Acetyl-CoA Carboxylase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis.Acetyl-CoA carboxylase is a desirable target for the development of drugs to treat diabetes, cancer, and other diseases because of its critical roles in fatty acid metabolism.

Animals have two main ACC isoforms, ACC1 and ACC2, which are each encoded by a different gene and have different distributions in different tissues and cells. ACC, which is mediated by the related enzymes ACC1 and ACC2, catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA as the first committed step of fatty acid synthesis (FASyn). While ACC2 is attached to the mitochondrial outer membrane, where localized malonyl-CoA production inhibits carnitine palmitoyltransferase-1 (CPT-1) function to stop fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn), ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn.

Acetyl-CoA Carboxylase related products

Cat No.	Product Name	CAS No.	Product Description
V3018	TOFA (Olumacostat)	54857-86-2	TOFA (5‑tetradecyloxy‑2‑furoic acid), also known as RMI14514 and MDL14514, is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
V2050	CP640186	591778-68-6	CP-640186 is a novel, potent and and cell-permeableinhibitor of mammalian ACCs (isozyme-nonselective acetyl-CoA carboxylase) with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; It hash improved metabolic stability in comparison to CP-610431, an analog of CP-640186.
V2798	Firsocostat (ND-630; GS-0976; NDI-010976)	1434635-54-7	Firsocostat (formerly also known as ND-630; GS-0976; NDI-010976; ND630) is a novel and potent inhibitor of ACC (acetyl-CoA carboxylase) with IC50 values of 2.1 and 6.1 nM for human ACC1 and ACC2, respectively.
V26327	ND-646	1434639-57-2	ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.
V4450	PF-05175157	1301214-47-0	PF-05175157 (PF05175157) is a novel, potent and selective broad spectruminhibitor of acetyl-CoA carboxylase(ACC) with anti-diabetic and anticancer activity.