The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51555 | (E)-Osmundacetone | 123694-03-1 | neuroprotective agent |
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V69324 | (R)-Afatinib ((R)-BIBW 2992) | 439081-17-1 | (R)-Afatinib ((R)-BIBW 2992) is an isomer of Afatinib. |
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V67534 | 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine | 2226941-29-1 | 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is a protein kinase inhibitor (antagonist) with IC50 of PKC-α, ROCK, and ASK1. |
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V2863 | Acumapimod (BCT-197) | 836683-15-9 | Acumapimod (also known as BCT197) is a potent and orally bioavailable small molecule inhibitor of the p38 MAP kinase (MAPK-mitogen-activated protein kinase) with an IC50 of less than 1 μM for p38α. |
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V3639 | Adezmapimod (SB-203580) hydrochloride | 869185-85-3 | Adezmapimod hydrochloride (formerly SB-203580 HCl; SB203580;RWJ-64809; RWJ64809)is a p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with IC50 of 0.3-0.5 μM in THP-1 cells, it is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. |
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V0476 | Adezmapimod (SB203580; RWJ-64809) | 152121-47-6 | Adezmapimod (SB-203580; RWJ-64809; SB203580; RWJ64809) is a novel and potent p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with the potential to treat Systemic lupus erythematosus (SLE). |
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V25155 | AMG 548 dihydrochloride | 864249-60-5 | AMG-548 dihydrochloride is a novel, orally bioactive, potent and selective inhibitor of p38α with Ki of 0.5 nM. |
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V60109 | Andrograpanin | 82209-74-3 | Andrograpanin is a bioactive compound from Andrographis paniculata that has anti~inflammatory and anti-infection properties. |
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V74117 | Anti-inflammatory agent 33 | 2816993-09-4 | Anti-inflammatory agent 33 is a potent inhibitor of p38α. |
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V0488 | Asiatic Acid (Dammarolic acid, Asiantic acid) | 464-92-6 | Asiatic acid (Dammarolic acid, Asiantic acid) is a naturally occuring pentacyclic triterpene and aglycone of asiaticoside isolated from a variety of plants, including the plant C. |
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V74103 | ASK1-IN-1 | 2411382-24-4 | ASK1-IN-1 is a CNS-penetrant apoptosis signal-regulated kinase 1 (ASK1) inhibitor (antagonist) with good potency (cellular IC50=138 nM; Biochemical IC50=21 nM). |
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V67600 | Atraric acid (Methyl atrarate) | 4707-47-5 | Atraric acid (Methyl atrarate) is a specific androgen receptor antagonist (inhibitor) with anti-inflammatory and anti-cancer effects. |
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V4240 | AZD7624 | 1095004-78-6 | AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity. |
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V0477 | BIRB 796 (Doramapimod) | 285983-48-4 | BIRB 796 (also known as doramapimod) is a novel, orally bioactive, and highly potentpan-p38 MAPK inhibitor with potential anti-inflammatory activity. |
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V2686 | BMS-582949 | 623152-17-0 | BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM. |
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V2668 | BMS-582949 HCl | 912806-16-7 | BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM. |
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V74102 | BSJ-04-122 | 2513289-74-0 | BSJ-04-122 is a covalent MKK4/7 dual (bifunctional) inhibitor. |
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V74120 | Cannabisin D | 144506-19-4 | Cannabisin D inhibits glioblastoma cell growth/proliferation and migration through MAPK signaling. |
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V33266 | Cornuside | 131189-57-6 | Cornuside is an iridoid glycoside extracted from the fruit of Cornus officinalis Sieb. |
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V74106 | Cyclocurcumin | 153127-42-5 | Cyclocurcumin is a potent inhibitor of p38α. |
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