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LPL Receptor

LPL Receptor

Members of the G protein-coupled receptor family of integral membrane proteins, the LPL Receptor (Lysophospholipid Receptor) group are crucial for lipid signaling. There are eight LPL receptors in humans, and different genes each encode one of them. Other names for these LPL receptor genes include "Edg." In the cell membrane, LPL receptor ligands bind to and activate their corresponding receptors. The activated receptor can have a variety of effects on the cell, depending on the ligand, receptor, and type of cell involved. These include primary effects such as adenylyl cyclase inhibition and calcium release from the endoplasmic reticulum, as well as secondary effects such as cell proliferation and apoptosis prevention. Type: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6.

LPL Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(S)-FTY720-phosphonate V75443 (S)-FTY720-phosphonate 1142015-10-8 FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist that may be utilized to study acute inflammation such as acute lung injury.
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA) V75439 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA) 65528-98-5 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid species with high bioactivity due to its strong affinity for LPA receptors.
A6770 V75444 A6770 1331754-16-5 A6770 is an orally bioactive sphingosine-1-phosphate (S1P) lyase (S1PL) inhibitor.
ACT-1016-0707 (LPA1 receptor antagonist 2) V83383 ACT-1016-0707 (LPA1 receptor antagonist 2) 2569467-78-1
AM095 free acid V33497 AM095 free acid 1228690-36-5 AM095 free acid is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively.
AM095 sodium V7134 AM095 sodium 1345614-59-6 AM095 sodium is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively.
Amiselimod hydrochloride (MT-1303 hydrochloride) V75440 Amiselimod hydrochloride (MT-1303 hydrochloride) 942398-84-7 Amiselimod HCl is a novel modulator of the S1P1 receptor.
BMS-986020 V3470 BMS-986020 1257213-50-5 BMS-986020 (also known as AM152 and AP-3152 free acid) is a novel, potent and selective LPA1 (lysophosphatidic acid) antagonist.
C16-Sphingosine-1-phosphate V86656 C16-Sphingosine-1-phosphate 709026-60-8 C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and an endogenous ligand of the EDG/S1P receptor.
CYM-50308 V18990 CYM-50308 1345858-76-5 CYM50308 (ML248) is a potent, selective and high-affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with EC50 of 56 nM.
CYM-5442 V7018 CYM-5442 1094042-01-9 CYM-5442 is anovel, potent and highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist which reduces the severity of acute GVHD by inhibiting macrophage recruitment.
CYM-5541 (ML249) V3237 CYM-5541 (ML249) 945128-26-7 CYM-5541 (also known as ML249) is a potent, selective, full, and allosteric agonist of the S1P3(Sphingosine 1-phosphate) receptor with EC50in the range of 72 to 132 nM.
CYM50358 V75461 CYM50358 1314212-39-9 CYM50358 is a potent and specific S1PR4 antagonist (inhibitor) with IC50 of 25 nM.
Ginkgolic acid 2-phosphate V83454 Ginkgolic acid 2-phosphate 2281761-58-6
GLPG2938 V2475 GLPG2938 2130996-00-6 GLPG2938 is a potent and specific S1P2 antagonist.
GSK2018682 V3553 GSK2018682 1034688-30-6 GSK2018682 is a novel and potent agonist for S1P1 and S1P5 receptor (sphingosine 1 phosphate receptor) with pEC50s of 7.7 and 7.2, respectively, and it has no agonist activity towards human S1P2, S1P3, or S1P4. S1P4.
H2L 5765834 V75454 H2L 5765834 420841-84-5 H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3 and LPA5, with IC50s of 94, 752 and 463 nM respectively.
Icanbelimod (S1p receptor agonist 1) V18417 YUN88562 1514888-56-2 YUN88562, formerly known as S1p receptor agonist 1, is an S1P receptor agonist found in patent WO 2015039587 A1, compound example 2.
KSI-6666 V86660 KSI-6666 1807873-14-8 KSI-6666 is an orally active, competitive sphingosine 1-phosphate receptor 1 (S1PR1) antagonist with an IC50 of 6.4 nM.
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) V75460 L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) 105615-55-2 L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid.
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