HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate.Eukaryotes and prokaryotes both contain HMGCR. Two classes of HMG-CoA reductase have been identified through phylogenetic analysis: Class I enzymes found in some eukaryotes and archaea and Class II enzymes found in some eubacteria and other archaea.

The enzyme HMGCR is known to catalyze an early reaction specific to isoprenoid biosynthesis in both eukaryotes and archaebacteria. Drugs used to lower serum cholesterol levels frequently target the HMG-CoA reductase reaction because it is rate-limiting for the biosynthesis of cholesterol in humans.

HMGCR related products

Structure Cat No. Product Name CAS No. Product Description
Bemfivastatin hemicalcium (PPD 10558 hemicalcium) V74034 Bemfivastatin hemicalcium (PPD 10558 hemicalcium) 805241-64-9 Bemfivastatin (PPD 10558) hemicalcium is an orally bioactive lipid-lowering agent and HMG-CoA reductase inhibitor.
Ganoderenic acid K V74033 Ganoderenic acid K 942950-94-9 Ganoderenic acid K is a naturally occurring compound extracted from the fruiting bodies of Ganoderma lucidum.
HMG-CoA Reductase-IN-1 V78583 HMG-CoA Reductase-IN-1 HMG-CoA Reductase-IN-1 is an HMG-CoA reductase inhibitor.
L-157012 V74036 L-157012 114801-28-4 L-157012 is an HMG-CoA reductase (HMGCR) inhibitor.
Lovastatin Sodium V18212 Lovastatin Sodium 75225-50-2 Lovastatin Sodium (Lovastatin hydroxy acid sodium; Mevinolinic acid sodium)is an inhibitor of HMG-CoA reductasewith a Ki of 0.6 nM.
Pitavastatin Calcium (NK-104) V1859 Pitavastatin Calcium (NK-104) 147526-32-7 Pitavastatin calcium (also called NK-104 Calcium; itavastatin or nisvastatin)is a novel and potent drug of the statin class.
Pravastatin lactone (pravastatin ester) V74035 Pravastatin lactone (pravastatin ester) 85956-22-5 Pravastatin lactone is a potent HMG-CoA inhibitor.
Rosuvastatin D6 Sodium V3296 Rosuvastatin D6 Sodium 2070009-41-3 Rosuvastatin D6 Sodium is deuterium labeled Rosuvastatin (also known as S-4522 and ZD 4522, trade name: Crestor) which is a member of the statin class of drugs and a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
Rosuvastatin Sodium V40844 Rosuvastatin Sodium 147098-18-8 Rosuvastatin sodium (formerly S4522; ZD-4522, trade name: Crestor),the sodium salt ofRosuvastatin, is an HMG-CoA reductase inhibitor approved for thetreatment ofhigh cholesterol and related conditions such as dyslipidemia, and to prevent cardiovascular disease.
SR12813 V4949 SR12813 126411-39-0 SR12813,a 1,1-bisphosphonate ester, is a novel and potent pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.
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