The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V87055 | (E/Z)-OSM-SMI-10B | 2502294-55-3 | (E/Z)-OSM-SMI-10B is a derivative of OSM-SMI-10. |
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V51515 | (R,R)-VVD-118313 | 2875046-31-2 | (R,R)-VVD-118313 is the seven bodies of VVD-118313. |
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V102604 | 15(R)-Lipoxin A4 | 171030-11-8 | 15(R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and lipid-derived lipoxin-type resolution mediator (SPM) that promotes the resolution of inflammation and regulates immune cell function. |
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V85008 | 5-FAM-GpYLPQTV-NH2 | 769166-98-5 | |
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V87041 | 5-FAM-GpYLPQTV-NH2 TFA | 5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide with STAT3 inhibitory activity. | |
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V85002 | Ac-GpYLPQTV-NH2 | 1349616-70-1 | |
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V106122 | Ac-GpYLPQTV-NH2 acetate | Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with IC50 of 0.33 μM. | |
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V101159 | Anti-inflammatory agent 92 | 1609387-77-0 | Anti-inflammatory agent 92 (compound LD4) is a porphyrin derivative. |
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V104473 | Anticancer agent 259 | Anticancer agent 259 (compound 3g) is a telmisartan-based cell death regulator that interferes with the STAT5 signaling pathway and enhances the sensitivity of resistant cells to imatinib, with a SC50 of 1.5 μM. | |
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V87064 | BML-260 | 101439-76-3 | BML-260 is a potent dual-specific phosphatase inhibitor of JSP-1 and DUSP22. |
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V3113 | C188-9 | 432001-19-9 | C188-9 is a novel, potent and orally bioavailable STAT3 inhibitorthat binds to STAT3 with high affinity (KD=4.7±0.4 nM). |
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V87057 | CDK8/19-IN-2 | 3024381-54-9 | CDK8/19-IN-2 (compound 12) is an orally available inhibitor of cell cycle-dependent kinase 8/19 (CDK8 and CDK19) with IC50 values of 2.08 and 2.49 nM, respectively. |
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V88682 | CYD0682 | CYD0682 is an oridonin analog. | |
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V2741 | HJC0152 hydrochloride | 1420290-99-8 | HJC0152 hydrochloride is a novel, orally bioavailable and potentinhibitor of the signal transducers and activators of transcription 3(STAT3). |
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V1384 | HO-3867 | 1172133-28-6 | HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity. |
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V100238 | Icotrokinra | 2763602-16-8 | Icotrokinra (JNJ-77242113) is an oral, selective IL-23 receptor antagonist. |
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V104590 | JAK1-IN-16 | JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and can effectively downregulate TLR4 protein expression. | |
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V69150 | Methyllinderone | 3984-73-4 | Methyllinderone is an inhibitor (blocker/antagonist) of AP-1/STAT/ERK. |
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V87059 | phospho-STAT3-IN-2 | Phospho-STAT3-IN-2 (compound 4D) is a STAT3 inhibitor that can effectively inhibit STAT3 phosphorylation. | |
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V69146 | Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) | 1794795-40-6 | Pimozide-d5 N-Oxide is the deuterium labelled form of Pimozide. |