STAT

STAT

The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.

STAT related products

Structure Cat No. Product Name CAS No. Product Description
V51515 (R,R)-VVD-118313 2875046-31-2 (R,R)-VVD-118313 is the seven bodies of VVD-118313.
V85008 5-FAM-GpYLPQTV-NH2 769166-98-5
V85002 Ac-GpYLPQTV-NH2 1349616-70-1
V3113 C188-9 432001-19-9 C188-9 is a novel, potent and orally bioavailable STAT3 inhibitorthat binds to STAT3 with high affinity (KD=4.7±0.4 nM).
V1383 Cryptotanshinone (Cryptotanshinon) 35825-57-1 Cryptotanshinone (also called Cryptotanshinon; Tanshinone c), a naturally occuring compound found from the roots of Salvia miltiorrhiza Bunge (Danshen, a Chinesemedicinal plant), is a potent STAT3 inhibitor with potential antitumor activity.
V2741 HJC0152 hydrochloride 1420290-99-8 HJC0152 hydrochloride is a novel, orally bioavailable and potentinhibitor of the signal transducers and activators of transcription 3(STAT3).
V1384 HO-3867 1172133-28-6 HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity.
V69150 Methyllinderone 3984-73-4 Methyllinderone is an inhibitor (blocker/antagonist) of AP-1/STAT/ERK.
V1386 Napabucasin (BBI-608) 83280-65-3 Napabucasin (formerly also known as BBI-608; BBI608; BBI 608) is a novel, potent, and orally bioavailable cancer cell stemness inhibitor with potential antineoplastic activity.
V1382 Nifuroxazide 965-52-6 Nifuroxazide (Bacifurane; Diafuryl;Ambatrol; Antinal;Diarlidan) is a potent,cell-permeable and orally bioavailable nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
V69146 Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) 1794795-40-6 Pimozide-d5 N-Oxide is the deuterium labelled form of Pimozide.
V1378 S3I-201 (NSC 74859) 501919-59-1 S3I-201 (also called S3I201;NSC74859;S3I 201;NSC-74859) is a cell permeable and selective Stat3 inhibitor with potential anticancer activity.
V1385 SH-4-54 1456632-40-8 SH-4-54 (SH 454;SH4-54; SH454;SH-454) is anovel and potent STAT inhibitor with potential antineoplastic activity.
V86011 STAT3-IN-21, cell-permeable, negative control 400628-17-3
V51608 STAT3-IN-7 1313019-65-6 STAT3-IN-7 is a model of sorafenib that effectively inhibits STAT3 phosphorylation.
V1380 Stattic 19983-44-9 Stattic (6-Nitro-1-benzothiophene 1,1-dioxide) isa small molecule inhibitor of STAT3 that potently inhibits STAT3 activation and nuclear translocation with potential antineoplastic activity.
V79653 Syk-IN-6 Syk-IN-6 is an inhibitor (blocker/antagonist) of lipid-SH2 domain interactions and controls the cellular activity of SH2 domain-containing kinases.
V51536 W-1131 2740522-79-4 W1131 is a potent STAT3 activator that induces ferroptosis (ferroptosis).
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