Trk receptor

Trk receptor

Trk receptors are a family of three receptor tyrosine kinases (TrkA, TrkB, and TrkC), each of which can be activated by one or more of the four neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).

The TRK receptor family is made up of the transmembrane proteins TrkA, TrkB, and TrkC. These receptor tyrosine kinases are expressed in human neuronal tissue and are crucial for the physiology of nervous system development and function. Neurotrophins (NTs) activate these receptor tyrosine kinases. For TrkA, BDGF, NT-4/5, and TrkB and TrkC, respectively, these latter substances are specific ligands known as NGF and NT-3.

When a ligand binds to a receptor, the receptors begin to oligomerize and certain tyrosine residues in the intracytoplasmic kinase domain become phosphorylated. As a result of this action, signal transduction pathways that promote proliferation, differentiation, and survival in both healthy and malignant neuronal cells are activated.

Trk receptor related products

Structure Cat No. Product Name CAS No. Product Description
V69602 (3aR)-Selitrectinib ((3aR)-LOXO-195) 1350884-56-8 (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isomer of Selitrectinib.
V78306 1D228 1D228 is a c-Met/TRK inhibitor (antagonist) with anti-tumor activity.
V69587 2-Bromo-6-methoxynaphthalene 5111-65-9 2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents such as Naproxen and Nabumetone via the Heck reaction.
V69583 Amitriptyline-d3 hydrochloride 342611-00-1 Amitriptyline-d3 HCl is the deuterated form of Amitriptyline ( HCl).
V69600 Amitriptyline-d6 hydrochloride (amitriptyline d6 hydrochloride) 203645-63-0 Amitriptyline-d6 ( HCl) is the deuterated form of Amitriptyline HCl.
V0642 ANA-12 219766-25-3 ANA-12 (ANA12) is a novel, potent and selective TrkB inhibitor/antagonist with important biological activity.
V69592 Anizatrectinib (hTrkA-IN-1) 1824664-89-2 Anizatrectinib (hTrkA-IN-1) is a potent oral TrkA kinase inhibitor (antagonist) with IC50 of 1.3 nM, compound 2.
V69590 Bedinvetmab (ZTS-00508841) 2171034-69-6 Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) directed against nerve growth factor (NGF).
V85019 CG428 2412055-93-5
V4146 CH7057288 2095616-82-1 CH7057288 is a novel, potent and selectiveinhibitor of TRK (tyrosine receptor kinase) with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.
V69581 Cyclotraxin B 1203586-72-4 Cyclotraxin B is a cyclic peptide that is a potent and specific TrkB inhibitor (antagonist) without altering BDNF binding.
V78959 Cyclotraxin B TFA Cyclotraxin B TFA is a cyclic peptide that is a potent and specific TrkB inhibitor (antagonist) without altering BDNF binding.
V69601 ENT-C225 2919962-53-9 ENT-C225 is a potent activator of the TrkB neurotrophin receptor.
V85257 Gambogic amide 286935-60-2
V0641 GNF-5837 1033769-28-6 GNF-5837 (GNF5837) is an orally bioavailable pan-TRK (TrkA, TrkB)inhibitor with potential antitumor activity.
V69586 GNF-8625 monopyridin-N-piperazine hydrochloride 2412055-62-8 GNF-8625 monopyridin-N-piperazine HCl (TRKi-2) is an inhibitor (blocker/antagonist) of TRK, information is from patent WO 2020038415 A1.
V0640 GW441756 504433-23-2 GW441756 (GW-441756) is a novel, potent and selective inhibitor of TrkA (Tropomyosin-related kinase A) with potential anticancer activity.
V2683 Larotrectinib (LOXO-101; ARRY-470) 1223403-58-4 Larotrectinib (LOXO-101; LOXO101; ARRY470;ARRY-470; Vitrakvi)is an orally bioactive, highly selective, ATP competitive TRK inhibitor with potential anticancer activity.
V2599 Larotrectinib sulfate (LOXO-101; ARRY-470) 1223405-08-0 Larotrectinib sulfate (LOXO-101; ARRY-470; Vitrakvi), the suldate salt of Larotrectinib,is a potent, oral, selective, ATP competitive TRK inhibitor with IC50s in low nanomolar range (2 to 20 nM) for inhibition of all TRK family members in binding and cellular assays.
V30834 LM22B-10 342777-54-2 LM22B-10 (LM22B10) is a novel, potent activator of TrkB/TrkC (Tropomyosin-receptor kinase) neurotrophin receptor, inducing TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
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