The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V87055 | (E/Z)-OSM-SMI-10B | 2502294-55-3 | (E/Z)-OSM-SMI-10B is a derivative of OSM-SMI-10. |
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V51515 | (R,R)-VVD-118313 | 2875046-31-2 | (R,R)-VVD-118313 is the seven bodies of VVD-118313. |
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V85008 | 5-FAM-GpYLPQTV-NH2 | 769166-98-5 | |
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V87041 | 5-FAM-GpYLPQTV-NH2 TFA | 5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide with STAT3 inhibitory activity. | |
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V85002 | Ac-GpYLPQTV-NH2 | 1349616-70-1 | |
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V101159 | Anti-inflammatory agent 92 | 1609387-77-0 | Anti-inflammatory agent 92 (compound LD4) is a porphyrin derivative. |
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V87064 | BML-260 | 101439-76-3 | BML-260 is a potent dual-specific phosphatase inhibitor of JSP-1 and DUSP22. |
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V3113 | C188-9 | 432001-19-9 | C188-9 is a novel, potent and orally bioavailable STAT3 inhibitorthat binds to STAT3 with high affinity (KD=4.7±0.4 nM). |
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V87057 | CDK8/19-IN-2 | 3024381-54-9 | CDK8/19-IN-2 (compound 12) is an orally available inhibitor of cell cycle-dependent kinase 8/19 (CDK8 and CDK19) with IC50 values of 2.08 and 2.49 nM, respectively. |
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V88682 | CYD0682 | CYD0682 is an oridonin analog. | |
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V2741 | HJC0152 hydrochloride | 1420290-99-8 | HJC0152 hydrochloride is a novel, orally bioavailable and potentinhibitor of the signal transducers and activators of transcription 3(STAT3). |
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V1384 | HO-3867 | 1172133-28-6 | HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity. |
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V100238 | Icotrokinra | 2763602-16-8 | Icotrokinra (JNJ-77242113) is an oral, selective IL-23 receptor antagonist. |
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V69150 | Methyllinderone | 3984-73-4 | Methyllinderone is an inhibitor (blocker/antagonist) of AP-1/STAT/ERK. |
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V87059 | phospho-STAT3-IN-2 | Phospho-STAT3-IN-2 (compound 4D) is a STAT3 inhibitor that can effectively inhibit STAT3 phosphorylation. | |
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V69146 | Pimozide-d5 N-Oxide (Pimozide d5 (N-oxide)) | 1794795-40-6 | Pimozide-d5 N-Oxide is the deuterium labelled form of Pimozide. |
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V98051 | PMMB-187 | 2162952-37-4 | PMMB-187 is a selective STAT3 inhibitor with IC50 of 1.81 μM in MDA-MB-231 cells. |
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V1378 | S3I-201 (NSC 74859) | 501919-59-1 | S3I-201 (also called S3I201;NSC74859;S3I 201;NSC-74859) is a cell permeable and selective Stat3 inhibitor with potential anticancer activity. |
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V1385 | SH-4-54 | 1456632-40-8 | SH-4-54 (SH 454;SH4-54; SH454;SH-454) is anovel and potent STAT inhibitor with potential antineoplastic activity. |
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V87048 | Smad2/3-IN-1 | Smad2/3-IN-2 (Compound 3) is an inhibitor of TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathways with IC50 of 90 nM and 20 nM, respectively. |