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STAT

STAT

The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.

STAT related products

Structure Cat No. Product Name CAS No. Product Description
(E/Z)-OSM-SMI-10B V87055 (E/Z)-OSM-SMI-10B 2502294-55-3 (E/Z)-OSM-SMI-10B is a derivative of OSM-SMI-10.
(R,R)-VVD-118313 V51515 (R,R)-VVD-118313 2875046-31-2 (R,R)-VVD-118313 is the seven bodies of VVD-118313.
15(R)-Lipoxin A4 V102604 15(R)-Lipoxin A4 171030-11-8 15(R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and lipid-derived lipoxin-type resolution mediator (SPM) that promotes the resolution of inflammation and regulates immune cell function.
5-FAM-GpYLPQTV-NH2 V85008 5-FAM-GpYLPQTV-NH2 769166-98-5
5-FAM-GpYLPQTV-NH2 TFA V87041 5-FAM-GpYLPQTV-NH2 TFA 5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide with STAT3 inhibitory activity.
Ac-GpYLPQTV-NH2 V85002 Ac-GpYLPQTV-NH2 1349616-70-1
Ac-GpYLPQTV-NH2 acetate V106122 Ac-GpYLPQTV-NH2 acetate Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with IC50 of 0.33 μM.
Anti-inflammatory agent 92 V101159 Anti-inflammatory agent 92 1609387-77-0 Anti-inflammatory agent 92 (compound LD4) is a porphyrin derivative.
Anticancer agent 259 V104473 Anticancer agent 259 Anticancer agent 259 (compound 3g) is a telmisartan-based cell death regulator that interferes with the STAT5 signaling pathway and enhances the sensitivity of resistant cells to imatinib, with a SC50 of 1.5 μM.
BML-260 V87064 BML-260 101439-76-3 BML-260 is a potent dual-specific phosphatase inhibitor of JSP-1 and DUSP22.
C188-9 V3113 C188-9 432001-19-9 C188-9 is a novel, potent and orally bioavailable STAT3 inhibitorthat binds to STAT3 with high affinity (KD=4.7±0.4 nM).
CDK8/19-IN-2 V87057 CDK8/19-IN-2 3024381-54-9 CDK8/19-IN-2 (compound 12) is an orally available inhibitor of cell cycle-dependent kinase 8/19 (CDK8 and CDK19) with IC50 values of 2.08 and 2.49 nM, respectively.
CYD0682 V88682 CYD0682 CYD0682 is an oridonin analog.
HJC0152 hydrochloride V2741 HJC0152 hydrochloride 1420290-99-8 HJC0152 hydrochloride is a novel, orally bioavailable and potentinhibitor of the signal transducers and activators of transcription 3(STAT3).
HO-3867 V1384 HO-3867 1172133-28-6 HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity.
Icotrokinra V100238 Icotrokinra 2763602-16-8 Icotrokinra (JNJ-77242113) is an oral, selective IL-23 receptor antagonist.
JAK1-IN-16 V104590 JAK1-IN-16 JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and can effectively downregulate TLR4 protein expression.
Methyllinderone V69150 Methyllinderone 3984-73-4 Methyllinderone is an inhibitor (blocker/antagonist) of AP-1/STAT/ERK.
phospho-STAT3-IN-2 V87059 phospho-STAT3-IN-2 Phospho-STAT3-IN-2 (compound 4D) is a STAT3 inhibitor that can effectively inhibit STAT3 phosphorylation.
Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) V69146 Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) 1794795-40-6 Pimozide-d5 N-Oxide is the deuterium labelled form of Pimozide.
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