The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51515 | (R,R)-VVD-118313 | 2875046-31-2 | (R,R)-VVD-118313 is the seven bodies of VVD-118313. |
|
V85008 | 5-FAM-GpYLPQTV-NH2 | 769166-98-5 | |
|
V85002 | Ac-GpYLPQTV-NH2 | 1349616-70-1 | |
|
V3113 | C188-9 | 432001-19-9 | C188-9 is a novel, potent and orally bioavailable STAT3 inhibitorthat binds to STAT3 with high affinity (KD=4.7±0.4 nM). |
|
V1383 | Cryptotanshinone (Cryptotanshinon) | 35825-57-1 | Cryptotanshinone (also called Cryptotanshinon; Tanshinone c), a naturally occuring compound found from the roots of Salvia miltiorrhiza Bunge (Danshen, a Chinesemedicinal plant), is a potent STAT3 inhibitor with potential antitumor activity. |
|
V2741 | HJC0152 hydrochloride | 1420290-99-8 | HJC0152 hydrochloride is a novel, orally bioavailable and potentinhibitor of the signal transducers and activators of transcription 3(STAT3). |
|
V1384 | HO-3867 | 1172133-28-6 | HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity. |
|
V69150 | Methyllinderone | 3984-73-4 | Methyllinderone is an inhibitor (blocker/antagonist) of AP-1/STAT/ERK. |
|
V1386 | Napabucasin (BBI-608) | 83280-65-3 | Napabucasin (formerly also known as BBI-608; BBI608; BBI 608) is a novel, potent, and orally bioavailable cancer cell stemness inhibitor with potential antineoplastic activity. |
|
V1382 | Nifuroxazide | 965-52-6 | Nifuroxazide (Bacifurane; Diafuryl;Ambatrol; Antinal;Diarlidan) is a potent,cell-permeable and orally bioavailable nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
|
V69146 | Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) | 1794795-40-6 | Pimozide-d5 N-Oxide is the deuterium labelled form of Pimozide. |
|
V1378 | S3I-201 (NSC 74859) | 501919-59-1 | S3I-201 (also called S3I201;NSC74859;S3I 201;NSC-74859) is a cell permeable and selective Stat3 inhibitor with potential anticancer activity. |
|
V1385 | SH-4-54 | 1456632-40-8 | SH-4-54 (SH 454;SH4-54; SH454;SH-454) is anovel and potent STAT inhibitor with potential antineoplastic activity. |
|
V86011 | STAT3-IN-21, cell-permeable, negative control | 400628-17-3 | |
|
V51608 | STAT3-IN-7 | 1313019-65-6 | STAT3-IN-7 is a model of sorafenib that effectively inhibits STAT3 phosphorylation. |
|
V1380 | Stattic | 19983-44-9 | Stattic (6-Nitro-1-benzothiophene 1,1-dioxide) isa small molecule inhibitor of STAT3 that potently inhibits STAT3 activation and nuclear translocation with potential antineoplastic activity. |
|
V79653 | Syk-IN-6 | Syk-IN-6 is an inhibitor (blocker/antagonist) of lipid-SH2 domain interactions and controls the cellular activity of SH2 domain-containing kinases. | |
|
V51536 | W-1131 | 2740522-79-4 | W1131 is a potent STAT3 activator that induces ferroptosis (ferroptosis). |
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