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PPAR

PPAR

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.

PPAR related products

Structure Cat No. Product Name CAS No. Product Description
Alpinetin V10867 Alpinetin 36052-37-6 Alpinetin is a natural flavonoid isolated from Alpinia katsumadai Hayata with potent anti-inflammatory activity.
Astaxanthin V4569 Astaxanthin 472-61-7 Astaxanthin is a naturally occurring red dietary carotenoid isolated from Haematococcus pluvialis anda keto-carotenoid that belongs to a larger class of chemical compounds known as terpenes (as a tetraterpenoid) built from five carbon precursors, isopentenyl diphosphate, and dimethylallyl diphosphate.
Bezafibrate V0836 Bezafibrate 41859-67-0 Bezafibrate (BM 15075; BM-15075; Benzofibrate;BM15075; Bezalip; Bezatrol; Difaterol; Cedur; Bezafibratum) is an anti-hypertriglyceridemic/lipid-lowering drug acting.
BMS-687453 V2840 BMS-687453 1000998-59-3 BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with anEC50andIC50of 10 nM and 260 nM for humanPPARαand 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.
Ciprofibrate V0833 Ciprofibrate 52214-84-3 Ciprofibrate (BRN-1984981; CCRIS 173; CCRIS173;Win-35833; BRN 1984981; BRN1984981;CCRIS-173) is a potent and selective agonist of PPAR/peroxisome proliferator-activated receptor agonist with antilipidemic activity.
Clofibric Acid V0837 Clofibric Acid 882-09-7 Clofibric acid (BRN-1874067; CCRIS 9254;BRN1874067;NSC 1149; NSC1149;Chlorofibrinic acid), theactive metabolite of clofibrate, etofibrate and theofibrate (the lipid-lowering drugs), is a potentPPARα agonist and anti-hyperlipidemic agent.
Fenofibrate V0834 Fenofibrate 49562-28-9 Fenofibrate (Tricor, Procetofen, LF-178, Lipanthyl, NSC-281319;Controlip,Normalip, Secalip, durafenat, Trilipix) is afibric acid based anti-hyperlipidemic drug of the fibrate class approved for clinical uses as a lipid-lowering agent.
FH535 V0831 FH535 108409-83-2 FH535 (FH-535; FH 535) is a novel and potent dual inhibitor of the Wnt/β-catenin and the PPAR (γ/δ) pathways with potential antitumor activity.
Gemfibrozil V0835 Gemfibrozil 25812-30-0 Gemfibrozil (Pilder; CI-719;CI719;CI 719; Lopid; Jezil; Lipur; Trialmin) is a potent anti-hypertriglyceridemic/lipid lowering drug acting as an activator/agonist of peroxisome proliferator-activated receptor-alpha (PPARα).
GSK3787 V0830 GSK3787 188591-46-0 GSK3787 (GSK-3787; GSK 3787) isa novel, potent, selective and irreversible antagonist of PPARδ (Peroxisome proliferator-activated receptor δ) with important biological activity.
GW0742 V0832 GW0742 317318-84-6 GW0742 (GW-0742; GW 0742; GW-0742X; GW0742X; GW610742; GW-610742) is a potent and highly selective PPARβ/δ agonist with potential anti-inflammatory activity.
GW6471 V4916 GW6471 880635-03-0 GW 6471 (GW6471; GW-6471) is a novel and potentPPARαantagonistwith an IC50 of 0.24 μ M.
GW9662 V0826 GW9662 22978-25-2 GW9662 (GW-9662; GW 9662) is an irreversible and selective inhibitor of PPAR (peroxisome proliferator-activated receptor) with potential anticancer activity.
Oroxin A V30081 Oroxin A 57396-78-8 Oroxin A is the major component of Oroxylum indicum (L.
Pemafibrate [(R)-K-13675] V17606 Pemafibrate [(R)-K-13675] 848259-27-8 Pemafibrate [(R)-K 13675; K877; Parmodia], a drug used for the reduction of triglycerides,is a potent agonist ofperoxisome proliferator-activated receptor alpha(PPAR alpha/PPARα) with EC50 of 1 nM.
Pioglitazone V0828 Pioglitazone 111025-46-8 Pioglitazone (U-72107A;AD-4833;Actos; AD4833, U-72107E) is approved and thiazolidinedione-based anti-diabetic drug which acts as a selective PPARϒ (Peroxisome proliferator-activated receptor γ) agonist with hypoglycemic activity.
Rosiglitazone V0825 Rosiglitazone 122320-73-4 Rosiglitazone (HSDB-7555; BRL-49653; TDZ-01; TDZ01; trade name Avandia)is an approved antidiabetic drug of the thiazolidinedione classwith antidiabetic properties and potential antineoplastic activity.
Rosiglitazone HCl V0838 Rosiglitazone HCl 302543-62-0 Rosiglitazone HCl (HSDB-7555;BRL-49653;TDZ-01;BRL49653), the hydrochloride salt ofRosiglitazone,is a potent antidiabetic/antihyperglycemic drug of the thiazolidinedione class with anti-inflammatoryactivities.
Rosiglitazone maleate V0824 Rosiglitazone maleate 155141-29-0 Rosiglitazone maleate (TDZ01;HSDB-7555; TDZ-01;BRL-49653; trade name Avandia), the maleic acid salt form of rosiglitazone which is an approved anti-diabetic drug,is a thiazolidinedione-based antihyperglycaemic agent with antidiabetic properties and potential antineoplastic activity.
T0070907 V0827 T0070907 313516-66-4 T0070907 (T-0070907; T 0070907) is a potent and selective PPARγ (Peroxisome proliferator-activated receptor γ) inhibitor with potential anti-inflammatory activity.
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