One of the most deadly pathogens for primates is the filovirus. Lethal hemorrhagic fever is brought on by filoviruses in both humans and nonhuman primates. Marburgvirus, which includes different strains of the Lake Victoria marburgvirus (MARV), and Ebolavirus (EBOVs), which includes four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV), as well as a tentative species Bundibugyo ebolavirus (BEBOV).
The infections typically spread throughout the body's organs and are frequently accompanied by bleeding. The virus can then spread from person to person after being transferred from an animal host to a human.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52513 | 2'-Deoxy-5'-O-DMT-2'-fluorouridine | 146954-74-7 | 2'-Deoxy-5'-O-DMT-2'-fluorouridine is a nucleoside analog and an analogue of 5'-O-DMTr-5-FUDR. |
|
V128324 | ADI-15878 | ADI-15878 is a human IgG monoclonal antibody (mAb) that targets the envelope glycoprotein GP2. | |
|
V88245 | Antiviral agent 12 | 314030-54-1 | Antiviral agent 12 is an antiviral compound. |
|
V98452 | Antiviral agent 59 | Antiviral agent 59 (compound 58) is a selective and drug-like antiviral agent that inhibits a variety of filoviruses. | |
|
V105085 | Antiviral agent 66 | Antiviral agent 66 (compound 60) is a filovirus inhibitor that inhibits pseudotyped viruses of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston, and Tai Forest with EC50 values of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21, and 0.11 μM, respectively. | |
|
V2280 | ASN03576800 | 957513-35-8 | ASN03576800 may be a potent inhibitor of Ebola virus matrix protein VP40 during virus assembly and budding. |
|
V54249 | Cephaeline hydrochloride ((-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride) | 3738-70-3 | Cephaeline HCl ((-)-Cephaeline HCl) is a phenolic alkaloid in Indian Ipecac. |
|
V95224 | DB772 free base | 433735-90-1 | DB772 free base is a bovine viral diarrhea virus (BVDV) inhibitor. |
|
V2224 | Ebola and Marburg Entry Inhibitor | 2479465-67-1 | Ebola and Marburg Entry Inhibitor, a 4-(aminomethyl)benzamide-based compound, is a novel and potent entry inhibitor of Ebola and Marburg rirus infections. |
|
V134872 | EBOV entry-IN-1 | EBOV entry-IN-1 is an EBOV entry inhibitor with an IC50 of 1.50 μM. | |
|
V134873 | EBOV entry-IN-2 | EBOV entry-IN-2 is an EBOV invasion inhibitor with an EC50 of 4.42 μM. | |
|
V54170 | EBOV-IN-1 | 1335113-30-8 | EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor (blocker/antagonist) of Ebola virus (EBOV). |
|
V134874 | EBOV-IN-11 | 752216-12-9 | EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor with Kd values of 1.88 nM for wild-type and 8.01 nM for quadruple mutant PP1. |
|
V88241 | EBOV-IN-2 | EBOV-IN-2 (Compound 2) is an Ebola virus (EBOV) inhibitor with IC50 values of 0.37 μM and 2.54 μM against Ebola virus glycoprotein pseudotyped virus (pEBOV) and African swine fever virus (ASFV), respectively. | |
|
V88237 | EBOV-IN-3 | 2896193-40-9 | EBOV-IN-3 (compound 9) is a benzothiazepine compound. |
|
V88242 | EBOV-IN-4 | 2896193-43-2 | EBOV-IN-4 (compound 12) is a benzothiazepine-type drug and a potent Ebola virus (EBOV) inhibitor with an inhibition rate of 64.9% against EBOV-GP pseudotyped virus (pEBOV) at 10 μM. EBOV-IN-4 is inactive against ASFV. |
|
V134875 | EBOV-IN-5 | 68207-15-8 | EBOV-IN-5 is an antiviral drug that can inhibit Ebola virus (EBOV) infection. |
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V88240 | EBOV-IN-6 | EBOV-IN-6 (compound 19) is a benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with IC50 of 10 μM. | |
|
V88238 | EBOV-IN-7 | 68207-16-9 | EBOV-IN-7 (compound 26) is an inhibitor of EBOV with an IC50 of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). |
|
V88239 | EBOV-IN-8 | 286854-12-4 | EBOV-IN-8 (Compound 30) inhibits Ebola pseudotyped virus (pEBOV) infection (IC50=62.1% 10 μM). |
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