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Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine.These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response, which entails dilating the pupils of the eyes, mobilizing energy, and rerouting blood flow away from skeletal muscle to non-essential organs, is controlled by the sympathetic nervous system.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.

Adrenergic Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(-)-Isoproterenol hydrochloride V101112 (-)-Isoproterenol hydrochloride 5984-95-2 (-)-Isoproterenol (L-isoproterenol; Proternol L) hydrochloride is a β-adrenergic receptor agonist.
(Rac)-Nebivolol-d2,15N V87631 (Rac)-Nebivolol-d2,15N (Rac)-Nebivolol-d2,15N is 15N and deuterium labeled (Rac)-Nebivolol.
(Rac)-Nebivolol-d4 hydrochloride ((Rac)-R 065824-d4 hydrochloride) V84080 (Rac)-Nebivolol-d4 hydrochloride ((Rac)-R 065824-d4 hydrochloride) 2701283-32-9
(S)-Atenolol V101375 (S)-Atenolol 93379-54-5 (S)-Atenolol is a potent β-adrenergic receptor blocker.
3,4-Dihydro-6,7-isoquinolinediol V92173 3,4-Dihydro-6,7-isoquinolinediol 4602-83-9 3,4-Dihydro-6,7-isoquinolinediol (compound 7) is a β2-AR agonist with EC50 of 106.9 μM in CH-K1/GA1S cells.
4-Hydroxy nebivolol hydrochloride V101068 4-Hydroxy nebivolol hydrochloride 2717115-85-8 4-Hydroxynebivolol (4-OH nebivolol) hydrochloride is the active β-blocking hydrolytic metabolite of nebivolol.
5,6-Epoxyeicosatrienoic acid V86520 5,6-Epoxyeicosatrienoic acid 87173-80-6 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic form of the enantiomer biosynthesized from arachidonic acid by cytochrome P450 enzymes.
Aclidinium V98017 Aclidinium 727649-81-2 Aclidinium bromide is a long-acting muscarinic antagonist and long-acting β2-adrenergic receptor (β2-AR) agonist with bronchodilatory effects.
ADRA2A antagonist 1 V89031 ADRA2A antagonist 1 ADRA2A antagonist 1 (compd 4n) is a potent and selective ADRA2A antagonist with IC50 of 18 nM.
Amibegron V94737 Amibegron 121524-08-1 Amibegron is a selective β3-adrenergic receptor agonist with an EC50 of 3.5 nM for rat colonic β-adrenergic receptors; Amibegron has anxiolytic and antidepressant effects.
Amitraz-d6 V87770 Amitraz-d6 2734300-36-6 Amitraz-d6 (BTS-27419-d6) is the deuterated derivative of Amitraz.
Apraclonidine dihydrochloride (ALO 2145 dihydrochloride) V86143 Apraclonidine dihydrochloride (ALO 2145 dihydrochloride) 73217-88-6 Apraclonidine (ALO 2145) dihydrochloride is a selective α2 and weak α1 receptor agonist
BAY-6096 V85241 BAY-6096 2313483-41-7
Bedoradrine V94462 Bedoradrine 194785-19-8 Bedoradrine is a highly selective β2-adrenergic agonist with activity in suppressing asthma and chronic obstructive pulmonary disease (COPD).
BRL-37344 V87767 BRL-37344 90730-96-4 BRL-37344 is a specific β3-adrenergic receptor agonist.
CHF-6550 V101689 CHF-6550 3052116-62-5 CHF-6550 is a muscarinic M3 receptor antagonist and β2 adrenergic receptor agonist (maba) with pKi of 9.3 and 10.6, respectively.
Cirazoline V87814 Cirazoline 59939-16-1 Cirazoline (LD 3098) is a dual agonist of presynaptic imidazoline receptors (R(i-pre)) and α-adrenergic receptors (R(α)).
CL 316243 free acid V101410 CL 316243 free acid 183720-02-7 CL316243 free acid is a potent and selective β3-adrenoceptor agonist with an EC50 of 3 nM, but has poor selectivity for β1/2 receptors.
Colterol acetate V101848 Colterol acetate 10255-14-8 Colterol acetate is a selective beta-adrenergic receptor inhibitor.
Dicentrine hydrochloride V94439 Dicentrine hydrochloride 5742-03-0 Metformin hydrochloride is a drug with anti-inflammatory and anticancer activities.
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