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Sirtuin

Sirtuin

Sirtuin (Sir2 proteins) are a group of proteins that have deacylase activity, such as deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.

Sirtuin related products

Structure Cat No. Product Name CAS No. Product Description
AGK2 V0436 AGK2 304896-28-4 AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity.
AK-1 V6633 AK-1 330461-64-8 AK-1 is a potent, specific and cell-penetrating/penetrable SIRT2 inhibitor (antagonist) with IC50 of 12.5 μM.
AK-7 V4086 AK-7 420831-40-9 AK-7 (also known as AK7, CS-3223 and GL-8955) is a novel, selective, cell- and brain-permeable SITR2 inhibitor with the potential to be used for the treatment of Parkinsons disease and Huntingtons disease (HD).
Cambinol V3226 Cambinol 14513-15-6 Cambinol (formerly NSC-112546) is a potent SIRT (silent information regulator enzymes) inhibitor withIC50values of 56 and 59 μM for SIRT1andSIRT2, respectively.
CAY10602 V2111 CAY10602 374922-43-7 CAY10602 (CAY-10602) is a novel and potentSIRT1activator.
CypD-IN-4 V78969 CypD-IN-4 CypD-IN-4 is a potent isoform-selective cyclophilin D (CypD) inhibitor.
CypE-IN-1 V78970 CypE-IN-1 CypD-IN-1 is a potent isoform-selective inhibitor of cyclophilin E (CypE).
Fisetin (Fustel; CCRIS-9034; NSC-407010) V0435 Fisetin (Fustel; CCRIS-9034; NSC-407010) 528-48-3 Fisetin (Fustel; CCRIS9034; NSC40701; 3, 7, 3′, 4′-tetrahydroxyflavone) is a naturally occuring and dietary flavonoid isolated from/found in a variety of fruits and vegetables (i.
Lithospermic acid B V11213 Lithospermic acid B 121521-90-2 Lithospermic acid B (Dan Shen Suan B, Salvianolic acid B) is a naturally occuring and potent antioxidant which iswater-soluble and found in Salvia extract.
Nicotinamide (Vitamin B3) V0432 Nicotinamide (Vitamin B3) 98-92-0 Nicotinamide (Vitamin B3; Niacinamide; Nicotinic acid amide), awater-soluble and active form of vitamin B3, is a potent and active component of coenzymes NAD and NADP.
OSS-128167 V3140 OSS-128167 887686-02-4 OSS_128167 (formerly SIRT6-IN-1) is a novel, potent and selectiveSIRT6inhibitor withIC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
Resveratrol (SRT501; RM1812) V0430 Resveratrol (SRT501; RM1812) 501-36-0 Resveratrol, also known as trans-Resveratrol,SRT-501 and RM-1812, is a naturally occuring phytoalexin produced by several plants with anti-cancer, antioxidant, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Selisistat (SEN0014196; EX 527) V0429 Selisistat (SEN0014196; EX 527) 49843-98-3 Selisistat (formerly SEN-0014196; EX-527) is a novel, highlypotent and selective inhibitor of SIRT1 (Sirtuin1, aNAD-dependent and class III histone deacetylase enzyme) with important biological activity.
SirReal2 V0439 SirReal2 709002-46-0 SirReal2 is a novel, highly potent and isoform-selective inhibitor of Sirt2 (Sirtuin 2) with potential anticancer and anti-inflammatory activity.
SIRT1 activator 1 V79902 SIRT1 activator 1 SIRT1 activator 1(compound 3) is an analogue of the marine compound xyloallenoide a extracted from the mangrove fungus Xylaria sp.
SIRT5 inhibitor 8 V81396 SIRT5 inhibitor 8 SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50= 5.38 μM) of sirtuin SIRT5 and has anti-cancer potential.
SIRT5 inhibitor 9 V81397 SIRT5 inhibitor 9 SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor of sirtuin SIRT5 (IC50= 4.07 μM) and has anti-cancer potential.
SIRT7 inhibitor 97491 V41860 SIRT7 inhibitor 97491 1807758-81-1 SIRT7 inhibitor 97491 is a novel SIRT7 inhibitor with antitumor activity.
Sirtinol V0431 Sirtinol 410536-97-9 Sirtinol is a cell-permeable andspecific inhibitor of the sirtuin deacetylase 1/2 (SIRT1/2) with potential anticancer and anti-inflammatory activity.
Splitomicin (Splitomycin) V0437 Splitomicin (Splitomycin) 5690-03-9 Splitomicin (known also as Splitomycin), a lactone derived from naphthol, is a potent, cell-permeable and selective inhibitor of NAD(+)-dependent histone deacetylase (HDAC) Sir2p with potential antineoplastic activity.
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