| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V40963 | (Rac)-Benpyrine | 1333714-43-4 | Rac)-Benpyrine, the racemic mixture of Benpyrine, is a potent and orally bioactive TNF-α inhibitor with the potential for TNF-α mediated inflammatory and autoimmune disease research. |
|
V6027 | (S)-Tipifarnib | 192185-71-0 | Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, which is a highly efficient and specific inhibitor of farnesyltransferase with IC50 of 0.6 nM. |
|
V6003 | AX-024 HCl | 1704801-24-0 | AX-024 is a novel, potent andorally bioavailable inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 1 nM). |
|
V12729 | Bioymifi | 1420071-30-2 | Bioymifi is an DR5 activator (Kd = 1.2 µM; IC50 = 2 µM). |
|
V30065 | Hispidol | 5786-54-9 | Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
|
V32271 | Homoplantaginin | 17680-84-1 | Homoplantaginin is a naturally occurring flavonoid isolatedfrom Salvia plebeia (a traditional Chinese medicine), exhibits anti-inflammatory and antioxidant activity by inhibitingTNF-α, IL-6mRNA expression, andIKKβandNF-κBphosphorylation. |
|
V10414 | Hypaconitine | 6900-87-4 | Hypaconitine is a highly toxic natural active ingredient extracted from the genus Aconitum and is widely utilized in study/research of rheumatic diseases. |
|
V23299 | KR-33494 | 1021497-97-1 | KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1). |
|
V3781 | LY303511 HCl | 2070014-90-1 | LY303511 is an analog ofLY294002and is also known as NV-128 and EM 101. |
|
V31112 | Mesaconitine | 2752-64-9 | Mesaconitine is the main active ingredient of Aconitum plants and has a variety of pharmaceutical effects. |
|
V0037 | Necrostatin-1 (Nec-1) | 4311-88-0 | Necrostatin-1 (Nec-1) is a novel, potent and specific RIP1 (receptor-interacting protein 1) kinase inhibitor that inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. |
|
V0035 | Pomalidomide (CC4047 or actimid) | 19171-19-8 | Pomalidomide (formerly also known as CC-4047 or actimid), an analog of thalidomide, is a potent andorally bioavailable immunomodulatory molecule with antineoplastic activity. |
|
V0038 | QNZ (EVP4593; CAY10470) | 545380-34-5 | QNZ (also known as EVP-4593 or CAY-10470),a quinazoline derivative, is a novel and potentNF-κB inhibitor, which shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in human Jurkat T cells, respectively. |
|
V13563 | R-7050 | 303997-35-5 | R-7050 (R7050) is a novel, potent and selective tumor necrosis factor/TNF-α receptor antagonist acting by blocking receptor-adaptor molecule complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. |
|
V13666 | REN-1189(CPI-1189) | 183619-38-7 | CPI-1189 is a TNF-α release inhibitor (antagonist) with antioxidant and neuro-protective (neuro-protection) activities. |
|
V14615 | Semapimod tetrahydrochloride | 164301-51-3 | Semapimod 4HCl, thetetrahydrochloride salt ofSemapimod mesylate (AXD 455; AIDS-121302;CNI-1493), is a novel and potentcytokine inhibitor that inhibits the production of proinflammatory cytokines such asTNF-α, IL-1β, and IL-6. |
|
V15104 | SPD-304 | 869998-49-2 | SPD-304 is a novel, potent and selective inhibitor of tumor necrosis factor α (TNFα) withan IC50 of 22 µM forpreventing binding to the TNF Receptor 1 (TNFR1). |
|
V0036 | Thalidomide (Immunoprin, Contergan and Thalomid) | 50-35-1 | Thalidomide (trade names Immunoprin, Contergan and Thalomid among others) is a potent immunomodulatory agent and a drug approved in the 1950s. |
|
V40171 | UCB-9260 | 1515888-53-5 | UCB-9260 (UCB9260; UCB 9260) is an oral anti-inflammatory agent with the potential to treat autoimmune diseases such as rheumatoid arthritis and Crohns disease. |
|
V15441 | UTL-5g | 646530-37-2 | UTL-5g (GBL-5g) is an anti~inflammatory TNF-α inhibitor (antagonist) with chemoprotective and hepatoradioprotective effects. |
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