Sirtuin (Sir2 proteins) are a group of proteins that have deacylase activity, such as deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V78969 | CypD-IN-4 | 3023438-19-6 | CypD-IN-4 is a potent isoform-selective cyclophilin D (CypD) inhibitor. |
|
V78970 | CypE-IN-1 | 3023438-33-4 | CypD-IN-1 is a potent isoform-selective inhibitor of cyclophilin E (CypE). |
|
V79902 | SIRT1 activator 1 | SIRT1 activator 1(compound 3) is an analogue of the marine compound xyloallenoide a extracted from the mangrove fungus Xylaria sp. | |
|
V81396 | SIRT5 inhibitor 8 | SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50= 5.38 μM) of sirtuin SIRT5 and has anti-cancer potential. | |
|
V81397 | SIRT5 inhibitor 9 | SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor of sirtuin SIRT5 (IC50= 4.07 μM) and has anti-cancer potential. |
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