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Aminopeptidase

Aminopeptidase

Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates.The majority of aminopeptidases have metallo-enzymes as their catalytic mechanism, but cysteine and serine peptidases are also a part of this class. Aminopeptidases are present in a variety of subcellular organelles, the cytoplasm, and membrane components throughout the animal and plant kingdoms. Numerous aminopeptidases carry out vital cellular tasks. These peptidases include many zinc metalloenzymes, but not all of them, and the transition-state analog bestatin inhibits them all. Some are monomeric, while others are collections of subunits with a relatively high mass (50 kDa).

The corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN), and insulin-regulated aminopeptidase (IRAP) can be used to analyze the functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade. These enzyme processes result in active or inactive angiotensin peptides, which change the ratios between their bioactive forms and control a number of critical processes, including the regulation of cardiovascular functions, the regulation of body water, normal memory consolidation and retrieval, but also cell growth, differentiation, and apoptosis or the inflammatory response.

Aminopeptidase related products

Structure Cat No. Product Name CAS No. Product Description
(rac)-BDM88951 V122003 (rac)-BDM88951 (rac)-BDM88951 is the racemic form of BDM88951.
2-(2′-Pyridyl)benzimidazole V106533 2-(2′-Pyridyl)benzimidazole 1137-68-4 2-(2'-Pyridyl)benzimidazole is a potential tridentate ligand that can form stable complexes with a variety of transition metal ions.
4-MDM V106845 4-MDM 834-14-0 4-MDM (4-methoxydiphenylmethane) is an orally available anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H).
Aminopeptidase I, Streptomyces griseus V110235 Aminopeptidase I, Streptomyces griseus Streptomyces aminopeptidase I (EC 3.4.11.22) has broad substrate specificity and can remove N-terminal residues from most proteins, except when the penultimate residue is an imino acid.
Aminopeptidase M, Porcine V110157 Aminopeptidase M, Porcine Porcine aminopeptidase M (EC 3.4.11.2) is a metalloproteinase that hydrolyzes almost all N-terminal amino acids of unsubstituted oligopeptides.
Aminopeptidase N inhibitor 1 V128746 Aminopeptidase N inhibitor 1 596108-59-7 Aminopeptidase N inhibitor 1 is an aminopeptidase N inhibitor with an IC50 of 25 μM.
Aminopeptidase N inhibitor 2 V128747 Aminopeptidase N inhibitor 2 Aminopeptidase N inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor activity.
Aminopeptidase N Ligand (CD13) NGR peptide V72984 Aminopeptidase N Ligand (CD13) NGR peptide 760947-20-4 Aminopeptidase N Ligand (CD13) NGR peptide is a CD13-targeting peptide that serves as a carrier to mediate intracellular delivery.
Aminopeptidase-IN-1 V72986 Aminopeptidase-IN-1 374102-08-6 Aminopeptidase-IN-1 (compound 16o) is a potent insulin-regulated aminopeptidase (IRAP) inhibitor (antagonist) with Ki of 7.7 μM.
Antimalarial agent 55 V129084 Antimalarial agent 55 Antimalarial agent 55 is an orally effective inhibitor of PfA-M1 and PfA-M17 aminopeptidases of Plasmodium falciparum, with Ki values of 27 nM and 81 nM, respectively.
Antiparasitic agent-40 V129142 Antiparasitic agent-40 65655-84-7 Antiparasitic agent-40 is a 4-thiazolidinone-based inhibitor of leishmaniasis.
Apstatin V87297 Apstatin 160470-73-5 Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6 and 0.64 µM for rat and human APP respectively.
Apstatin TFA V129309 Apstatin TFA Apstatin TFA is a potent inhibitor of aminopeptidase P (APP), with Ki values of 2.6 and 0.64 µM for rats and humans, respectively.
Arphamenine A V129456 Arphamenine A 96551-81-4 Arphamenine A is an aminopeptidase B inhibitor found in Chromobacterium violaceum HMG361-CF4.
BDM88951 V129961 BDM88951 2790420-60-7 BDM88951 is a selective ERAP2 inhibitor with an IC50 value of 19 nM.
BDM_92499 V129959 BDM_92499 BDM_92499 is a nanomolar selective IRAP inhibitor with an IC50 of 3.4 nM.
Bestatin methyl ester V87296 Bestatin methyl ester 65322-89-6 Bestatin methyl ester is a cell-permeable inhibitor of Zn2+-binding aminopeptidases.
Bestatin-d10 V130071 Bestatin-d10 Bestatin-d10 is the deuterated form of Bestatin.
CD13-IN-1 V131216 CD13-IN-1 CD13-IN-1 is a CD13 inhibitor with an IC50 of 1.71 μM.
Cyanostatin B V118429 Cyanostatin B 850131-23-6 Cyanostatin B is a leucine aminopeptidase (LAP) inhibitor (IC50 = 12 ng/mL).
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