A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3460 | AMG 232 | 1352066-68-2 | AMG 232 (AMG-232; AMG232) is a novel, potent, selective, orally bioavailable and piperidinone-based inhibitor of MDM2-p53 protein-protein interaction with anticancer activity. |
|
V73099 | Antitumor agent-81 | 2765180-17-2 | Antitumor agent-81 (compound 5 a) is a low cytotoxic P62-RNF168 agonist that promotes the interaction between P62 and RNF168. |
|
V73094 | BC-1382 | 1013753-99-5 | BC-1382 is a potent inhibitor of ubiquitin E3 ligase HECTD2 that specifically disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM). |
|
V73090 | Brigimadlin (BI 907828) | 2095116-40-6 | Brigimadlin (BI 907828) is an inhibitor (blocker/antagonist) of the E3 ubiquitin protein ligase MDM-2. |
|
V73102 | Cbl-b-IN-10 | 2815225-12-6 | Cbl-b-IN-10 (Compound 463) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 6.0 nM and 3.5 nM respectively. |
|
V73114 | Cbl-b-IN-11 | 2815225-15-9 | Cbl-b-IN-11 (Compound 466) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl with IC50 of 6.4 nM and 6.1 nM respectively. |
|
V73110 | Cbl-b-IN-12 | 2851871-29-7 | Cbl-b-IN-12 (Example 10) is a casitas b-lineage lymphoma (CBL-B) inhibitor (antagonist) with IC50 of <100 nM. |
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V73107 | Cbl-b-IN-13 | 2368841-85-2 | Cbl-b-IN-13 (Example 520) is a Cbl-b inhibitor (antagonist) with IC50 of <100 nM. |
|
V78678 | Cbl-b-IN-15 | Cbl-b-IN-15 (compound 25) is an inhibitor (blocker/antagonist) of the RING finger E3 ligase Cbl (IC50= 15 nM). | |
|
V73103 | Cbl-b-IN-6 | 2815221-33-9 | Cbl-b-IN-6 (Compound 246) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 5.8 nM and 4.4 nM respectively. |
|
V73104 | Cbl-b-IN-7 | 2815221-35-1 | Cbl-b-IN-7 (Compound 248) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 6.7 nM and 5.2 nM respectively. |
|
V73101 | Cbl-b-IN-8 | 2815223-33-5 | Cbl-b-IN-8 (Compound 293) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 5.5 nM and 7.8 nM respectively. |
|
V73113 | Cbl-b-IN-9 | 2815223-41-5 | Cbl-b-IN-9 (Compound 300) is an inhibitor (blocker/antagonist) of casitas b-lineage lymphoma (Cbl-b) and c-Cbl with IC50 of 5.6 nM and 4.7 nM respectively. |
|
V73112 | DCN1-UBC12-IN-2 | 2374827-47-9 | DCN1-UBC12-IN-2 is a potent and specific inhibitor of DCN1-UBC12 (IC50= 9.55 nM). |
|
V73106 | DI-404 | 2187412-79-7 | DI-404 is a potent inhibitor of DCN1 with a Kd of 6.7 nM. |
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V73086 | DI-591 | 2245887-38-9 | DI-591 is a potent, high-affinity and cell-permeable (penetrable) inhibitor of DCN1-UBC12 interaction. |
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V73105 | EN219 | 380351-29-1 | EN219 is a synthetic covalent ligand with moderate specificity for the N-terminal cysteine C8 of RNF114, with IC50 of 470 nM. |
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V73088 | HB007 | 2387821-46-5 | HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. |
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V73097 | HECT E3-IN-1 | 1810058-52-6 | HECT E3-IN-1 (compound 3) is an inhibitor (blocker/antagonist) of HECT E3 ligase. |
|
V76922 | HOIPIN-8 | HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with IC50 of 11 nM. |
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