Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates.The majority of aminopeptidases have metallo-enzymes as their catalytic mechanism, but cysteine and serine peptidases are also a part of this class. Aminopeptidases are present in a variety of subcellular organelles, the cytoplasm, and membrane components throughout the animal and plant kingdoms. Numerous aminopeptidases carry out vital cellular tasks. These peptidases include many zinc metalloenzymes, but not all of them, and the transition-state analog bestatin inhibits them all. Some are monomeric, while others are collections of subunits with a relatively high mass (50 kDa).
The corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN), and insulin-regulated aminopeptidase (IRAP) can be used to analyze the functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade. These enzyme processes result in active or inactive angiotensin peptides, which change the ratios between their bioactive forms and control a number of critical processes, including the regulation of cardiovascular functions, the regulation of body water, normal memory consolidation and retrieval, but also cell growth, differentiation, and apoptosis or the inflammatory response.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2842 | Acebilustat | 943764-99-6 | Acebilustat, also known as ZK322, is a novel, oral, potent and selective leukotriene A4 hydrolase inhibitor that is a promising new once-daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. |
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V72984 | Aminopeptidase N Ligand (CD13) NGR peptide | 760947-20-4 | Aminopeptidase N Ligand (CD13) NGR peptide is a CD13-targeting peptide that serves as a carrier to mediate intracellular delivery. |
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V72986 | Aminopeptidase-IN-1 | 374102-08-6 | Aminopeptidase-IN-1 (compound 16o) is a potent insulin-regulated aminopeptidase (IRAP) inhibitor (antagonist) with Ki of 7.7 μM. |
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V2498 | Bestatin (Ubenimex) | 58970-76-6 | Bestatin (also called Ubenimex; NK421; NSC 265489)is a potent, naturally occuring and broad-spectrum aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor used in the treatment of acute myelocytic leukemia. |
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V72983 | EC33 | 232261-88-0 | EC33 is a selective aminopeptidase A (APA) inhibitor. |
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V72988 | H-Leu-Trp-Met-Arg-OH | 67368-23-4 | H-Leu-Trp-Met-Arg-OH is a tetrapeptide. |
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V72985 | HD-Ala-D-Ala-D-Ala-D-Ala-OH | 926-78-3 | H-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate of D-aminopeptidase. |
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v2220 | LYS 006 | 1799681-85-8 | LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase LTA4H with IC50 of 2 nM. |
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V72987 | Methyl arachidate (Methyl eicosanoate) | 1120-28-1 | Methyl arachidate (Methyl eicosanoate) is a natural compound that is an inhibitor (blocker/antagonist) of leukotriene A4 hydrolase (LTA4H). |
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V72989 | NGR peptide | 651328-78-8 | NGR peptides are peptides containing the Asn-Gly-Arg (NGR) motif. |
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V76705 | NGR peptide Trifluoroacetate | NGR peptide Trifluoroacetate is a bioactive peptide containing the Asn-Gly-Arg (NGR) motif. | |
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V5082 | Tosedostat (CHR-2797) | 238750-77-1 | Tosedostat (CHR2797) is a novel, orally bioavailable and potent inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. |
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V27773 | Ubenimex HCl | 65391-42-6 | Ubenimex HCl (Bestatin hydrochloride) is a novel and potent CD13 inhibitor orAminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor with the potential to be used for cancer treatment. |
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