TNFa

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TNFa

TNFa related products

Cat No.	Product Name	CAS No.	Product Description
V40963	(Rac)-Benpyrine	1333714-43-4	Rac)-Benpyrine, the racemic mixture of Benpyrine, is a potent and orally bioactive TNF-α inhibitor with the potential for TNF-α mediated inflammatory and autoimmune disease research.
V15104	SPD-304	869998-49-2	SPD-304 is a novel, potent and selective inhibitor of tumor necrosis factor α (TNFα) withan IC50 of 22 µM forpreventing binding to the TNF Receptor 1 (TNFR1).
V6003	AX-024 HCl	1704801-24-0	AX-024 is a novel, potent andorally bioavailable inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 1 nM).
V12729	Bioymifi	1420071-30-2	Bioymifi is an DR5 activator (Kd = 1.2 µM; IC50 = 2 µM).
V30065	Hispidol	5786-54-9	Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.
V23299	KR-33494	1021497-97-1	KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
V3781	LY303511 HCl	2070014-90-1	LY303511 is an analog ofLY294002and is also known as NV-128 and EM 101.
V0038	QNZ (EVP4593; CAY10470)	545380-34-5	QNZ (also known as EVP-4593 or CAY-10470),a quinazoline derivative, is a novel and potentNF-κB inhibitor, which shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in human Jurkat T cells, respectively.
V13563	R-7050	303997-35-5	R-7050 (R7050) is a novel, potent and selective tumor necrosis factor/TNF-α receptor antagonist acting by blocking receptor-adaptor molecule complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding.
V13666	REN-1189(CPI-1189)	183619-38-7	CPI-1189 is a TNF-α release inhibitor (antagonist) with antioxidant and neuro-protective (neuro-protection) activities.
V40171	UCB-9260	1515888-53-5	UCB-9260 (UCB9260; UCB 9260) is an oral anti-inflammatory agent with the potential to treat autoimmune diseases such as rheumatoid arthritis and Crohns disease.
V15441	UTL-5g	646530-37-2	UTL-5g (GBL-5g) is an anti~inflammatory TNF-α inhibitor (antagonist) with chemoprotective and hepatoradioprotective effects.
V10414	Hypaconitine	6900-87-4	Hypaconitine is a highly toxic natural active ingredient extracted from the genus Aconitum and is widely utilized in study/research of rheumatic diseases.
V31112	Mesaconitine	2752-64-9	Mesaconitine is the main active ingredient of Aconitum plants and has a variety of pharmaceutical effects.
V0037	Necrostatin-1 (Nec-1)	4311-88-0	Necrostatin-1 (Nec-1) is a novel, potent and specific RIP1 (receptor-interacting protein 1) kinase inhibitor that inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.
V14615	Semapimod tetrahydrochloride	164301-51-3	Semapimod 4HCl, thetetrahydrochloride salt ofSemapimod mesylate (AXD 455; AIDS-121302;CNI-1493), is a novel and potentcytokine inhibitor that inhibits the production of proinflammatory cytokines such asTNF-α, IL-1β, and IL-6.
V6027	(S)-Tipifarnib	192185-71-0	Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, which is a highly efficient and specific inhibitor of farnesyltransferase with IC50 of 0.6 nM.
V0036	Thalidomide (Immunoprin, Contergan and Thalomid)	50-35-1	Thalidomide (trade names Immunoprin, Contergan and Thalomid among others) is a potent immunomodulatory agent and a drug approved in the 1950s.
V0035	Pomalidomide (CC4047 or actimid)	19171-19-8	Pomalidomide (formerly also known as CC-4047 or actimid), an analog of thalidomide, is a potent andorally bioavailable immunomodulatory molecule with antineoplastic activity.
V32271	Homoplantaginin	17680-84-1	Homoplantaginin is a naturally occurring flavonoid isolatedfrom Salvia plebeia (a traditional Chinese medicine), exhibits anti-inflammatory and antioxidant activity by inhibitingTNF-α, IL-6mRNA expression, andIKKβandNF-κBphosphorylation.