yingweiwo

MAT

MAT

Methionine adenosyltransferases (MATs), also referred to as S-Adenosylmethionine synthetases, are crucial for life because they catalyze the synthesis of S-adenosylmethionine, one of the most significant and pivotal biological molecules. The biological methyl donor necessary for a wide range of cell reactions is S-adenosylmethionine. The catalytic subunits of the MAT isoenzymes, MAT1 and MAT2, are encoded by two genes in mammalian systems, MAT1A and MAT2A, respectively. A third gene, MAT2B, produces the regulatory subunit MAT, which regulates the activity of MAT2 and is encoded by this gene. While MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal liver cells (such as hepatic stellate and Kupffer cells), MAT1A, which is primarily expressed in hepatocytes, maintains the differentiated state of these cells.

MAT related products

Structure Cat No. Product Name CAS No. Product Description
AG-270 V2489 AG-270 2201056-66-6 AG 270 (AG-270; AG270) is a novel, first-in-class, reversible, allosteric, noncompetitiveand orally bioactiveMAT2Ainhibitor(IC50=14 nM) with anticancer activity.
AZ'9567 V88900 AZ'9567 AZ9567 is a potent MAT2A inhibitor.
FIDAS-5 V2253 FIDAS-5 1391934-98-7 FIDAS-5 is a potent orally bioactive methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of 2.1 μM.
FIDAS-5 HCl V39070 FIDAS-5 HCl 1391934-98-7 FIDAS-5 HCl is a potent orally bioactive methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of 2.1 μM.
MAT2A inhibitor 2 V10451 MAT2A inhibitor 2 13299-99-5 MAT2A inhibitor 2 HCl salt is a novel and potent inhibitor of methionine adenosyltransferase 2A (MAT2A) with potential anticancer activity.
MAT2A inhibitor 3 V51811 MAT2A inhibitor 3 2439271-82-4 MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor (antagonist) with IC50 of <200 nM.
MAT2A inhibitor 4 V51810 MAT2A inhibitor 4 1391934-91-0 MAT2A inhibitor 4 is an inhibitor (blocker/antagonist) of methionine S-adenosyltransferase-2 catalytic subunit (MAT2A).
MAT2A inhibitor 5 V88901 MAT2A inhibitor 5 2957874-18-7 MAT2A inhibitor 5 (compound 39) is a blood-brain permeable, orally active and selective MAT2A inhibitor with an IC50 value of 11 nM.
MAT2A-IN-10 V51812 MAT2A-IN-10 2924825-23-8 MAT2A-IN-10 (Compound 28) is an orally bioactive MAT2A inhibitor (antagonist) with IC50 of 26 nM.
MAT2A-IN-11 V79758 MAT2A-IN-11 MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with IC50 of 6.8 nM.
MAT2A-IN-12 V56101 MAT2A-IN-12 631897-75-1 MAT2A Allosteric inhibitor 2 is a potent and specific allosteric inhibitor of MAT2A with IC50 of 5 nM.
MAT2A-IN-13 V85860 MAT2A-IN-13 2851449-24-4
MAT2A-IN-15 V88902 MAT2A-IN-15 MAT2A-IN-15 (compound 8) is an inhibitor of MAT2A.
MAT2A-IN-9 V53126 MAT2A-IN-9 2439277-80-0 MAT2A-IN-9 (compound 167) is a 2-oxoquinazoline analogue and a potent MAT2A (methionine adenosyltransferase 2A) inhibitor.
PF-9366 V3386 PF-9366 72882-78-1 PF-9366 (PF9366) is a novel, potent and allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A) with anticancer activity.
Contact Us