Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74752 | (1S)-CCR2 antagonist 1 | 1683534-97-5 | (1S)-CCR2 antagonist 1 is the left-handed chiral form of CCR2 antagonist 1. |
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V3644 | Aplaviroc | 461443-59-4 | Aplaviroc (formerly known as AK-602; GW-873140; ONO-4128; GW873140A; GSK-873140), a SDP (spirodiketopiperazine) derivative, is a CCR5 entry inhibitor with the potential treatment of HIV infection. |
|
V3645 | Aplaviroc HCl | 461023-63-2 | Aplaviroc HCl (GW873140A; ONO-4128; AK-602; GSK 873140) is the hydrochloride salt of Aplaviroc which is a SDP (spirodiketopiperazine) derivative, and a CCR5 entry inhibitor with anti-HIV activity. |
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V12083 | AZD 4818 | 1003566-93-5 | AZD 4818 (AZD-4818) is a novel and potent chemokine recptor CCR1 antagonist with the potential to be used for the treatment of COPD/chronic obstructive pulmonary disease. |
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V74754 | AZD2098 | 566203-88-1 | AZD2098 is a potent and specific CCR4 inhibitor (antagonist) with CCR4 pIC50s values of 7.8, 8.0, 8.0, and 7.6 in humans, rats, mice, and dogs respectively, and may be utilized in asthma research. |
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V51104 | BAY-3153 | 2771319-69-6 | BAY-3153 is a selective CCR1 (CC motif chemokine receptor 1) antagonist (humIC50=3 nM; rat IC50=11 nM; mice IC50=81 nM). |
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V51105 | Bertilimumab (CAT-213; iCo-008) | 375348-49-5 | Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody (mAb) that can inhibit eotaxin-1 (CCL11). |
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V2026 | Bindarit (AF2838) | 130641-38-2 | Bindarit (also known as AF-2838; AF 2838) is a potent and selective inhibitor of monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory activity. |
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V51102 | BMS-753426 | 1004536-52-0 | BMS-753426 is an orally bioavailable CCR2 antagonist. |
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V3488 | BMS-813160 | 1286279-29-5 | BMS-813160 (BMS813160) is a novel, potent, selective and dual antagonist of CCR2/CCR5 (CC chemokine receptor) with potential immunomodulating and antineoplastic activities. |
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V3785 | BX-471 HCl | 288262-96-4 | BX471 HCl (also known as BX-471; ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1)with potential anti-inflammatory activity. |
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V3022 | BX471 | 217645-70-0 | BX471 (also known as ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1) with Ki of 1 nM for human CCR1, and it may be useful in the treatment of chronic inflammatory diseases. |
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V51097 | Carlumab (CNTO-888) | 915404-94-3 | Carlumab (CNTO 888) is a high-affinity humanized anti-CCL2 (chemokine ligand 2) antibody. |
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V51116 | CCR1 antagonist 6 | 2436773-01-0 | CCR1 antagonist 6 (compound 16q) is an antagonist of CCR1 with IC50 of 3 nM. |
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V51115 | CCR1 antagonist 7 | 2446154-74-9 | CCR1 antagonist 7 (compound 16r) is an antagonist of CCR1 with IC50 of 4 nM. |
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V51111 | CCR4 antagonist 3-1 | 1957-01-3 | CCR4 Antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist (inhibitor) with IC50 of 1.7 μM for [125I]TARC (thymic and activation-regulated chemokine). |
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V51098 | CCR4-IN-38 (CCR4-351) | 2174938-70-4 | CCR4 antagonist |
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V51099 | CCR4-IN-38 (CCR4-351) HCl | 2174938-71-5 | CCR4 antagonist |
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V51113 | CCR5 antagonist 2 | 1800570-93-7 | CCR5 Antagonist 2 (Compound 25) is a CCR5 antagonist (inhibitor) with IC50 of 8.34 nM. |
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V51112 | CCR5 antagonist 3 | 1800570-92-6 | CCR5 Antagonist 3 (Compound 26) is a CCR5 antagonist (inhibitor) with IC50 of 15.90 nM. |
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