The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52838 | (E/Z)-GO289 | 694522-87-7 | (E/Z)-GO289 is a potent and specific inhibitor of casein kinase 2 (CK2) (IC50=7 nM). |
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V55064 | Ac-ESMD-CHO | 191338-87-1 | Ac-ESMD-CHO is an inhibitor (blocker/antagonist) of caspase-3 and caspase-7. |
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V55062 | Ac-VDVAD-CHO | 194022-51-0 | Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50= 46 and 15 nM). |
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V52425 | AMG-548 dihydrochloride | 2518299-32-4 | AMG-548 di-HCl is an orally bioactive, selective p38α inhibitor (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ. |
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V52424 | AMG-548 hydrochloride | 2437438-16-7 | AMG-548 HCl is an orally bioactive, selective p38α inhibitor (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ. |
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V52313 | BTX161 | 2052301-24-1 | BTX161, a Thalidomide analogue, is a potent CKIα degrader. |
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V69794 | Casein kinase 1δ-IN-1 | 851871-94-8 | Casein kinase 1δ-IN-1 (compound 822) is an inhibitor (blocker/antagonist) of casein kinase 1δ (CK1δ) with an inhibitory effect of greater than 5%. |
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V69793 | Casein kinase 1δ-IN-10 | 332074-85-8 | Casein kinase 1δ-IN-10 is a casein kinase 1δ (CK1δ) inhibitor (WO2012080729A2; compound 685). |
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V69789 | Casein kinase 1δ-IN-14 | 793722-88-0 | Casein kinase 1δ-IN-14 (compound 481) is a casein kinase inhibitor that may be utilized to study neurodegenerative diseases such as AD/Alzheimer's disease. |
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V69792 | Casein kinase 1δ-IN-3 | 349438-77-3 | Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1δ (CK1d) inhibitor (antagonist) with pIC50 of 6.5376 M. |
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V69791 | Casein kinase 1δ-IN-4 | 851168-98-4 | Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ. |
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V69795 | Casein kinase 1δ-IN-5 | 1579991-10-8 | Casein kinase 1δ-IN-5 is a potent and specific inhibitor of protein kinase CK-1δ with IC50 of 47 nM. |
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V69785 | Casein kinase 1δ-IN-6 | 1579991-01-7 | Casein kinase 1δ-IN-6 is a potent and specific inhibitor of protein kinase CK-1δ with IC50 of 23 nM. |
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V69790 | Casein kinase 1δ-IN-7 | 764694-25-9 | Casein kinase 1δ-IN-7 (compound 497) is a Casein kinase 1δ inhibitor that may be utilized in the study of neurodegenerative diseases such as AD/Alzheimer's disease. |
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V69787 | Casein kinase 1δ-IN-8 | 851396-73-1 | Casein kinase 1δ-IN-8 (compound 494) is an inhibitor (blocker/antagonist) of casein kinase 1δ, which may be utilized to treat neurodegenerative diseases such as AD/Alzheimer's disease. |
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V69797 | Casein kinase 1δ-IN-9 | 854355-54-7 | Casein kinase 1δ-IN-9 (compound 737) is a potent inhibitor of casein kinase 1δ (CK1δ/CK15). |
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V55054 | Casein Kinase 2 Substrate Peptide | 132176-35-3 | Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. |
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V30019 | Casein Kinase II Inhibitor IV hydrochloride | 2320347-54-2 | Casein Kinase II Inhibitor IV HCl is a small molecule inducer of epidermal keratinocyte differentiation. |
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V55061 | Casein Kinase II Receptor Peptide | 198481-81-1 | Casein Kinase II Receptor Peptid is a substrate for Casein Kinase II with a Km of 500 µM. |
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V55056 | Casein Kinase II Substrate | 95651-74-4 | Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that is selectively phosphorylated by CK2. |
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