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Src

Src

Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways. Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Structure Cat No. Product Name CAS No. Product Description
V3630 1-Naphthyl PP1(1-NA-PP 1) 221243-82-9 1-Naphthyl PP1 (also known as 1-NA-PP1) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively.
V3629 1-Naphthyl PP1(1-NA-PP1) HCl 956025-47-1 1-Naphthyl PP1 HCl (also known as 1-NA-PP1 hydrochloride) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively.
V3628 1-NM-PP1 221244-14-0 1-NM-PP1,a C3-modified analog of PP1, is a novel, potent and cell permeable protein kinase D (PKD) inhibitor with anIC50of 0.398 μM.1-NM-PP1 has shown the selective inhibition of protein kinases that have been mutated with the IC50 values of 28 μM, 1.0 μM, 3.4 μM, 29 μM, 24 μM,4.3 nM, 3.2 nM, 120 nM,5 nM and 8 nM for v-Src, c-Fyn, c-Abl, CDK2, CAMKII, v-Src-as1, c-Fyn-as1, cAbl-as2, CDK2-as1 and CAMKII-as1, respectively.
V77786 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide that binds to the src SH2 domain (IC50≈1 µM).
V3462 AMG-47a 882663-88-9 AMG-47a is a novel, potent inhibitor of Lck and T cell proliferation which exhibits anti-inflammatory activity with ED50 of 11 mg/kg in the anti-CD3 induced production of IL-2 in mice.
V69771 Antiallergic agent-1 2839159-12-3 Antiallergic agent-1 is a Src family kinase inhibitor and may serve as a new valuable lead compound for the discovery of antiallergic active molecules in the future.
V2984 AZM475271 476159-98-5 AZM475271 is a potent, selective and oral inhibitor of Src kinase with IC50 of 5 nM and with potential anticancer activities; it has no inhibitory activity on Flt3, KDR, Tie-2.
V2486 Bosutinib hydrate 918639-08-4 Bosutinib hydrate (SKI606; KIN001160; SKI-606; KIN-001160;Bosulif), the mono-hydrated form of bosutinib, is a synthetic quinolone derivative and dual kinase inhibitor targeting both Abl and Src kinases with potential antineoplastic activity.
V69764 BT424 2755180-37-9 BT424 is a specific HCK inhibitor.
V69778 Caffeic acid-pYEEIE 507471-72-9 Caffeic acid-pYEEIE is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain.
V77175 Caffeic acid-pYEEIE TFA Caffeic acid-pYEEIE TFA is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain.
V78736 CGP77675 hydrate CGP77675 hydrate is an orally bioavailable Src family kinase inhibitor.
V69772 DC-Srci-6649 1037545-61-1 DC-Srci-6649 is a c-Src kinase inhibitor that can suppress phosphorylation and locks c-Src in an inactive state.
V69768 EPQpYEEIPIYL 147612-86-0 EPQpYEEIPIYL is a phosphopeptide and Src homology 2 (SH2) domain ligand.
V69766 iHCK-37 (ASN05260065) 516478-09-4 iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor (antagonist) with a Ki of 0.22 μM.
V23236 KIN001-051 213743-31-8 KIN001-051 (Lck inhibitor; C-8863; KIN-001-051) is a novel, potent, cell-permeable and ATP-competitive inhibitor of Lymphocyte-specific protein tyrosine kinase (LCK, IC50s）.
V2889 KX1-004 518058-84-9 KX1-004 is a novel and potent small molecule inhibitor of Src-protein tyrosine kinase that can be used to reduce cisplatin ototoxicity while preserving its antitumor effect.
V69773 LCB 03-0110 dihydrochloride 1962928-28-4 LCB 03-0110 di-HCl is the di-HCl salt of LCB 03-0110.
V4777 Lck inhibitor 2 944795-06-6 Lck inhibitor 2, a bis-anilinopyrimidine derivative, is a novel and potent multi-kinase inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK with IC50 values of 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
V69777 Lck-IN-1 923596-52-5 Lck-IN-1 is a potent lymphocyte PTK (protein tyrosine kinase) (Lck) inhibitor.
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