Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74752 | (1S)-CCR2 antagonist 1 | 1683534-97-5 | (1S)-CCR2 antagonist 1 is the left-handed chiral form of CCR2 antagonist 1. |
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V114838 | (S)-IDOR-1117-2520 | (S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520. | |
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V128053 | ABT-182 | ABT-182 is an antibody targeting human CCR8. | |
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V85247 | ALK4290 dihydrochloride (AKST4290 dihydrochloride) | 1372127-19-9 | |
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V128997 | Anti-CCL2 (Carlumab)-McMMAF | Anti-CCL2 (Carlumab)-McMMAF is an antibody-drug conjugate (ADC) composed of a humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab, a protective group maleimidocaproyl, and a microtubule inhibitor MMAF. | |
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V129000 | Anti-CCL2 (Carlumab)-SMCC-DM1 | Anti-CCL2 (Carlumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) composed of a humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab conjugated with the linker SMCC and the cytotoxic microtubule inhibitor DM1. | |
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V129001 | Anti-CCL2 (Carlumab)-SPDB-DM4 | Anti-CCL2 (Carlumab)-SPDB-DM4 is an antibody-drug conjugate (ADC) composed of a humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab conjugated with the linker SPDB and the microtubule inhibitor DM4. | |
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V129002 | Anti-CCL2 (Carlumab)-VcMMAE | Anti-CCL2 (Carlumab)-VcMMAE is an antibody-drug conjugate (ADC) consisting of a humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab conjugated with valine-citrulline (VC) and bound to the microtubule inhibitor MMAE. | |
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V129564 | AT008 | AT008 is an anti-GPCR monoclonal antibody that blocks the binding of chemokine ligands to their cell surface receptor CCR4. | |
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V86577 | AZ760 | 912461-36-0 | AZ760 is a CCR8 antagonist. |
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V12083 | AZD 4818 | 1003566-93-5 | AZD 4818 (AZD-4818) is a novel and potent chemokine recptor CCR1 antagonist with the potential to be used for the treatment of COPD/chronic obstructive pulmonary disease. |
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V74754 | AZD2098 | 566203-88-1 | AZD2098 is a potent and specific CCR4 inhibitor (antagonist) with CCR4 pIC50s values of 7.8, 8.0, 8.0, and 7.6 in humans, rats, mice, and dogs respectively, and may be utilized in asthma research. |
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V106386 | Azirkitug | Azirkitug is an IgG1κ humanized antibody targeting CCR8. | |
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V51104 | BAY-3153 | 2771319-69-6 | BAY-3153 is a selective CCR1 (CC motif chemokine receptor 1) antagonist (humIC50=3 nM; rat IC50=11 nM; mice IC50=81 nM). |
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V102568 | BMS-681 | 847998-92-9 | BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). |
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V51102 | BMS-753426 | 1004536-52-0 | BMS-753426 is an orally bioavailable CCR2 antagonist. |
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V3488 | BMS-813160 | 1286279-29-5 | BMS-813160 (BMS813160) is a novel, potent, selective and dual antagonist of CCR2/CCR5 (CC chemokine receptor) with potential immunomodulating and antineoplastic activities. |
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V3785 | BX-471 HCl | 288262-96-4 | BX471 HCl (also known as BX-471; ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1)with potential anti-inflammatory activity. |
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V3022 | BX471 | 217645-70-0 | BX471 (also known as ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1) with Ki of 1 nM for human CCR1, and it may be useful in the treatment of chronic inflammatory diseases. |
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V106387 | Cafelkibart | Cafelkibart is an IgG1κ chimeric antibody targeting CCR8. |
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