Apelin is an endogenous ligand for an APJ that was previously isolated from the stomachs of cows, and the Apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs). The hydrolysis of the 77-amino acid precursor protein apelin results in the production of active peptides with various lengths, including apelin-36, apelin-31, apelin-17, and apelin-13. A number of organs' physiology and pathophysiology depend on the apelin/APJ system, which also controls blood pressure, cardiac contractility, angiogenesis, metabolic balance, and cell growth, apoptosis, and inflammation. Additionally, the central nervous system exhibits widespread apelin/APJ system expression, particularly in neurons and oligodendrocytes. Additionally, APJ contributes to depression and anxiety.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75307 | AM-8123 | 2049973-02-4 | AM-8123 is an orally bioavailable APJ agonist. |
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V78095 | Apelin-17(human, bovine) TFA | Apelin-17 (human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. | |
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V78096 | Apelin-36(human) TFA | Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist/activator with EC50 of 20 nM. | |
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V78097 | Apelin-36(rat, mouse) TFA | Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. | |
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V75315 | APJ receptor agonist 1 | 2287153-38-0 | APJ receptor agonist 1 is a biphenyl acid analogue and a potent APJ receptor (APJ-R) agonist (EC50s of 0.093 and 0.12 nM for human and rat APJ-R, respectively). |
|
V75308 | APJ receptor agonist 3 | 2759159-56-1 | APJ receptor agonist (activator) 3 is a potent orally bioactive APJ receptor agonist (activator) with EC50 of 0.027 nM. |
|
V75313 | APJ receptor agonist 4 | 2762567-70-2 | APJ receptor agonist 4 is a potent, orally bioactive apelin receptor (APJ) agonist/activator with EC50 and Ki of 0.06 nM and 0.07 nM. |
|
V75312 | APJ receptor agonist 5 | 2135514-20-2 | APJ receptor agonist 5 (compound 3) is a potent orally bioactive apelin receptor (APJ) agonist/activator with EC50 of 0.4 nM. |
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V75305 | APJ receptor agonist 8 | 2049973-39-7 | APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor. |
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V75304 | BMS-986224 | 2055200-88-7 | BMS-986224 is a specific and orally bioactive APJ receptor agonist (Kd = 0.3 nM) that displays similar receptor binding and signaling profiles to (Pyr1) apelin-13. |
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V74628 | ELA-11(human) | 1784687-32-6 | ELA-11 (human), a peptide, is a full agonist of the human apelin receptor with pKi of 7.85. |
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V74627 | ELA-21 (human) | 2245073-05-4 | ELA-21 (human) is an apelin receptor agonist/activator with pKi of 8.52. |
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V75310 | ELA-32(human) | 1680205-79-1 | ELA-32 (human) is a potent peptide critical for cardiac development that acts through the G-protein–coupled apelin receptor. |
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V74625 | Elabela(19-32) | 1886973-05-2 | Elabela(19-32) is the active fragment of ELABELA (ELA) that binds to the apelin receptor (APJ). |
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V3030 | ML221 | 877636-42-5 | ML221 is a potent functional antagonist of the apelin (APJ) receptor. |
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V75311 | ML233 | 2080311-92-6 | ML233 is a non-peptide, potent apelin receptor (APJ) agonist (EC50=3.7 μM). |
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V75306 | MM 54 | 1313027-43-8 | MM 54 (compound 5) is a competitive APJ antagonist (inhibitor) with IC50 of 93 nM. |
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V75309 | NH2-c[XRLSX]-KGP-(D-1Nal) | 2891469-80-8 | NH2-c[XRLSX]-KGP-(D-1Nal) (compound 39) is a potent APJ agonist/activator with Ki of 0.6 nM. |
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V75314 | NH2-c[XRLSX]-KGP-(D-2Nal) | 2891469-81-9 | NH2-c[XRLSX]-KGP-(D-2Nal) (compound 40) is a macrocyclic analog of Ape13 and a potent APJ agonist (Ki=5.7 nM). |
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