HIF HIF Prolyl-Hydroxylase

HIF HIF Prolyl-Hydroxylase

HIFs (Hypoxia-inducible factors) are transcription factors that react to variations in the amount of oxygen available to cells, more specifically, to reductions in oxygen, or hypoxia. The effects of hypoxia, a condition of low oxygen concentration, on the cell are mediated by the HIF signaling cascade. Oftentimes, hypoxia prevents cells from differentiating. However, hypoxia encourages the growth of blood vessels and is crucial for the development of a vascular system in both cancer tumors and embryos.Additionally, the hypoxia in wounds encourages keratinocyte migration and epithelium repair. HIFs are essential to development in general. HIF-1 gene deletion in mammals causes perinatal death. It has been demonstrated that HIF-1 is essential for chondrocyte survival and enables the cells to adapt to low oxygen environments in the growth plates of bones. Human metabolism is controlled in large part by HIF. A number of medications that function as selective HIF prolyl hydroxylase inhibitors have recently been created.

HIF HIF Prolyl-Hydroxylase related products

Structure Cat No. Product Name CAS No. Product Description
V73834 (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin) 5162-01-6 (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin.
V3952 1,4-DPCA 331830-20-7 1,4-DPCA is a novel, potent and competitive inhibitor of prolyl 4-hydroxylase with IC50 value of 3.6 μM.
V51644 1,4-DPCA ethyl ester 86443-19-8 1,4-DPCA ethyl ester is the ethyl ester form of 1,4-DPCA and can inhibit FIH.
V85084 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG 1613308-63-6
V51627 7-Hydroxyneolamellarin A 959662-26-1 7-Hydroxyneolamellarin A is a naturally occurring compound that can be found in the sponge Dendrilla nigra.
V51637 Acriflavine hydrochloride 69235-50-3 Acriflavine saltloride is a highly efficient fluorescent acridine dye that can be used for labeling.
V10310 Adaptaquin 385786-48-1 Adaptaquin is a novel and potent hydroxyquinoline inhibitor of HIF-PHD (hypoxia-inducible factor prolyl hydroxylase 2) with an IC50 of 2 μM.
V86307 AFP464 dihydrochloride (NSC710464 dihydrochloride)
V1909 Amifostine trihydrate (WR2721) 112901-68-5 Amifostine trihydrate (WR2721), a phosphorylated aminosulfhydryl compound, is the first approved radioprotective drug,it is used to decrease the risk of kidney problems caused by treatment with cisplatin.
V51635 Angiogenesis agent 1 2765218-28-6 Angiogenic agent 1 (compound C-31) is a glycoside analog of a Rhodiola rosean analogue.
V86107 Arylsulfonamide 64B (HIF inhibitor 64B) 1342890-83-8
V78298 Axl-IN-16 Axl-IN-16 is a dual (bifunctional) inhibitor of Axl and HIF.
V32376 Belzutifan (PT2977; MK-6482) 1672668-24-4 Belzutifan (PT-2977; MK-6482; PT2977; MK6482;Welireg)is a novel, selective and orally bioavailable HIF-2α (hypoxia-inducible factor 2α) inhibitor that has gained FDA approval in 2021 forthe treatment of von Hippel–Lindau disease-associated renal cell carcinoma.
V5194 Chlorogenic Acid (Heriguard; NSC-407296) 327-97-9 Chlorogenic acid (3-O-Caffeoylquinic acid; Heriguard; NSC-407296) is a naturally occuring phenolic compound found in coffee and tea.
V2834 Daprodustat (GSK1278863) 960539-70-2 Daprodustat (formerly known as GSK1278863; Duvroq) is a novel orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PHI)inhibitor that has been approved for treatment of anemia associated with CKD/chronic kidney disease.
V51630 Dimethyl-bisphenol A 1568-83-8 Dimethyl-bisphenol A (DMBPA) is a potent HIF-1α inhibitor.
V3443 EL102 1233948-61-2 EL102,a novel toluidine sulphonamide, is a novel inhibitor of HIF1α (hypoxia inducible factor) and can also potently inhibit tubulin polymerisation and decreased microtubule stability.
V20522 Enarodustat (JTZ951) 1262132-81-9 Enarodustat (formerly JTZ-951; JTZ951;Enaroy) is an orally bioactive hypoxia inducible factor-proly hydroxylase (HIF-PH) inhibitorapproved (in 2020) in Japan for the treatment of anemia associated with chronic kidney disease (CKD).
V79383 FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 is a 5-FAM-labeled HIF-1α peptide and a substrate of VHL.
V51626 Fenbendazole-d3 1228182-47-5 Fenbendazole-d3 is a cadmium-labeled fenbendazole.
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