Histone acetyltransferases (HATs) are epigenetic proteins that attach acetyl groups to lysine residues in cellular proteins like histones, transcription factors, nuclear receptors, and enzymes. In eukaryotic cells, HATs are essential for chromatin remodeling and transcriptional control. Through the acetylation of both histone and non-histone proteins, HATs have been shown to play a role in diseases ranging from cancer and inflammatory disorders to neurological disorders.
At least five different subfamilies of HATs (HAT1, Gcn5/PCAF, MYST, p300/CBP, and Rtt109) can be distinguished. HATs mediate a wide range of biological functions, such as hormone signaling, dosage adjustment, DNA damage repair, and cell cycle progression. A number of human diseases, such as solid tumors, leukemias, inflammatory lung disease, viral infection, diabetes, fungus infection, and drug addiction, are associated with abnormal HAT function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V88875 | (E/Z)-NiCur | 63476-70-0 | (E/Z)-NiCur is the active isomer of NiCur. |
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V121976 | (R,R)-dWIZ-1 TFA | (R,R)-dWIZ-1 TFA is the (R,R)-enantiomer of dWIZ-1. | |
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V107451 | 3,5-DMA hydrochloride | 24973-29-3 | 3,5-DMA (3,5-dimethoxyamphetamine) hydrochloride is an alkylaniline compound that is preferentially catalyzed by NAT2. Its metabolic rate is closely related to the acetylation type of NAT2. 3,5-DMA can be used to study the role of NAT2 acetylation type in the metabolism of alkylaniline carcinogens. |
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V126150 | 4-Aminonaphthalen-1-yl acetate | 858186-27-3 | 4-Aminonaphthalen-1-yl acetate is a 4-amino-1-naphthol derivative and a negative control reagent for lysine (K) acetyltransferase KAT8. |
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V9859 | A-485 | 1889279-16-6 | A-485 (A485) is a potent, drug-like and selective HAT (histone acetyltransferase) inhibitor of p300/CBP with potential antitumor activity. |
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V84850 | Antitumor agent-130 | ||
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V115100 | ARHB | 2310262-15-6 | ARHB is a highly selective and sensitive NAT2 fluorescent probe suitable for real-time detection of NAT2 activity in a variety of bacteria. |
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V129651 | AUR1545 | 3031593-79-7 | AUR1545 is a selective KAT2A/KAT2B ((GCN5/PCAF)) PROTAC degrader that can induce monocyte differentiation and inhibit the growth of acute myeloid leukemia cells. |
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V103705 | BAY-184 | 2520347-03-7 | BAY-184 is a selective, oral KAT6A and KAT6B inhibitor. |
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V129915 | BAY-7728 | 2767642-46-4 | BAY-7728 is an orally effective selective dual inhibitor of KAT6A (IC50: 45 nM) and KAT6B (IC50: 95 nM). |
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V130414 | BMS-986470 | 3036554-12-5 | BMS-986470 is an HbF-activated CRBN E3 ligase modulator (CELMoD), an orally effective bimolecular gel degrader that targets ZBTB7A and WIZ. |
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V2519 | C646 | 328968-36-1 | C646 is a potent, selective and competitive inhibitor for histone acetyltransferase p300. |
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V88873 | CAY10669 | 1243583-88-1 | CAY10669 (compound 6d) is an Anacardic Acid derivative that inhibits histone acetyltransferase (PCAF) with IC50 of 662 μM. |
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V131169 | CBP/p300 ligand 10 | 3098454-51-1 | CBP/p300 ligand 10 is a CBP/p300 degradation agent. |
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V131170 | CBP/p300 ligand-Linker Conjugate 3 | 3102127-04-5 | CBP/p300 ligand-Linker Conjugate 3 is a target protein ligand-linker conjugate that contains a CBP/p300 ligand and a PROTAC linker that recruits E3 ligases. |
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V52296 | CBP/p300-IN-10 | 2259641-71-7 | CBP/p300-IN-10 is a potent inhibitor of histone acetyltransferases EP300 and CREBBP, with IC50s of 26 nM and 39 nM respectively. |
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V41054 | CBP/p300-IN-5 | 1889284-33-6 | P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase with IC50 of 18.8 nM. |
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V131171 | CBP/p300/BRD4 ligand-1 | 3086024-48-5 | CBP/p300/BRD4 ligand-1 is a small molecule inhibitor that targets CBP, p300, and BRD4. |
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V88866 | CBPD-268 | CBPD-268 is a potent and orally active CBP/p300 PROTAC degrader with a DC50 value of ≤ 0.03 nM. | |
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V88871 | CPTH2-Alkyne | 1613116-16-7 | CPTH2-Alkyne is a cell-active analog of CPTH2. |
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