Methionine adenosyltransferases (MATs), also referred to as S-Adenosylmethionine synthetases, are crucial for life because they catalyze the synthesis of S-adenosylmethionine, one of the most significant and pivotal biological molecules. The biological methyl donor necessary for a wide range of cell reactions is S-adenosylmethionine. The catalytic subunits of the MAT isoenzymes, MAT1 and MAT2, are encoded by two genes in mammalian systems, MAT1A and MAT2A, respectively. A third gene, MAT2B, produces the regulatory subunit MAT, which regulates the activity of MAT2 and is encoded by this gene. While MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal liver cells (such as hepatic stellate and Kupffer cells), MAT1A, which is primarily expressed in hepatocytes, maintains the differentiated state of these cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2489 | AG-270 | 2201056-66-6 | AG 270 (AG-270; AG270) is a novel, first-in-class, reversible, allosteric, noncompetitiveand orally bioactiveMAT2Ainhibitor(IC50=14 nM) with anticancer activity. |
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V2253 | FIDAS-5 | 1391934-98-7 | FIDAS-5 is a potent orally bioactive methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of 2.1 μM. |
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V39070 | FIDAS-5 HCl | 1391934-98-7 | FIDAS-5 HCl is a potent orally bioactive methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of 2.1 μM. |
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V10451 | MAT2A inhibitor 2 | 13299-99-5 | MAT2A inhibitor 2 HCl salt is a novel and potent inhibitor of methionine adenosyltransferase 2A (MAT2A) with potential anticancer activity. |
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V51811 | MAT2A inhibitor 3 | 2439271-82-4 | MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of <200 nM. |
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V51810 | MAT2A inhibitor 4 | 1391934-91-0 | MAT2A inhibitor 4 is an inhibitor (blocker/antagonist) of methionine S-adenosyltransferase-2 catalytic subunit (MAT2A). |
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V51812 | MAT2A-IN-10 | 2924825-23-8 | MAT2A-IN-10 (Compound 28) is an orally bioactive MAT2A inhibitor (antagonist) with IC50 of 26 nM. |
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V79758 | MAT2A-IN-11 | MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with IC50 of 6.8 nM. | |
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V56101 | MAT2A-IN-12 | 631897-75-1 | MAT2A Allosteric inhibitor 2 is a potent and specific allosteric inhibitor of MAT2A with IC50 of 5 nM. |
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V85860 | MAT2A-IN-13 | 2851449-24-4 | |
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V53126 | MAT2A-IN-9 | 2439277-80-0 | MAT2A-IN-9 (compound 167) is a 2-oxoquinazoline analogue and a potent MAT2A (methionine adenosyltransferase 2A) inhibitor. |
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V3386 | PF-9366 | 72882-78-1 | PF-9366 (PF9366) is a novel, potent and allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A) with anticancer activity. |
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