Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways. Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V3629 | 1-Naphthyl PP1(1-NA-PP1) HCl | 956025-47-1 | 1-Naphthyl PP1 HCl (also known as 1-NA-PP1 hydrochloride) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. |
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V4777 | Lck inhibitor 2 | 944795-06-6 | Lck inhibitor 2, a bis-anilinopyrimidine derivative, is a novel and potent multi-kinase inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK with IC50 values of 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. |
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V3630 | 1-Naphthyl PP1(1-NA-PP 1) | 221243-82-9 | 1-Naphthyl PP1 (also known as 1-NA-PP1) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. |
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V3628 | 1-NM-PP1 | 221244-14-0 | 1-NM-PP1,a C3-modified analog of PP1, is a novel, potent and cell permeable protein kinase D (PKD) inhibitor with anIC50of 0.398 μM.1-NM-PP1 has shown the selective inhibition of protein kinases that have been mutated with the IC50 values of 28 μM, 1.0 μM, 3.4 μM, 29 μM, 24 μM,4.3 nM, 3.2 nM, 120 nM,5 nM and 8 nM for v-Src, c-Fyn, c-Abl, CDK2, CAMKII, v-Src-as1, c-Fyn-as1, cAbl-as2, CDK2-as1 and CAMKII-as1, respectively. |
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V77786 | Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA | Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide that binds to the src SH2 domain (IC50≈1 µM). | |
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V3462 | AMG-47a | 882663-88-9 | AMG-47a is a novel, potent inhibitor of Lck and T cell proliferation which exhibits anti-inflammatory activity with ED50 of 11 mg/kg in the anti-CD3 induced production of IL-2 in mice. |
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V69771 | Antiallergic agent-1 | 2839159-12-3 | Antiallergic agent-1 is a Src family kinase inhibitor and may serve as a new valuable lead compound for the discovery of antiallergic active molecules in the future. |
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V2984 | AZM475271 | 476159-98-5 | AZM475271 is a potent, selective and oral inhibitor of Src kinase with IC50 of 5 nM and with potential anticancer activities; it has no inhibitory activity on Flt3, KDR, Tie-2. |
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V69764 | BT424 | 2755180-37-9 | BT424 is a specific HCK inhibitor. |
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V69778 | Caffeic acid-pYEEIE | 507471-72-9 | Caffeic acid-pYEEIE is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain. |
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V77175 | Caffeic acid-pYEEIE TFA | Caffeic acid-pYEEIE TFA is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain. | |
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V78736 | CGP77675 hydrate | CGP77675 hydrate is an orally bioavailable Src family kinase inhibitor. | |
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V69772 | DC-Srci-6649 | 1037545-61-1 | DC-Srci-6649 is a c-Src kinase inhibitor that can suppress phosphorylation and locks c-Src in an inactive state. |
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V69768 | EPQpYEEIPIYL | 147612-86-0 | EPQpYEEIPIYL is a phosphopeptide and Src homology 2 (SH2) domain ligand. |
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V69766 | iHCK-37 (ASN05260065) | 516478-09-4 | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor (antagonist) with a Ki of 0.22 μM. |
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V23236 | KIN001-051 | 213743-31-8 | KIN001-051 (Lck inhibitor; C-8863; KIN-001-051) is a novel, potent, cell-permeable and ATP-competitive inhibitor of Lymphocyte-specific protein tyrosine kinase (LCK, IC50s). |
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V2889 | KX1-004 | 518058-84-9 | KX1-004 is a novel and potent small molecule inhibitor of Src-protein tyrosine kinase that can be used to reduce cisplatin ototoxicity while preserving its antitumor effect. |
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V69773 | LCB 03-0110 dihydrochloride | 1962928-28-4 | LCB 03-0110 di-HCl is the di-HCl salt of LCB 03-0110. |
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V69777 | Lck-IN-1 | 923596-52-5 | Lck-IN-1 is a potent lymphocyte PTK (protein tyrosine kinase) (Lck) inhibitor. |
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V69770 | Osteogenic Growth Peptide (10-14) (OGP(10-14); Historphin) | 105250-85-9 | Osteogenic Growth Peptide (10-14) (OGP(10-14)) is a C-terminal truncated pentapeptide of osteogenic growth peptide (OGP) that retains intact OGP-like activity. |