properties. |
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V0898 | Brinzolamide | 138890-62-7 | Brinzolamide (AL-4862; AL4862;Azopt, Alcon Laboratories, Befardin, AL4862)is a highly potent and selective CAI (carbonic anhydrase II inhibitor) with anti-hypertensive activity. |
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V0894 | Topiramate | 97240-79-4 | Topiramate (MCN-4853; RWJ-17021;HSDB-7531; Tipiramato; Topax)isan approved anticonvulsant (antiepilepsy) drug usedto treat certain types of seizures. |
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V2649 | Safinamide | 133865-89-1 | Safinamide (formerly known as EMD-1195686; FCE-26743;EMD1195686; FCE26743; trade name:Xadago) is an FDA approved anti-PD (Parkinsons disease) drug. |
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V0901 | Safinamide Mesylate | 202825-46-5 | Safinamide Mesylate (formerly PNU-151774E, FCE-28073; NW-1015; EMD-1195686;Xadago), the mesylate salt of Safinamide, is a selective and reversible inhibitor of MAO-B with anti-PD (Parkinsons diseas) effects. |
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V0902 | Rasagiline Mesylate | 161735-79-1 | Rasagiline mesylate (TVP-101;TV-1030,TVP-1022;Agn-1135;Azilect)is a potent, selective and irreversible MAO-B (monoamine oxidase B) inhibitor with the potential for the treatment of idiopathic PD/Parkinson''''s disease. |
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V0906 | Sennoside A | 81-27-6 | Sennoside A (formerly also known as NSC112929;NSC-112929), used as a laxative and an anti-constipation agent,is a naturally occurring dianthrone glycoside compound isolated from Rhei Rhizoma and senna leaf. |
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V0893 | Dorzolamide HCl | 130693-82-2 | Dorzolamide HCl (also known as MK-507; L-671152 HCl; L671152; MK507; trade name Trusopt), an anti-glaucoma agent and CAI (carbonic anhydrase inhibitors),is a water-soluble and potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively. |
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V2650 | Tranylcypromine hemisulfate | 13492-01-8 | Tranylcypromine hemisulfate, also known as 2-PCPA, is a nonselective and irreversible monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. |
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V0897 | Methocarbamol | 532-03-6 | Methocarbamol (Robaxin; AHR85; Lumirelax; AHR-85; Metocarbamolo),a carbamate analog of guaifenesin, is a potentcarbonic anhydrase inhibitor (CAI) with sedative and musculoskeletal relaxant properties. |
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V0900 | Methazolamide | 554-57-4 | Methazolamide (Neptazaneat; Naptazane;CL-8490;CL8490)is a highly potent and selective inhibitor of carbonic anhydrase (CAI) with important biological activity. |
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V0904 | Moclobemide (Ro 111163) | 71320-77-9 | Moclobemide(Ro-111163; Ro11-1163; Ro 11-1163; Amira; Aurorix; Clobemix; Depnil; Manerix) is a novel, potent,reversible monoamine oxidaseMAO-A (5-HT) inhibitor with anti-depressant and anti-anxiety effects. |
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