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Aminopeptidase

Aminopeptidase

Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates.The majority of aminopeptidases have metallo-enzymes as their catalytic mechanism, but cysteine and serine peptidases are also a part of this class. Aminopeptidases are present in a variety of subcellular organelles, the cytoplasm, and membrane components throughout the animal and plant kingdoms. Numerous aminopeptidases carry out vital cellular tasks. These peptidases include many zinc metalloenzymes, but not all of them, and the transition-state analog bestatin inhibits them all. Some are monomeric, while others are collections of subunits with a relatively high mass (50 kDa).

The corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN), and insulin-regulated aminopeptidase (IRAP) can be used to analyze the functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade. These enzyme processes result in active or inactive angiotensin peptides, which change the ratios between their bioactive forms and control a number of critical processes, including the regulation of cardiovascular functions, the regulation of body water, normal memory consolidation and retrieval, but also cell growth, differentiation, and apoptosis or the inflammatory response.

Aminopeptidase related products

Structure Cat No. Product Name CAS No. Product Description
2-(2′-Pyridyl)benzimidazole V106533 2-(2′-Pyridyl)benzimidazole 1137-68-4 2-(2'-Pyridyl)benzimidazole is a potential tridentate ligand that can form stable complexes with a variety of transition metal ions.
4-MDM V106845 4-MDM 834-14-0 4-MDM (4-methoxydiphenylmethane) is an orally available anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H).
Aminopeptidase N Ligand (CD13) NGR peptide V72984 Aminopeptidase N Ligand (CD13) NGR peptide 760947-20-4 Aminopeptidase N Ligand (CD13) NGR peptide is a CD13-targeting peptide that serves as a carrier to mediate intracellular delivery.
Aminopeptidase-IN-1 V72986 Aminopeptidase-IN-1 374102-08-6 Aminopeptidase-IN-1 (compound 16o) is a potent insulin-regulated aminopeptidase (IRAP) inhibitor (antagonist) with Ki of 7.7 μM.
Apstatin V87297 Apstatin 160470-73-5 Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6 and 0.64 µM for rat and human APP respectively.
Bestatin methyl ester V87296 Bestatin methyl ester 65322-89-6 Bestatin methyl ester is a cell-permeable inhibitor of Zn2+-binding aminopeptidases.
EC33 V72983 EC33 232261-88-0 EC33 is a selective aminopeptidase A (APA) inhibitor.
ERAP1-IN-3 V104878 ERAP1-IN-3 ERAP1-IN-3 (Compound 13) is a potent endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor with a pIC50 value of 8.6.
H-Leu-Trp-Met-Arg-OH V72988 H-Leu-Trp-Met-Arg-OH 67368-23-4 H-Leu-Trp-Met-Arg-OH is a tetrapeptide.
HD-Ala-D-Ala-D-Ala-D-Ala-OH V72985 HD-Ala-D-Ala-D-Ala-D-Ala-OH 926-78-3 H-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate of D-aminopeptidase.
HFI-437 V85031 HFI-437 1110650-74-2
IRAP-IN-1 V87295 IRAP-IN-1 IRAP-IN-1 (compound 3) is a potent and selective insulin regulated aminopeptidase (IRAP) inhibitor with IC50 of 157 nM.
JNJ-40929837 V86059 JNJ-40929837 1191044-42-4
LTA4H-IN-2 V85897 LTA4H-IN-2 2851480-52-7
LTA4H-IN-3 V87293 LTA4H-IN-3 2707473-09-2 LTA4H-IN-3 (compound 9) is a LTA4H inhibitor with IC50 of 28 nM.
LTA4H-IN-4 V87294 LTA4H-IN-4 LTA4H-IN-4 (compound 3) is an orally active LTA4H inhibitor.
LTA4H-IN-5 V87292 LTA4H-IN-5 LTA4H-IN-5 (Compound H122) is an orally available inhibitor of leukotriene A4 hydrolase (LTA4H), inhibiting LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM, respectively.
LYS 006 v2220 LYS 006 1799681-85-8 LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase LTA4H with IC50 of 2 nM.
LYS006 hydrochloride V103150 LYS006 hydrochloride 2619563-79-8 LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase LTA4H with IC50 of 2 nM.
Methyl arachidate (Methyl eicosanoate) V72987 Methyl arachidate (Methyl eicosanoate) 1120-28-1 Methyl arachidate (Methyl eicosanoate) is a natural compound that is an inhibitor (blocker/antagonist) of leukotriene A4 hydrolase (LTA4H).
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