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Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.

Ras related products

Structure Cat No. Product Name CAS No. Product Description
(S)-CCG-1423 V62605 (S)-CCG-1423 2319939-24-5 (S)-CCG-1423 is an inhibitor (blocker/antagonist) of Rho signaling and blocks the nuclear import of MRTF-A.
8-CPT-2Me-cAMP sodium V74717 8-CPT-2Me-cAMP sodium 634207-53-7 8-CPT-2Me-cAMP sodium is a selective agonist of exchange proteins activated by cAMP (Epac), a cAMP-sensitive guanine nucleotide exchange factor (GEF) of the small GTPases Rap1 and Rap2.
APS6-45 V74720 APS6-45 2188236-41-9 APS6-45 is an orally bioactive tumor calibration inhibitor (TCI).
ARS-1323 V4764 ARS-1323 1698024-73-5 ARS-1323 (ARS1323) is the racemic mixture of ARS-1620, which is a novel and potent inhibitor of mutant K-ras G12C with anticancer activity.
ARS-1620 V3974 ARS-1620 1698055-85-4 ARS-1620 is a novel, potent, orally bioavailable and covalent inhibitor ofKRASG12C with antitumor activity.
ARS-1630 V32351 ARS-1630 1698055-86-5 ARS-1630 is a less active isomer of ARS-1620, which is a novel and potent inhibitor of mutant K-ras G12C found in patent WO 2015054572 A1.
BAY-293 V4185 BAY-293 2244904-70-7 BAY-293 (BAY293) is a novel, potent, cell-active small-molecule SOS1 inhibitor with anticancer activity.
BI-2493 V74704 BI-2493 2937344-16-4 BI-2493 is a structural analog of BI-2865 and a selective pan-KRAS inhibitor.
BI-3406 (SOS1-IN-2) V31508 BI-3406 (SOS1-IN-2) 2230836-55-0 BI-3406 (BI3406; SOS1-IN-2) is a novel, orally bioactive, and selective inhibitor of Son of Sevenless 1 (SOS1) with anticancer activity.
CCG-203971 V3118 CCG-203971 1443437-74-8 CCG-203971 is a novel, 2nd generation small-molecule inhibitor of the Rho/MRTF/SRF [RhoA/myocardin-related transcription factor A (MRTF-A)] pathway with an IC50 value of 0.64 μM for SRE.
CID 44216842 V2441 CID 44216842 1222513-26-9 CID44216842 (Cdc42-IN-1) is a potent and specific Cdc42 inhibitor.
G12Si-1 V74707 G12Si-1 2946593-42-4 G12Si-1 is a selective covalent inhibitor of K-Ras(G12S) that can inhibit the transmission of K-Ras(G12S) oncogenic signals.
G12Si-2 V74726 G12Si-2 2946593-43-5 G12Si-2, an analog of G12Si-1, serves as a negative control (NC).
GGTI-286 V74723 GGTI-286 171744-11-9 GGTI-286 is a potent cell-permeable (penetrable) GGTase I inhibitor (IC50 is 2 μM).
GGTI-298 free base V12042 GGTI-298 free base 180977-44-0 GGTI-298 (GGTI298) is a potent geranylgeranyltransferase-I (GGTase-I) inhibitor with potential anticancer actrivity.
Glecirasib (JAB-21822; KRAS G12C inhibitor 36) V74733 Glecirasib (JAB-21822; KRAS G12C inhibitor 36) 2657613-87-9 Glecirasib (KRAS G12C inhibitor 36) is a potent KRAS G12C inhibitor.
ISIS 2503 V74730 ISIS 2503 149957-14-2 ISIS-2503 is an antisense oligonucleotide that can inhibit Ha-Ras expression.
K-Ras 抑制剂6 V2420 K-Ras inhibitor 6 2060530-16-5 K-Ras (G12C) inhibitor 6 is a novel, potent, allosteric, irreversible,/covalent cysteine-reactive small molecule KRAS G12C inhibitor with anticancer activity.
K-Ras-IN-1 V2944 K-Ras-IN-1 84783-01-7 K-Ras-IN-1 (formerly known as K-Ras-Inhibitor-1) is a novel small molecule K-Ras inhibitor that binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure, in other words, K-Ras-IN-1 binds directly to K-Ras between switch I and switch II and inhibit Sos-catalyzed K-Ras activation.
K-Ras-IN-2 V74735 K-Ras-IN-2 905794-70-9 K-Ras-IN-2 (Compound CHI-000-667) is a K-Ras antagonist that may be utilized in tumor-related research.
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