HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate.Eukaryotes and prokaryotes both contain HMGCR. Two classes of HMG-CoA reductase have been identified through phylogenetic analysis: Class I enzymes found in some eukaryotes and archaea and Class II enzymes found in some eubacteria and other archaea.
The enzyme HMGCR is known to catalyze an early reaction specific to isoprenoid biosynthesis in both eukaryotes and archaebacteria. Drugs used to lower serum cholesterol levels frequently target the HMG-CoA reductase reaction because it is rate-limiting for the biosynthesis of cholesterol in humans.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74034 | Bemfivastatin hemicalcium (PPD 10558 hemicalcium) | 805241-64-9 | Bemfivastatin (PPD 10558) hemicalcium is an orally bioactive lipid-lowering agent and HMG-CoA reductase inhibitor. |
|
V74033 | Ganoderenic acid K | 942950-94-9 | Ganoderenic acid K is a naturally occurring compound extracted from the fruiting bodies of Ganoderma lucidum. |
|
V78583 | HMG-CoA Reductase-IN-1 | HMG-CoA Reductase-IN-1 is an HMG-CoA reductase inhibitor. | |
|
V74036 | L-157012 | 114801-28-4 | L-157012 is an HMG-CoA reductase (HMGCR) inhibitor. |
|
V18212 | Lovastatin Sodium | 75225-50-2 | Lovastatin Sodium (Lovastatin hydroxy acid sodium; Mevinolinic acid sodium)is an inhibitor of HMG-CoA reductasewith a Ki of 0.6 nM. |
|
V1859 | Pitavastatin Calcium (NK-104) | 147526-32-7 | Pitavastatin calcium (also called NK-104 Calcium; itavastatin or nisvastatin)is a novel and potent drug of the statin class. |
|
V74035 | Pravastatin lactone (pravastatin ester) | 85956-22-5 | Pravastatin lactone is a potent HMG-CoA inhibitor. |
|
V3296 | Rosuvastatin D6 Sodium | 2070009-41-3 | Rosuvastatin D6 Sodium is deuterium labeled Rosuvastatin (also known as S-4522 and ZD 4522, trade name: Crestor) which is a member of the statin class of drugs and a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
|
V40844 | Rosuvastatin Sodium | 147098-18-8 | Rosuvastatin sodium (formerly S4522; ZD-4522, trade name: Crestor),the sodium salt ofRosuvastatin, is an HMG-CoA reductase inhibitor approved for thetreatment ofhigh cholesterol and related conditions such as dyslipidemia, and to prevent cardiovascular disease. |
|
V4949 | SR12813 | 126411-39-0 | SR12813,a 1,1-bisphosphonate ester, is a novel and potent pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. |
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