Members of the G protein-coupled receptor family of integral membrane proteins, the LPL Receptor (Lysophospholipid Receptor) group are crucial for lipid signaling. There are eight LPL receptors in humans, and different genes each encode one of them. Other names for these LPL receptor genes include "Edg." In the cell membrane, LPL receptor ligands bind to and activate their corresponding receptors. The activated receptor can have a variety of effects on the cell, depending on the ligand, receptor, and type of cell involved. These include primary effects such as adenylyl cyclase inhibition and calcium release from the endoplasmic reticulum, as well as secondary effects such as cell proliferation and apoptosis prevention. Type: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V102616 | (R)-FTY 720P | 402616-23-3 | (R)-FTY 720P is the R isomer of FTY 720P. |
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V113170 | (S)-FTY-720 Vinylphosphonate | 1142015-13-1 | (S)-FTY-720 vinylphosphonate is a chiral phosphonate analog of fingomodide. |
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V75443 | (S)-FTY720-phosphonate | 1142015-10-8 | FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist that may be utilized to study acute inflammation such as acute lung injury. |
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V114599 | (S)-PF-462991 | 1149727-65-0 | (S)-PF-462991 is a direct agonist of S1P1,5. |
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V107821 | 1-Octadecyl lysophosphatidic acid | 52977-29-4 | 1-Octadecanyl lysophosphatidic acid (Compound 10) is a GPR92 receptor (LPA5) activator with potential flavoring properties. |
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V75439 | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA) | 65528-98-5 | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid species with high bioactivity due to its strong affinity for LPA receptors. |
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V118425 | 2ccPA sodium | 927880-40-8 | 2ccPA sodium is a lysophosphatidylcholine (LPA) receptor agonist. |
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V75444 | A6770 | 1331754-16-5 | A6770 is an orally bioactive sphingosine-1-phosphate (S1P) lyase (S1PL) inhibitor. |
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V115980 | AB1 | 1463912-49-3 | AB1 is a highly selective S1P2 receptor antagonist (IC50 = 3.5 nM). |
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V83383 | ACT-1016-0707 (LPA1 receptor antagonist 2) | 2569467-78-1 | |
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V33497 | AM095 free acid | 1228690-36-5 | AM095 free acid is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively. |
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V7134 | AM095 sodium | 1345614-59-6 | AM095 sodium is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively. |
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V120000 | AzoLPA ammonium | 2389048-52-4 | AzoLPA ammonium is a photoswitched lipid that can activate the signal transduction of the lysophosphatidic acid 1-5 (LPA1-5) receptor. |
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V3470 | BMS-986020 | 1257213-50-5 | BMS-986020 (also known as AM152 and AP-3152 free acid) is a novel, potent and selective LPA1 (lysophosphatidic acid) antagonist. |
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V93259 | BMS-986104 | 1622180-31-7 | BMS-986104 is a potent and selective S1P1 receptor modulator. |
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V109636 | BrP-LPA | 944313-05-7 | BrP-LPA is an LPA antagonist/ATX inhibitor. |
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V112109 | BrP-LPA sodium | 944265-88-7 | BrP-LPA sodium is a pan-antagonist of lysophosphatidylcholine (LPA), exhibiting antagonistic activity against LPA1 (IC50 = 4520 nM), LPA2 (IC50 = 468 nM), LPA3, and LPA4. |
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V86656 | C16-Sphingosine-1-phosphate | 709026-60-8 | C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and an endogenous ligand of the EDG/S1P receptor. |
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V105564 | CAY10734 | 635701-59-6 | CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) with IC50 of 1.3 nM. |
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V18990 | CYM-50308 | 1345858-76-5 | CYM50308 (ML248) is a potent, selective and high-affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with EC50 of 56 nM. |
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