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mAChR

mAChR

The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).

mAChR related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate) V77400 (+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate) (+)-Cevimeline HCl hemihydrate ((+)-SNI-2011) is a mAChR agonist.
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate) V77403 (-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate) (-)-Cevimeline HCl hemihydrate ((-)-SNI-2011) is a mAChR agonist.
(-)-Vesamicol (AH5183) V85954 (-)-Vesamicol (AH5183) 112709-59-8
(1R,3S-)Solifenacin-d5 hydrochloride V70547 (1R,3S-)Solifenacin-d5 hydrochloride 1217810-85-9 (1R,3S-)Solifenacin-d5 ( HCl) is the deuterated form of Solifenacin D5 HCl.
(R)-Oxybutynin hydrochloride (Aroxybutynin hydrochloride) V70518 (R)-Oxybutynin hydrochloride (Aroxybutynin hydrochloride) 1207344-05-5 (R)-Oxybutynin HCl is the racemic isomer of Oxybutynin HCl and is an orally bioactive muscarinic receptor antagonist.
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine; (Rac)-PNU-200577) V70507 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine; (Rac)-PNU-200577) 200801-70-3 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) is an bioactive metabolite of Tolterodine and an mAChR antagonist (Kis for M1, M2, M3, M4, and M5 receptors are 2.3 nM, 2 nM, 2.5 nM, 2.8 nM and 2.9 nM).
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride ((Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride) V70546 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride ((Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride) 250214-40-5 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) HCl is an bioactive metabolite of Tolterodine and an mAChR antagonist (Kis for M1, M2, M3, M4 and M5 receptors are 2.3 nM each) , 2 nM, 2.5 nM, 2.8 nM and 2.9 nM).
(Rac)-5-Hydroxymethyl Tolterodine-d14 ((Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14) V70549 (Rac)-5-Hydroxymethyl Tolterodine-d14 ((Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14) 1185071-13-9 (Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterated form of (Rac)-5-Hydroxymethyl Tolterodine.
[D-Trp7,9,10]-Substance P TFA V77479 [D-Trp7,9,10]-Substance P TFA [D-Trp7,9,10]-Substance P TFA is an analogue of substance P.
AC-42 hydrochloride V101196 AC-42 hydrochloride 447407-36-5 AC-42 HCl is the hydrochloride salt form of AC-42.
Antidepressant agent 6 V83603 Antidepressant agent 6
Arecaidine but-2-ynyl ester tosylate (ABET) V70498 Arecaidine but-2-ynyl ester tosylate (ABET) 119630-77-2 Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently reduces mean arterial pressure and heart rate in rats.
Arecaidine-propargyl ester tosylate V84784 Arecaidine-propargyl ester tosylate 147202-94-6
ASP8302 V90062 ASP8302 1839583-42-4 ASP8302 is a positive allosteric modulator of the muscarinic M3 receptor.
Atropine methyl nitrate V86661 Atropine methyl nitrate 52-88-0 Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and is the active molecule used for pupil dilation during ophthalmic examinations.
AZD-2115 V83201 AZD-2115 AZD-2115 is a muscarinic antagonist/beta 2 agonist (MABA).
Baogongteng A ((-)-Bao Gong Teng A) V84978 Baogongteng A ((-)-Bao Gong Teng A) 74239-84-2
Benztropine-d3 mesylate (benzatropine mesylate-d3; benztropine mesylate-d3) V70373 Benztropine-d3 mesylate (benzatropine mesylate-d3; benztropine mesylate-d3) 202529-16-6 Benztropine-d3 (mesylate) is the deuterated form of Benztropine (mesylate).
Bethanechol-d6 chloride (Carbamyl-β-methylcholine-d6 (chloride)) V78408 Bethanechol-d6 chloride (Carbamyl-β-methylcholine-d6 (chloride)) Bethanechol-d6 (chloride) is the deuterated form of Bethanechol chloride.
BQCA V4096 BQCA 338747-41-4 BQCA, a benzylquinolone carboxylic acid, is a potent, highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).
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