MAT

MAT

Methionine adenosyltransferases (MATs), also referred to as S-Adenosylmethionine synthetases, are crucial for life because they catalyze the synthesis of S-adenosylmethionine, one of the most significant and pivotal biological molecules. The biological methyl donor necessary for a wide range of cell reactions is S-adenosylmethionine. The catalytic subunits of the MAT isoenzymes, MAT1 and MAT2, are encoded by two genes in mammalian systems, MAT1A and MAT2A, respectively. A third gene, MAT2B, produces the regulatory subunit MAT, which regulates the activity of MAT2 and is encoded by this gene. While MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal liver cells (such as hepatic stellate and Kupffer cells), MAT1A, which is primarily expressed in hepatocytes, maintains the differentiated state of these cells.

MAT related products

Structure Cat No. Product Name CAS No. Product Description
V2489 AG-270 2201056-66-6 AG 270 (AG-270; AG270) is a novel, first-in-class, reversible, allosteric, noncompetitiveand orally bioactiveMAT2Ainhibitor(IC50=14 nM) with anticancer activity.
V39070 FIDAS-5 1391934-98-7 FIDAS-5 is a novel and potent methionine S-adenosyltransferase 2A (MAT2A) inhibitor.
V2253 FIDAS-5 1391934-98-7 FIDAS-5 is a novel , potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor ( IC50 = 2.1 μM).
V10451 MAT2A inhibitor 2 13299-99-5 MAT2A inhibitor 2 HCl salt is a novel and potent inhibitor of methionine adenosyltransferase 2A (MAT2A) with potential anticancer activity.
V51811 MAT2A inhibitor 3 2439271-82-4
V51810 MAT2A inhibitor 4 1391934-91-0
V51812 MAT2A-IN-10 2924825-23-8
V79758 MAT2A-IN-11
V56101 MAT2A-IN-12 631897-75-1
V53126 MAT2A-IN-9 2439277-80-0
V3386 PF-9366 72882-78-1 PF-9366 (PF9366) is a novel, potent and allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A) with anticancer activity.
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