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HMGCR

HMGCR

HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate.Eukaryotes and prokaryotes both contain HMGCR. Two classes of HMG-CoA reductase have been identified through phylogenetic analysis: Class I enzymes found in some eukaryotes and archaea and Class II enzymes found in some eubacteria and other archaea.

The enzyme HMGCR is known to catalyze an early reaction specific to isoprenoid biosynthesis in both eukaryotes and archaebacteria. Drugs used to lower serum cholesterol levels frequently target the HMG-CoA reductase reaction because it is rate-limiting for the biosynthesis of cholesterol in humans.

HMGCR related products

Structure Cat No. Product Name CAS No. Product Description
((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) V121120 ((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) 1422515-55-6 ((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) is an impurity in the bulk formulation of rosuvastatin, an HMG-CoA reductase inhibitor.
(Z)-Ganoderenic acid K V105922 (Z)-Ganoderenic acid K 1910062-54-2 (Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum.
24,25-Epoxycholesterol V107128 24,25-Epoxycholesterol 72542-49-5 24,25-Epoxycholesterol is an oxysterol agonist of liver X receptors and inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) in hepatocytes.
Adenosine-5'-O-diphosphoribose phosphate sodium V128314 Adenosine-5'-O-diphosphoribose phosphate sodium Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analogue of NADPH.
Atorvastatin (lysine) V129601 Atorvastatin (lysine) 609843-23-4 Atorvastatin (lysine) is an HMG-CoA reductase inhibitor.
Atorvastatin strontium V93945 Atorvastatin strontium 1072903-92-4 Strontium atorvastatin is a cholesterol-lowering drug with activity in improving cardiovascular disease-related events.
Bemfivastatin hemicalcium (PPD 10558 hemicalcium) V74034 Bemfivastatin hemicalcium (PPD 10558 hemicalcium) 805241-64-9 Bemfivastatin (PPD 10558) hemicalcium is an orally bioactive lipid-lowering agent and HMG-CoA reductase inhibitor.
BMS-180431 sodium V109024 BMS-180431 sodium 131177-45-2 BMS-180431 sodium is an HMG-CoA reductase inhibitor (IC50: 43 nM).
Colestolone V112700 Colestolone 50673-97-7 Cholestone is a 15-ketosterol compound and an HMG-CoA reductase inhibitor.
Dihydrocompactin V133800 Dihydrocompactin 78366-44-6 Dihydrocompactin is an antifungal metabolite that inhibits 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in Penicillium citrinum.
Dihydromevinolin V133813 Dihydromevinolin 77517-29-4 Dihydromevinolin is a potent cholesterol-lowering metabolite produced by Aspergillus terreus.
Fluvastatin lactone V103146 Fluvastatin lactone 94061-83-3 Fluvastatin lactone, the lactone form of fluvastatin, induces myotoxicity in human skeletal muscle cells.
Ganoderenic acid K V74033 Ganoderenic acid K 942950-94-9 Ganoderenic acid K is a naturally occurring compound extracted from the fruiting bodies of Ganoderma lucidum.
Ganoderic acid SZ V94527 Ganoderic acid SZ 865543-37-9 Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity.
Glenvastatin V114372 Glenvastatin 122254-45-9 Glenvastatin (HR 780) is an orally effective 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor.
GR 92549 V112208 GR 92549 144501-27-9 GR 92549 is a potent, orally effective competitive HMG-CoA reductase inhibitor that can be used as a cholesterol-lowering drug.
HMG-CoA Reductase-IN-1 V78583 HMG-CoA Reductase-IN-1 HMG-CoA Reductase-IN-1 is an HMG-CoA reductase inhibitor.
L-157012 V74036 L-157012 114801-28-4 L-157012 is an HMG-CoA reductase (HMGCR) inhibitor.
PF-3052334 V116128 PF-3052334 887702-61-6 PF-3052334 is an orally effective liver-selective HMG-CoA reductase inhibitor with an IC50 value of 1.9 nM.
Phenicin V117761 Phenicin 128-68-7 Phoenicine is a microbial metabolite and an irreversible inhibitor of HMG-CoA reductase (HMGCR).
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