Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V2840 | BMS-687453 | 1000998-59-3 | BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with anEC50andIC50of 10 nM and 260 nM for humanPPARαand 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays. |
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V0831 | FH535 | 108409-83-2 | FH535 (FH-535; FH 535) is a novel and potent dual inhibitor of the Wnt/β-catenin and the PPAR (γ/δ) pathways with potential antitumor activity. |
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V0830 | GSK3787 | 188591-46-0 | GSK3787 (GSK-3787; GSK 3787) isa novel, potent, selective and irreversible antagonist of PPARδ (Peroxisome proliferator-activated receptor δ) with important biological activity. |
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V0832 | GW0742 | 317318-84-6 | GW0742 (GW-0742; GW 0742; GW-0742X; GW0742X; GW610742; GW-610742) is a potent and highly selective PPARβ/δ agonist with potential anti-inflammatory activity. |
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V4916 | GW6471 | 880635-03-0 | GW 6471 (GW6471; GW-6471) is a novel and potentPPARαantagonistwith an IC50 of 0.24 μ M. |
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V0826 | GW9662 | 22978-25-2 | GW9662 (GW-9662; GW 9662) is an irreversible and selective inhibitor of PPAR (peroxisome proliferator-activated receptor) with potential anticancer activity. |
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V0827 | T0070907 | 313516-66-4 | T0070907 (T-0070907; T 0070907) is a potent and selective PPARγ (Peroxisome proliferator-activated receptor γ) inhibitor with potential anti-inflammatory activity. |
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V0828 | Pioglitazone | 111025-46-8 | Pioglitazone (U-72107A;AD-4833;Actos; AD4833, U-72107E) is approved and thiazolidinedione-based anti-diabetic drug which acts as a selective PPARϒ (Peroxisome proliferator-activated receptor γ) agonist with hypoglycemic activity. |
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V0829 | WY-14643 (Pirinixic Acid) | 50892-23-4 | Pirinixic Acid (also known as NSC 310038; NSC310038;WY-14643; WY 14643) is a novel, highly potent and selective peroxisome proliferator and activator of PPARα with important biological activity. |
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V0835 | Gemfibrozil | 25812-30-0 | Gemfibrozil (Pilder; CI-719;CI719;CI 719; Lopid; Jezil; Lipur; Trialmin) is a potent anti-hypertriglyceridemic/lipid lowering drug acting as an activator/agonist of peroxisome proliferator-activated receptor-alpha (PPARα). |
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V17606 | Pemafibrate [(R)-K-13675] | 848259-27-8 | Pemafibrate [(R)-K 13675; K877; Parmodia], a drug used for the reduction of triglycerides,is a potent agonist ofperoxisome proliferator-activated receptor alpha(PPAR alpha/PPARα) with EC50 of 1 nM. |
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V10867 | Alpinetin | 36052-37-6 | Alpinetin is a natural flavonoid isolated from Alpinia katsumadai Hayata with potent anti-inflammatory activity. |
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V2726 | Troglitazone | 97322-87-7 | Troglitazone (formerly known as CI991) is a novel potent PPARγ agonist with anti-inflammatory and anti-tumor activity. |
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V30081 | Oroxin A | 57396-78-8 | Oroxin A is the major component of Oroxylum indicum (L. |
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V0837 | Clofibric Acid | 882-09-7 | Clofibric acid (BRN-1874067; CCRIS 9254;BRN1874067;NSC 1149; NSC1149;Chlorofibrinic acid), theactive metabolite of clofibrate, etofibrate and theofibrate (the lipid-lowering drugs), is a potentPPARα agonist and anti-hyperlipidemic agent. |
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V0833 | Ciprofibrate | 52214-84-3 | Ciprofibrate (BRN-1984981; CCRIS 173; CCRIS173;Win-35833; BRN 1984981; BRN1984981;CCRIS-173) is a potent and selective agonist of PPAR/peroxisome proliferator-activated receptor agonist with antilipidemic activity. |
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V0838 | Rosiglitazone HCl | 302543-62-0 | Rosiglitazone HCl (HSDB-7555;BRL-49653;TDZ-01;BRL49653), the hydrochloride salt ofRosiglitazone,is a potent antidiabetic/antihyperglycemic drug of the thiazolidinedione class with anti-inflammatoryactivities. |
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V0825 | Rosiglitazone | 122320-73-4 | Rosiglitazone (HSDB-7555; BRL-49653; TDZ-01; TDZ01; trade name Avandia)is an approved antidiabetic drug of the thiazolidinedione classwith antidiabetic properties and potential antineoplastic activity. |
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V0836 | Bezafibrate | 41859-67-0 | Bezafibrate (BM 15075; BM-15075; Benzofibrate;BM15075; Bezalip; Bezatrol; Difaterol; Cedur; Bezafibratum) is an anti-hypertriglyceridemic/lipid-lowering drug acting. |
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V4569 | Astaxanthin | 472-61-7 | Astaxanthin is a naturally occurring red dietary carotenoid isolated from Haematococcus pluvialis anda keto-carotenoid that belongs to a larger class of chemical compounds known as terpenes (as a tetraterpenoid) built from five carbon precursors, isopentenyl diphosphate, and dimethylallyl diphosphate. |
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