p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.

The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.

p38 MAPK related products

Structure Cat No. Product Name CAS No. Product Description
V51555 (E)-Osmundacetone 123694-03-1 neuroprotective agent
V69324 (R)-Afatinib ((R)-BIBW 2992) 439081-17-1
V67534 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 2226941-29-1
V2863 Acumapimod (BCT-197) 836683-15-9 Acumapimod (also known as BCT197) is a potent and orally bioavailable small molecule inhibitor of the p38 MAP kinase (MAPK-mitogen-activated protein kinase) with an IC50 of less than 1 μM for p38α.
V3639 Adezmapimod (SB-203580) hydrochloride 869185-85-3 Adezmapimod hydrochloride (formerly SB-203580 HCl; SB203580;RWJ-64809; RWJ64809)is a p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with IC50 of 0.3-0.5 μM in THP-1 cells, it is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.
V0476 Adezmapimod (SB203580; RWJ-64809) 152121-47-6 Adezmapimod (SB-203580; RWJ-64809; SB203580; RWJ64809) is a novel and potent p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with the potential to treat Systemic lupus erythematosus (SLE).
V25155 AMG 548 dihydrochloride 864249-60-5 AMG-548 dihydrochloride is a novel, orally bioactive, potent and selective inhibitor of p38α with Ki of 0.5 nM.
V60109 Andrograpanin 82209-74-3
V74117 Anti-inflammatory agent 33 2816993-09-4
V0488 Asiatic Acid (Dammarolic acid, Asiantic acid) 464-92-6 Asiatic acid (Dammarolic acid, Asiantic acid) is a naturally occuring pentacyclic triterpene and aglycone of asiaticoside isolated from a variety of plants, including the plant C.
V74103 ASK1-IN-1 2411382-24-4
V67600 Atraric acid (Methyl atrarate) 4707-47-5
V4240 AZD7624 1095004-78-6 AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity.
V0477 BIRB 796 (Doramapimod) 285983-48-4 BIRB 796 (also known as doramapimod) is a novel, orally bioactive, and highly potentpan-p38 MAPK inhibitor with potential anti-inflammatory activity.
V2686 BMS-582949 623152-17-0 BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.
V2668 BMS-582949 HCl 912806-16-7 BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.
V74102 BSJ-04-122 2513289-74-0
V74120 Cannabisin D 144506-19-4
V33266 Cornuside 131189-57-6 Cornuside is a novel and potent secoiridoid glucoside.
V74106 Cyclocurcumin 153127-42-5
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