Chloride channels are part of a superfamily of ion channels that allow anions, primarily chloride, to passively pass through cell membranes. The control of cellular excitability, transepithelial transport, cell volume regulation, and acidification of intracellular organelles are all important functions of chloride channels. One class of potential drug targets is chloride channels.
Both chloride (Cl-) channels and chloride/proton (Cl-/H+) antiporters are members of the chloride channel protein (ClC) family. These proteins mediate the movement of Cl- ions across the membrane in prokaryotes and eukaryotes. The stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity, and vesicular acidification are all functions of ClC proteins in eukaryotes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V6624 | Ani9 | 356102-14-2 | Ani9 is a potent and specific blocker of transmembrane protein 16A (TMEM16A, Anoctamin-1) with IC50 of 77 nM. |
|
V74261 | Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) | 723-62-6 | Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene analogue traditionally used to block and recognize Ca2+-activated Cl in various cell types, such as various smooth muscle cells, epithelial cells, and salivary gland cells. |
|
V74265 | Anthracene-9-carboxylic acid-d9 (9-Anthracenecarboxylic acid-d9) | 1219803-78-7 | Anthracene-9-carboxylic acid-d9 is the deuterated form of Anthracene-9-carboxylic acid. |
|
V84877 | ARN11391 | 1214569-31-9 | |
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V2866 | CaCCinh-A01 | 407587-33-1 | CaCCinh-A01 (also known as TMEM16 Blocker I) is an inhibitor of TMEM16Aandcalcium-activated chloride channel(CaCC) withIC50s of 2.1 and 10 μM, respectively. |
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V77152 | Chlorotoxin TFA (chlorotoxin TFA salt) | Chlorotoxin TFA is a bioactive peptide extracted from scorpion venom and is a chloride channel blocker. | |
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V74266 | DFBTA | 2966044-07-3 | DFBTA is an orally bioactive, low-brain-penetrating ANO1 (calcium-activated chloride channel) inhibitor (antagonist) with IC50 of 24 nM. |
|
V74262 | Fenamic acid (fenamic acid; N-Phenylanthranilic acid) | 91-40-7 | Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally bioactive chloride channel blocker. |
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V74260 | GaTx2 | 194665-85-5 | GaTx2 is a selective, high-affinity inhibitor of ClC-2 channels with an apparent KD voltage dependence of ~20 pM. |
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V74264 | Lubiprostone-d7 (RU-0211-d7; SPI-0211-d7) | 1217675-13-2 | Lubiprostone-d7 is the deuterium labelled form of Lubiprostone. |
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V74267 | MONNA | 1572936-83-4 | MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with IC50 of 80 nM. |
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V74263 | Niflumic Acid-d5 (niflumic acid d5) | 1794811-58-7 | Niflumic Acid-d5 is the deuterated form of Niflumic acid. |
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V87143 | NMD670 | 2354321-33-6 | NMD670 is a partial inhibitor of the skeletal muscle-specific chloride channel ClC-1 and is orally active. |
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V3319 | NS1652 | 1566-81-0 | NS1652 is a novel, reversibleanion conductanceinhibitor which blockschloride channelwith anIC50of 1.6 μM in human and mouse red blood cells. |
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V74268 | Phenyl benzoate | 93-99-2 | Phenyl benzoate, obtained by the condensation of phenol and benzoic acid, is a chloride ion transport blocker that can inhibit Cl-dependent Glu accumulation in vesicles. |
|
V14729 | Shikonin (C.I.-75535; Isoarnebin 4) | 517-89-5 | Shikonin (C. |
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V5120 | T16Ainh-A01 | 552309-42-9 | T16Ainh-A01 is an aminophenylthiazole analog acting as a novel and potent transmembrane protein 16A (TMEM16A) inhibitor which inhibits TMEM16A-mediated chloride currents with an IC50value of ~1 µM. |
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V8865 | Talniflumate (BA 7602-06) | 66898-62-2 | Talniflumate(BA -602-06), a prodrug of Niflumic acid, is a potent,orally bioactive and selective inhibitor of core mucin-synthesizing enzyme GCNT3 (core 2b-1,6 N-acetylglucosaminyltrans-ferase). |
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