Histone Acetyltransferase

Histone Acetyltransferase

Histone acetyltransferases (HATs) are epigenetic proteins that attach acetyl groups to lysine residues in cellular proteins like histones, transcription factors, nuclear receptors, and enzymes. In eukaryotic cells, HATs are essential for chromatin remodeling and transcriptional control. Through the acetylation of both histone and non-histone proteins, HATs have been shown to play a role in diseases ranging from cancer and inflammatory disorders to neurological disorders.
At least five different subfamilies of HATs (HAT1, Gcn5/PCAF, MYST, p300/CBP, and Rtt109) can be distinguished. HATs mediate a wide range of biological functions, such as hormone signaling, dosage adjustment, DNA damage repair, and cell cycle progression. A number of human diseases, such as solid tumors, leukemias, inflammatory lung disease, viral infection, diabetes, fungus infection, and drug addiction, are associated with abnormal HAT function.

Histone Acetyltransferase related products

Structure Cat No. Product Name CAS No. Product Description
V9859 A-485 1889279-16-6 A-485 (A485) is a potent, drug-like and selective HAT (histone acetyltransferase) inhibitor of p300/CBP with potential antitumor activity.
V2522 Anacardic Acid (Hydroginkgolic acid) 16611-84-0 Anacardic Acid(Hydroginkgolic acid), a natural product isolated from cashew nut shell liquid, is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
V84850 Antitumor agent-130
V2519 C646 328968-36-1 C646 is a potent, selective and competitive inhibitor for histone acetyltransferase p300.
V52296 CBP/p300-IN-10 2259641-71-7 CBP/p300-IN-10 is a potent inhibitor of histone acetyltransferases EP300 and CREBBP, with IC50s of 26 nM and 39 nM respectively.
V41054 CBP/p300-IN-5 1889284-33-6 P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase with IC50 of 18.8 nM.
V3344 CTB 451491-47-7 CTB (also known as Cholera Toxin B subunit) is a potent activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
V18876 Curcumin 458-37-7 Curcumin (Diferuloylmethane; NSC32982;Turmeric Yellow; curcumin I) is a naturally occurring diarylheptanoiddiarylheptanoid withdiverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.
V52155 DS-9300 2259641-46-6 DS-9300 is a potent, orally bioactive and selective EP300/CBP HAT inhibitor (antagonist) with IC50 of 28 nM.
V52120 Ep300/CREBBP-IN-2 2259641-59-1 Ep300/CREBBP-IN-2 (Example 73) is a potent and orally bioactive inhibitor of Ep300 and CREBBP with IC50 of 0.052 μM and 0.148 μM, respectively.
V52119 Ep300/CREBBP-IN-3 2259641-47-7 Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor (antagonist) with IC50 of 0.056 μM and 0.095 μM, respectively.
V52118 Ep300/CREBBP-IN-4 2259641-42-2 Ep300/CREBBP-IN-4 (Example 56) is a potent inhibitor of Ep300 and CREBBP with IC50 of 0.024 μM and 0.064 μM, respectively.
V52117 Ep300/CREBBP-IN-8 2259641-24-0 Ep300/CREBBP-IN-8 (Example 37) is a potent and orally bioactive inhibitor of Ep300 and CREBBP with IC50 of 0.014 μM and 0.018 μM, respectively.
V2998 I-CBP112 1640282-31-0 I-CBP112 (I-CBP-112) is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor (PPI) with anticancer activity.
V75851 JG-2016 2887480-87-5 JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1) with IC50 of 14.8 μM in HAT1 acetylation assay[1].
V51910 KAT modulator-1 1314006-43-3 KAT modulator-1 (Compound 3) is a KAT modulator.
V53267 KAT6-IN-1 2569008-99-5 KAT6-IN-1 is a potent inhibitor of KAT6.
V76803 Lys-CoA TFA Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM).
V79730 MC4171 MC4171 (Compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM).
V2520 MG149 1243583-85-8 MG-149 (MG149) is a novel, potent and selectivehistone acetyltransferase (HAT) inhibitor with anticancer activity.
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