Endothelin Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Endothelin Receptor

Endothelin ligands, which are 21 amino acid long peptides derived from longer prepro-endothelin precursors, bind to endothelin receptors, G protein-coupled receptors (GPCRs) of the -group of rhodopsin receptors. At least four types are recognized: ETA, ETB (ETB1, ETB2), and ETC. The ETB receptor has an equivalently high affinity for all three endothelin isopeptides, whereas the ETA receptor exhibits high affinity and selectivity for ET-1 and ET-2 over ET-3.

Vascular endothelium (ET-1 exclusively) and smooth muscle cells are two tissues that produce endothelins. Endothelin receptors ETA and ETB, found on vascular smooth muscle cells that mediate vasoconstriction and the endothelium that is associated with the release of nitric oxide (NO) and prostacyclin, respectively, bind to released endothelin.

Endothelin Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V77466	[Ala1,3,11,15]-Endothelin (53-63) (TFA)		[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist.
V75339	[Ala2] Endothelin-3, human	2243207-08-9	[Ala2] Endothelin-3, human is a linear analog of endothelin ET-3 in which Ala replaces the Cys residue.
V75341	[Asn18] Endothelin-1, human	309245-97-4	[Asn18] Endothelin-1, human is a polypeptide.
V75338	[Lys4] Sarafotoxin S6c	1219444-22-0	[Lys4] Sarafotoxin S6c is a sarafotoxin analogue and a potent partial agonist of the endothelin receptor.
V75337	ACT-373898	1433875-14-9	ACT-373898 is an inactive carboxylic acid metabolite of Macitentan.
V75335	ANP (1-30), frog	309245-16-7	ANP (1-30), frog is a polypeptide fragment of frog-derived atrial peptide.
V75342	Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human))	102686-43-1	Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a bioactive peptide hormone synthesized and secreted by the atrial myocardium.
V77230	Atrial natriuretic Peptide (ANP) (1-28), rat TFA (Atrial natriuretic factor (1-28) (rat) TFA)		Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is the major circulating form of atrial natriuretic peptide (ANP) in rats and potently inhibits angiotensin II (Ang II)-stimulated endothelin- 1 (endothelin-1) secretion.
V75336	Bosentan-d4	1065472-77-6	Bosentan-d4 is the deuterium labelled form of Bosentan.
V78540	BQ-123 TFA		BQ-123 TFA is a potent and specific endothelin A (ETA) receptor antagonist (inhibitor) with IC50 of 7.3 nM and a Ki of 25 nM.
V77187	BQ-3020 ammonium		BQ-3020 ammonium is an endothelin receptor (ETBreceptor) agonist.
V75333	CI-1020 (PD156707)	162256-50-0	CI-1020 (PD156707) is an orally bioactive selective antagonist targeting endothelin (ETA) with IC50 of 0.3 nM.
V86600	Clazosentan disodium	503271-02-1	Clazosentan disodium (Ro 61-1790) is a selective endothelin A receptor (ETA receptor) antagonist.
V85769	Edonentan hydrate (BMS 207940 hydrate)	264609-13-4
V75332	Endothelin 1 (swine, human) (TFA)	394693-38-0	Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and porcine endothelin 1 and is a potent endogenous vasoconstrictor.
V79302	Endothelin 1 (swine, human), Alexa Fluor 488-labeled		Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic peptide of Endothelin 1 labeled with 488 fluorescence.
V77038	Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) (TFA))		Endothelin-3, human, mouse, rabbit, rat TFA is a vasoactive peptide consisting of 21 amino acid (AA)s that binds to G protein-linked transmembrane receptors, ET-RA and ET-RB.
V76879	IRL-1620 TFA		IRL-1620 (TFA) is a potent and specific endorphin receptor (endothelin receptor) type B agonist/activator with a Ki of 16 pM.
V86599	Methylsolfonyl 25(S)-Δ7-dafachronic acid		Methylsolfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with IC50 of 0.41 μM.
V75334	Nebentan potassium (YM598)	342005-82-7	Nebentan potassium (YM598) is a potent, orally bioactive, non-peptide endothelin receptor (ETA receptor) antagonist modified by Bosentan.