Sirtuin (Sir2 proteins) are a group of proteins that have deacylase activity, such as deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0436 | AGK2 | 304896-28-4 | AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity. |
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V6633 | AK-1 | 330461-64-8 | AK-1 is a potent, specific and cell-penetrating/penetrable SIRT2 inhibitor (antagonist) with IC50 of 12.5 μM. |
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V4086 | AK-7 | 420831-40-9 | AK-7 (also known as AK7, CS-3223 and GL-8955) is a novel, selective, cell- and brain-permeable SITR2 inhibitor with the potential to be used for the treatment of Parkinsons disease and Huntingtons disease (HD). |
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V3226 | Cambinol | 14513-15-6 | Cambinol (formerly NSC-112546) is a potent SIRT (silent information regulator enzymes) inhibitor withIC50values of 56 and 59 μM for SIRT1andSIRT2, respectively. |
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V2111 | CAY10602 | 374922-43-7 | CAY10602 (CAY-10602) is a novel and potentSIRT1activator. |
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V78969 | CypD-IN-4 | 3023438-19-6 | CypD-IN-4 is a potent isoform-selective cyclophilin D (CypD) inhibitor. |
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V78970 | CypE-IN-1 | 3023438-33-4 | CypD-IN-1 is a potent isoform-selective inhibitor of cyclophilin E (CypE). |
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V3140 | OSS-128167 | 887686-02-4 | OSS_128167 (formerly SIRT6-IN-1) is a novel, potent and selectiveSIRT6inhibitor withIC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. |
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V0429 | Selisistat (SEN0014196; EX 527) | 49843-98-3 | Selisistat (formerly SEN-0014196; EX-527) is a novel, highlypotent and selective inhibitor of SIRT1 (Sirtuin1, aNAD-dependent and class III histone deacetylase enzyme) with important biological activity. |
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V0439 | SirReal2 | 709002-46-0 | SirReal2 is a novel, highly potent and isoform-selective inhibitor of Sirt2 (Sirtuin 2) with potential anticancer and anti-inflammatory activity. |
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V79902 | SIRT1 activator 1 | SIRT1 activator 1(compound 3) is an analogue of the marine compound xyloallenoide a extracted from the mangrove fungus Xylaria sp. | |
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V81396 | SIRT5 inhibitor 8 | SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50= 5.38 μM) of sirtuin SIRT5 and has anti-cancer potential. | |
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V81397 | SIRT5 inhibitor 9 | SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor of sirtuin SIRT5 (IC50= 4.07 μM) and has anti-cancer potential. | |
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V41860 | SIRT7 inhibitor 97491 | 1807758-81-1 | SIRT7 inhibitor 97491 is a novel SIRT7 inhibitor with antitumor activity. |
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V4054 | SRT1720 | 925434-55-5 | SRT1720 (formerly known as CAY10559) is a novel and selective SIRT1 activator with an EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. |
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V0428 | SRT1720 HCL (CAY-10559) | 1001645-58-4 | SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt ofSRT1720, is a novel, potent and selective SIRT1(Sirtuin 1) activator with potential anticancer activity and isa promising new therapeutic agent for treating type 2 diabetes. |
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V0438 | SRT2104 (GSK-2245840) | 1093403-33-8 | SRT2104 (formerly GSK-2245840; SRT2104;GSK2245840;SRT-2104) is a novel, first-in-class, brain penetrant, and highly selective small molecule activator of SIRT1 (Sirtuin 1) with potential use forneurodegenerative diseases. |
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V2699 | SRT3025 HCL | 2070015-26-6 | SRT3025 is an orally bioactive small molecule activator of the SIRT1 enzyme. |
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V11213 | Lithospermic acid B | 121521-90-2 | Lithospermic acid B (Dan Shen Suan B, Salvianolic acid B) is a naturally occuring and potent antioxidant which iswater-soluble and found in Salvia extract. |
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V0437 | Splitomicin (Splitomycin) | 5690-03-9 | Splitomicin (known also as Splitomycin), a lactone derived from naphthol, is a potent, cell-permeable and selective inhibitor of NAD(+)-dependent histone deacetylase (HDAC) Sir2p with potential antineoplastic activity. |
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