Procollagen C proteinase (PCP) and its enhancer protein (PCPE) are key to collagen fibril-assembly and extracellular matrix formation. The carboxyl-propeptides of procollagen types I, II, and III are broken down by PCP, which starts the formation of collagen fibrils on its own. Pro-lysyl oxidase, laminin 5, and type V procollagen N-propeptides may also be broken down by PCP. PCPE, a glycoprotein that binds to the C-propeptide of type I procollagen through its N-terminal CUB domains, stimulates PCP's processing of procollagen. TGF-like growth factors can be activated by proteases related to PCP/BMP-1. In addition to their function in the formation of collagen fibrils, PCPs perform significant biological tasks.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V123137 | 12-O-Tiglyl-phorbol 13-dodecanoate | 37394-32-4 | 12-O-Tiglyl-phorbol 13-dodecanoate is a potential inhibitor with anti-hepatic fibrosis activity and belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis drugs. |
|
V130378 | Bletimalate C | Bletimalate C is a 2-isobutyl malate found in the tubers of Bletilla striata. | |
|
V146681 | Type IV collagen peptide | 119975-51-8 | Type IV collagen peptide is a cell-binding ligand peptide derived from type IV collagen. |
|
V27826 | UK-383367 | 348622-88-8 | UK-383367 (UK383367; UK 383367) is a novel and potent nonpeptide inhibitor of BMP-1(bone morphogenetic protein 1, also called procollagen C-proteinase; PCP) with dermal anti-scarring activity. |
|
V146953 | Vezocolmitide | 51486-77-2 | Vezocolmitide is a collagen mimic peptide. |
|
V147158 | WYRGRLC | 1027630-05-2 | WYRGRLC is a peptide that targets type II collagen. |
|
V147791 | Collagen, Type III, from fish intestine | 9007-34-5 | Type III collagen is a protein that may treat osteoarthritis. |
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