CCR

CCR

Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.

CCR related products

Structure Cat No. Product Name CAS No. Product Description
V74752 (1S)-CCR2 antagonist 1 1683534-97-5
V3644 Aplaviroc 461443-59-4 Aplaviroc (formerly known as AK-602; GW-873140; ONO-4128; GW873140A; GSK-873140), a SDP (spirodiketopiperazine) derivative, is a CCR5 entry inhibitor with the potential treatment of HIV infection.
V3645 Aplaviroc HCl 461023-63-2 Aplaviroc HCl (GW873140A; ONO-4128; AK-602; GSK 873140) is the hydrochloride salt of Aplaviroc which is a SDP (spirodiketopiperazine) derivative, and a CCR5 entry inhibitor with anti-HIV activity.
V12083 AZD 4818 1003566-93-5 AZD 4818 (AZD-4818) is a novel and potent chemokine recptor CCR1 antagonist with the potential to be used for the treatment of COPD/chronic obstructive pulmonary disease.
V74754 AZD2098 566203-88-1
V51104 BAY-3153 2771319-69-6 CCR1 antagonist
V51105 Bertilimumab (CAT-213; iCo-008) 375348-49-5 humanized anti-eotaxin-1 monoclonal antibody
V2026 Bindarit (AF2838) 130641-38-2 Bindarit (also known as AF-2838; AF 2838) is a potent and selective inhibitor of monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory activity.
V51102 BMS-753426 1004536-52-0 CCR2 antagonist
V3488 BMS-813160 1286279-29-5 BMS-813160 (BMS813160) is a novel, potent, selective and dual antagonist of CCR2/CCR5 (CC chemokine receptor) with potential immunomodulating and antineoplastic activities.
V3785 BX-471 HCl 288262-96-4 BX471 HCl (also known as BX-471; ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1)with potential anti-inflammatory activity.
V3022 BX471 217645-70-0 BX471 (also known as ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1) with Ki of 1 nM for human CCR1, and it may be useful in the treatment of chronic inflammatory diseases.
V51097 Carlumab (CNTO-888) 915404-94-3 humanized anti-CCL2 antibody
V51116 CCR1 antagonist 6 2436773-01-0 CCR1 antagonist
V51115 CCR1 antagonist 7 2446154-74-9 CCR1 antagonist
V51111 CCR4 antagonist 3-1 1957-01-3 CCR4 antagonist
V51098 CCR4-IN-38 (CCR4-351) 2174938-70-4 CCR4 antagonist
V51099 CCR4-IN-38 (CCR4-351) HCl 2174938-71-5 CCR4 antagonist
V51113 CCR5 antagonist 2 1800570-93-7 CCR5 antagonist
V51112 CCR5 antagonist 3 1800570-92-6 CCR5 antagonist
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