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Protein Arginine Deiminase

Protein Arginine Deiminase

A family of calcium-dependent enzymes known as Protein Arginine Deiminase (PAD) is able to catalyze the conversion of arginine residues into citrulline. Numerous pathological diseases, including inflammation and autoimmune disorders, are caused by this chemical reaction, which also causes the formation of citrullinated proteins with altered structure and function. These pathologies made the PADs viable therapeutic targets, and several PAD inhibitors are currently available.
Five PADs, known as PADs 1-4 and PAD6, are encoded by humans. Only four (PADs1-4) of the five PAD isozymes (PADs1, 2, 3, 4, and 6) are catalytically active. Ca2+ is a key regulator of PAD activity, and PADs have 4 (PAD1), 5 (PAD3), or 6 (PAD2) Ca2+-binding sites. Multiple inflammatory diseases (like rheumatoid arthritis) and cancer are linked to dysregulated PAD activity, and PAD inhibitors like Cl-amidine and BB-Cl-amidine are effective in a variety of preclinical animal disease models.

Protein Arginine Deiminase related products

Structure Cat No. Product Name CAS No. Product Description
AFM-30a V52435 AFM-30a 2095107-57-4 AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor (antagonist) with excellent PAD2 selectivity.
AFM-30a hydrochloride V77281 AFM-30a hydrochloride AFM-30a HCl is a potent protein arginine deiminase 2 (PAD2) inhibitor (antagonist) with excellent PAD2 selectivity.
AFM32a (PAD2-IN-1) V22824 AFM32a (PAD2-IN-1) 2095109-82-1 AFM32a (PAD2-IN-1), a benzimidazole-based analogue, is a potent and specific inhibitor of protein arginine deiminase 2 (PAD2).
AFM32a hydrochloride (PAD2-IN-1 hydrochloride) V77280 AFM32a hydrochloride (PAD2-IN-1 hydrochloride) 2988594-85-8 AFM32a (PAD2-IN-1) HCl, a benzimidazole-based analogue, is a potent and specific inhibitor of protein arginine deiminase 2 (PAD2).
BB-Cl-Amidine V32207 BB-Cl-Amidine 1802637-39-3 BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor with potentialfor Canine and Feline Mammary Cancer via Activation of the Endoplasmic Reticulum Stress Pathway.
BB-Cl-Amidine hydrochloride V53041 BB-Cl-Amidine hydrochloride 2436747-41-8 BB-Cl-Amidine HCl is an inhibitor (blocker/antagonist) of peptidyl arginine deaminase (PAD).
BB-Cl-Yne V94556 BB-Cl-Yne 2219324-71-5 BB-Cl-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of 6400, 3600, 10800, and 4900 M-1min-1 for PAD1-4, respectively.
BB-F-Yne V94580 BB-F-Yne 2219331-30-1 BB-F-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of 2050, 1700, 1100, and 3100 M-1min-1 for PAD1-4, respectively.
BMS-P5 HCL V60078 BMS-P5 HCL 1549811-36-0 BMS-P5 is a specific, orally bioactive inhibitor of peptide arginine diiminase 4 (PAD4).
Cl-amidine V28803 Cl-amidine 913723-61-2 Cl-amidine is an orally bioavailable PAD inhibitor (antagonist) with IC50s of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4 respectively.
D-Cl-amidine hydrochloride V77100 D-Cl-amidine hydrochloride 2985338-61-0 D-Cl-amidine HCl is a potent and selective PAD1 inhibitor.
F-Amidine TFA V88919 F-Amidine TFA 877617-46-4 F-Amidine TFA is a protein arginine deiminase 4 (PAD4) inhibitor that can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis).
GSK199 analog hydrochloride V88920 GSK199 analog hydrochloride 2048226-46-4 GSK199 analog hydrochloride belongs to a class of compounds that inhibit PAD4 (guanidinoarginine deiminase 4).
GSK484盐酸盐 V3606 GSK484 HCl 1652591-81-5 GSK484 HCl is a novel and potent inhibitor of peptidylarginine deiminase 4 (PAD4).
JBI-589 V51674 JBI-589 2308504-22-3 JBI-589 is a non-covalent, selective PAD4 inhibitor.
KP-302 V88921 KP-302 2082765-42-0 KP-302 (compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM.
PAD4-IN-2 V56116 PAD4-IN-2 2642327-52-2 PAD4-IN-2 (Compound 5i) is a PAD4 inhibitor (IC50=1.94 μM).
PAD4-IN-2 TFA V88917 PAD4-IN-2 TFA PAD4-IN-2 (Compound 5i) TFA is a PAD4 inhibitor (IC50=1.94 μM).
PAD4-IN-3 V75474 PAD4-IN-3 2642327-44-2 PAD4-IN-3 (compound 4B) is a PAD4 inhibitor (antagonist) with anti-tumor activity in vitro and in vivo.
PAD4-IN-4 V88918 PAD4-IN-4 PAD4-IN-4 (compound 28) is a potent PAD4 inhibitor (IC50=0.79±0.09 μM).
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