Endothelin Receptor

Endothelin Receptor

Endothelin ligands, which are 21 amino acid long peptides derived from longer prepro-endothelin precursors, bind to endothelin receptors, G protein-coupled receptors (GPCRs) of the -group of rhodopsin receptors. At least four types are recognized: ETA, ETB (ETB1, ETB2), and ETC. The ETB receptor has an equivalently high affinity for all three endothelin isopeptides, whereas the ETA receptor exhibits high affinity and selectivity for ET-1 and ET-2 over ET-3.

Vascular endothelium (ET-1 exclusively) and smooth muscle cells are two tissues that produce endothelins. Endothelin receptors ETA and ETB, found on vascular smooth muscle cells that mediate vasoconstriction and the endothelium that is associated with the release of nitric oxide (NO) and prostacyclin, respectively, bind to released endothelin.

Endothelin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V77466 [Ala1,3,11,15]-Endothelin (53-63) (TFA)
V75339 [Ala2] Endothelin-3, human 2243207-08-9
V75341 [Asn18] Endothelin-1, human 309245-97-4
V75338 [Lys4] Sarafotoxin S6c 1219444-22-0
V75337 ACT-373898 1433875-14-9
V1512 Ambrisentan (BSF 208075; LU 208075) 177036-94-1 Ambrisentan (formerly BSF-208075; LU-208075; BSF208075; LU208075; Letairis; Volibris; pulmonext) is a selective antagonist of the endothelin-1 type A receptor (ETA).
V75335 ANP (1-30), frog 309245-16-7
V4421 Atrasentan 173937-91-2 Atrasentan (ABT-627; NSC720763; A-147627; trade name: Xinlay) is a novel, selective and potent endothelin receptor/ET antagonist with anticancer activity.
V4422 Atrasentan HCl 195733-43-8 Atrasentan HCl, the hydrochloride salt of Atrasentan (NSC-720763; ABT-627; A-147627; trade name: Xinlay), is a novel and selective endothelin receptor antagonist (IC50 = 0.0551 nM for ETA) with anticancer activity.
V75342 Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) 102686-43-1
V77230 Atrial natriuretic Peptide (ANP) (1-28), rat TFA (Atrial natriuretic factor (1-28) (rat) TFA)
V1513 Bosentan 147536-97-8 Bosentan (formerly Ro 47-0203; brand name Tracleer) is a potent, competitive and dual antagonist of endothelin (ET) receptor with anti-hypertensive activity.
V1509 Bosentan Hydrate (Ro 47-0203) 157212-55-0 Bosentan Hydrate (also known as Ro 47-0203; Ro47-0203; Ro-47-0203; Tracleer) is a potent, competitive and dual endothelin (ET) A/B receptor antagonist for ET-A and ET-B with anti-hypertensive activity.
V75336 Bosentan-d4 1065472-77-6
V1514 BQ-123 136553-81-6 BQ-123 (Cyclo(D-trp-D-asp-pro-D-val-leu); BQ123; BQ 123) is a potent andselective antagonist of endothelin A receptor (ETAR) with an IC50 of 7.3 nM.
V78540 BQ-123 TFA
V77187 BQ-3020 ammonium
V75333 CI-1020 (PD156707) 162256-50-0
V75332 Endothelin 1 (swine, human) (TFA) 394693-38-0
V79302 Endothelin 1 (swine, human), Alexa Fluor 488-labeled
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