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P2Y Receptor

P2Y Receptor

G protein-coupled receptors (GPCRs) known as P2Y receptors are activated by the extracellular nucleotides ATP, UTP, and UDP. Mammalian P2Y receptors come in eight different subtypes: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14. The P2Y receptors play significant roles in physiology and pathophysiology, including inflammatory reactions and neuropathic pain, and are expressed in a variety of cell types.

The P2Y family can be further divided into two subfamilies: P2Y12, P2Y13, and P2Y14Rs ("P2Y12-like"), which inhibit adenylate cyclase through Gi protein, and P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs ("P2Y1-like"), which stimulate phospholipase C (PLC) through Gq protein. Other effector pathways have also been identified, such as the coupling of the P2Y11R to Gs and Gq in some cells to stimulate the production of cyclic AMP.

P2Y Receptor related products

Structure Cat No. Product Name CAS No. Product Description
2-MeS-ATP V86719 2-MeS-ATP 43170-89-4 2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and is specific for adenosine nucleotide activation as a P2Y purinergic receptor agonist.
2-MeSADP V86711 2-MeSADP 34983-48-7 2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic (P2Y) receptor agonist with EC50 of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13, and human P2Y12, respectively.
2-Methylthio-AMP (2-MeSAMP; 2-Methylthioadenosine 5′-monophosphate; 2-Methylthioadenosine 5′-phosphate) V74436 2-Methylthio-AMP (2-MeSAMP; 2-Methylthioadenosine 5′-monophosphate; 2-Methylthioadenosine 5′-phosphate) 22140-20-1 2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist.
2-Methylthio-AMP diTEA (2-MeSAMP diTEA; 2-Methylthioadenosine 5′-monophosphate diTEA; 2-Methylthioadenosine 5′-phosphate diTEA) V74442 2-Methylthio-AMP diTEA (2-MeSAMP diTEA; 2-Methylthioadenosine 5′-monophosphate diTEA; 2-Methylthioadenosine 5′-phosphate diTEA) 1227193-98-7 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist.
2-Thio-UTP V86724 2-Thio-UTP 35763-29-2 2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 of 50 nM.
2-Thio-UTP tetrasodium (2-Thiouridine 5′-triphosphate tetrasodium) V84494 2-Thio-UTP tetrasodium (2-Thiouridine 5′-triphosphate tetrasodium) 1343364-70-4
2-甲基硫代二磷酸腺苷 V3528 2MeSADP 475193-31-8 2MeSADP is a novel and potent purinergic agonist which acts by displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors and inhibiting cAMP accumulation.
3-O-Methylquercetin tetraacetate (Quercetin 3-O-methyl ether peracetate) V74435 3-O-Methylquercetin tetraacetate (Quercetin 3-O-methyl ether peracetate) 1486-69-7 3-O-Methylquercetin tetraacetate is an antiplatelet agent.
4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP tetralithium) V74448 4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP tetralithium) 20188-72-1 4-Thouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent agonist of P2Y2 and P2Y4 with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively.
4-Thiouridine 5′-triphosphate tetrasodium V86710 4-Thiouridine 5′-triphosphate tetrasodium 68507-49-3 4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium is a potent agonist of P2Y2 and P2Y4, with EC50 values of 35 and 350 nM for hP2Y2 and hP2Y4, respectively.
4-Thouridine 5′-triphosphate tetrasodium (4-Thio-UTP tetrasodium) V77629 4-Thouridine 5′-triphosphate tetrasodium (4-Thio-UTP tetrasodium) 4-Thouridine 5′-triphosphate (4-Thio-UTP) tetrasodium is a potent agonist of P2Y2 and P2Y4 with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively.
5'-TMPS V86715 5'-TMPS 15548-51-3 5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y6R and an antagonist of P2Y14R.
5'-UMPS V86722 5'-UMPS 15548-52-4 5'-UMPS (Uridine-5'-O-monophosphorothioate) is a P2Y14 receptor agonist.
5-OMe-UDP V86713 5-OMe-UDP 1207530-98-0 5-OMe-UDP (5-Methoxyuridine 5'-trihydrogen diphosphate) is a P2Y6 receptor agonist (EC50=0.08 μM).
Adenosine 2',5'-diphosphate sodium V51183 Adenosine 2',5'-diphosphate sodium 154146-84-6 Adenosine 2',5'-sodium diphosphate is a competitive P2Y1 antagonist.
ADP-β-S trilithium V86704 ADP-β-S trilithium 73536-95-5 ADP-β-S trilithium is the trilithium salt form of ADP-β-S.
Ap4C tetrasodium V86714 Ap4C tetrasodium 1352921-13-1 Ap4C tetrasodium is a dinucleoside polyphosphate containing purine and pyrimidine bases.
ATP-γ-S tetrasodium V74434 ATP-γ-S tetrasodium 88453-52-5 ATP-γ-S tetrasodium is an ATP analog and a P2Y11 receptor agonist.
AZD-1283 V4242 AZD-1283 919351-41-0 AZD1283 is a novel, potent and selective antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10 and with binding IC50 of 11 nM.
Blue FPG-A trisodium V73575 Blue FPG-A trisodium 78617-94-4 Blue FPG-A trisodium is a selective P2X1 receptor and P2Y1 receptor antagonist (inhibitor) with IC50s of 35.5 μM and 2.6 μM respectively.
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