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Endothelin Receptor

Endothelin Receptor

Endothelin ligands, which are 21 amino acid long peptides derived from longer prepro-endothelin precursors, bind to endothelin receptors, G protein-coupled receptors (GPCRs) of the -group of rhodopsin receptors. At least four types are recognized: ETA, ETB (ETB1, ETB2), and ETC. The ETB receptor has an equivalently high affinity for all three endothelin isopeptides, whereas the ETA receptor exhibits high affinity and selectivity for ET-1 and ET-2 over ET-3.

Vascular endothelium (ET-1 exclusively) and smooth muscle cells are two tissues that produce endothelins. Endothelin receptors ETA and ETB, found on vascular smooth muscle cells that mediate vasoconstriction and the endothelium that is associated with the release of nitric oxide (NO) and prostacyclin, respectively, bind to released endothelin.

Endothelin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
[Ala1,3,11,15]-Endothelin (53-63) (TFA) V77466 [Ala1,3,11,15]-Endothelin (53-63) (TFA) [Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist.
[Ala2] Endothelin-3, human V75339 [Ala2] Endothelin-3, human 2243207-08-9 [Ala2] Endothelin-3, human is a linear analog of endothelin ET-3 in which Ala replaces the Cys residue.
[Asn18] Endothelin-1, human V75341 [Asn18] Endothelin-1, human 309245-97-4 [Asn18] Endothelin-1, human is a polypeptide.
[Lys4] Sarafotoxin S6c V75338 [Lys4] Sarafotoxin S6c 1219444-22-0 [Lys4] Sarafotoxin S6c is a sarafotoxin analogue and a potent partial agonist of the endothelin receptor.
ACT-373898 V75337 ACT-373898 1433875-14-9 ACT-373898 is an inactive carboxylic acid metabolite of Macitentan.
ANP (1-30), frog V75335 ANP (1-30), frog 309245-16-7 ANP (1-30), frog is a polypeptide fragment of frog-derived atrial peptide.
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) V75342 Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) 102686-43-1 Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a bioactive peptide hormone synthesized and secreted by the atrial myocardium.
Atrial natriuretic Peptide (ANP) (1-28), rat TFA (Atrial natriuretic factor (1-28) (rat) TFA) V77230 Atrial natriuretic Peptide (ANP) (1-28), rat TFA (Atrial natriuretic factor (1-28) (rat) TFA) Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is the major circulating form of atrial natriuretic peptide (ANP) in rats and potently inhibits angiotensin II (Ang II)-stimulated endothelin- 1 (endothelin-1) secretion.
Bosentan-d4 V75336 Bosentan-d4 1065472-77-6 Bosentan-d4 is the deuterium labelled form of Bosentan.
BQ-123 TFA V78540 BQ-123 TFA BQ-123 TFA is a potent and specific endothelin A (ETA) receptor antagonist (inhibitor) with IC50 of 7.3 nM and a Ki of 25 nM.
BQ-3020 ammonium V77187 BQ-3020 ammonium BQ-3020 ammonium is an endothelin receptor (ETBreceptor) agonist.
CI-1020 (PD156707) V75333 CI-1020 (PD156707) 162256-50-0 CI-1020 (PD156707) is an orally bioactive selective antagonist targeting endothelin (ETA) with IC50 of 0.3 nM.
Clazosentan disodium V86600 Clazosentan disodium 503271-02-1 Clazosentan disodium (Ro 61-1790) is a selective endothelin A receptor (ETA receptor) antagonist.
Edonentan hydrate (BMS 207940 hydrate) V85769 Edonentan hydrate (BMS 207940 hydrate) 264609-13-4
Endothelin 1 (swine, human) (TFA) V75332 Endothelin 1 (swine, human) (TFA) 394693-38-0 Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and porcine endothelin 1 and is a potent endogenous vasoconstrictor.
Endothelin 1 (swine, human), Alexa Fluor 488-labeled V79302 Endothelin 1 (swine, human), Alexa Fluor 488-labeled Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic peptide of Endothelin 1 labeled with 488 fluorescence.
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) (TFA)) V77038 Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) (TFA)) Endothelin-3, human, mouse, rabbit, rat TFA is a vasoactive peptide consisting of 21 amino acid (AA)s that binds to G protein-linked transmembrane receptors, ET-RA and ET-RB.
IRL-1620 TFA V76879 IRL-1620 TFA IRL-1620 (TFA) is a potent and specific endorphin receptor (endothelin receptor) type B agonist/activator with a Ki of 16 pM.
Methylsolfonyl 25(S)-Δ7-dafachronic acid V86599 Methylsolfonyl 25(S)-Δ7-dafachronic acid Methylsolfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with IC50 of 0.41 μM.
Nebentan potassium (YM598) V75334 Nebentan potassium (YM598) 342005-82-7 Nebentan potassium (YM598) is a potent, orally bioactive, non-peptide endothelin receptor (ETA receptor) antagonist modified by Bosentan.
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