APJ

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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APJ

Apelin is an endogenous ligand for an APJ that was previously isolated from the stomachs of cows, and the Apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs). The hydrolysis of the 77-amino acid precursor protein apelin results in the production of active peptides with various lengths, including apelin-36, apelin-31, apelin-17, and apelin-13. A number of organs' physiology and pathophysiology depend on the apelin/APJ system, which also controls blood pressure, cardiac contractility, angiogenesis, metabolic balance, and cell growth, apoptosis, and inflammation. Additionally, the central nervous system exhibits widespread apelin/APJ system expression, particularly in neurons and oligodendrocytes. Additionally, APJ contributes to depression and anxiety.

APJ related products

Cat No.	Product Name	CAS No.	Product Description
V86534	[Pyr1]-Apelin-13, Gly(15N) TFA		[Pyr1]-Apelin-13, Gly(15N) TFA is Gly15N-labeled [Pyr1]-Apelin-13.
V75307	AM-8123	2049973-02-4	AM-8123 is an orally bioavailable APJ agonist.
V78095	Apelin-17(human, bovine) TFA		Apelin-17 (human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist.
V78096	Apelin-36(human) TFA		Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist/activator with EC50 of 20 nM.
V78097	Apelin-36(rat, mouse) TFA		Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist.
V75315	APJ receptor agonist 1	2287153-38-0	APJ receptor agonist 1 is a biphenyl acid analogue and a potent APJ receptor (APJ-R) agonist (EC50s of 0.093 and 0.12 nM for human and rat APJ-R, respectively).
V75308	APJ receptor agonist 3	2759159-56-1	APJ receptor agonist (activator) 3 is a potent orally bioactive APJ receptor agonist (activator) with EC50 of 0.027 nM.
V75313	APJ receptor agonist 4	2762567-70-2	APJ receptor agonist 4 is a potent, orally bioactive apelin receptor (APJ) agonist/activator with EC50 and Ki of 0.06 nM and 0.07 nM.
V75312	APJ receptor agonist 5	2135514-20-2	APJ receptor agonist 5 (compound 3) is a potent orally bioactive apelin receptor (APJ) agonist/activator with EC50 of 0.4 nM.
V75305	APJ receptor agonist 8	2049973-39-7	APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor.
V75304	BMS-986224	2055200-88-7	BMS-986224 is a specific and orally bioactive APJ receptor agonist (Kd = 0.3 nM) that displays similar receptor binding and signaling profiles to (Pyr1) apelin-13.
V74628	ELA-11(human)	1784687-32-6	ELA-11 (human), a peptide, is a full agonist of the human apelin receptor with pKi of 7.85.
V74627	ELA-21 (human)	2245073-05-4	ELA-21 (human) is an apelin receptor agonist/activator with pKi of 8.52.
V75310	ELA-32(human)	1680205-79-1	ELA-32 (human) is a potent peptide critical for cardiac development that acts through the G-protein–coupled apelin receptor.
V74625	Elabela(19-32)	1886973-05-2	Elabela(19-32) is the active fragment of ELABELA (ELA) that binds to the apelin receptor (APJ).
V3030	ML221	877636-42-5	ML221 is a potent functional antagonist of the apelin (APJ) receptor.
V75311	ML233	2080311-92-6	ML233 is a non-peptide, potent apelin receptor (APJ) agonist (EC50=3.7 μM).
V75306	MM 54	1313027-43-8	MM 54 (compound 5) is a competitive APJ antagonist (inhibitor) with IC50 of 93 nM.
V75309	NH2-c[XRLSX]-KGP-(D-1Nal)	2891469-80-8	NH2-c[XRLSX]-KGP-(D-1Nal) (compound 39) is a potent APJ agonist/activator with Ki of 0.6 nM.
V75314	NH2-c[XRLSX]-KGP-(D-2Nal)	2891469-81-9	NH2-c[XRLSX]-KGP-(D-2Nal) (compound 40) is a macrocyclic analog of Ape13 and a potent APJ agonist (Ki=5.7 nM).