Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine.These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response, which entails dilating the pupils of the eyes, mobilizing energy, and rerouting blood flow away from skeletal muscle to non-essential organs, is controlled by the sympathetic nervous system.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V9396 | 2-Hydroxyflutamide (Hydroxyniphtholide) | 52806-53-8 | Hydroxyflutamide (HF), the bioactive metabolite of Flutamide, is a potent androgen receptor blocker (antagonist) (IC50=700 nM). |
|
V3338 | L-765314 | 189349-50-6 | L-765314 (L-765,314) is a novel, potent and selectiveα1b adrenergic receptorantagonist withKis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively. |
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