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mAChR

mAChR

The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).

mAChR related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate) V77400 (+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate) (+)-Cevimeline HCl hemihydrate ((+)-SNI-2011) is a mAChR agonist.
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate) V77403 (-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate) (-)-Cevimeline HCl hemihydrate ((-)-SNI-2011) is a mAChR agonist.
(-)-Vesamicol (AH5183) V85954 (-)-Vesamicol (AH5183) 112709-59-8
(1R,3S-)Solifenacin-d5 hydrochloride V70547 (1R,3S-)Solifenacin-d5 hydrochloride 1217810-85-9 (1R,3S-)Solifenacin-d5 ( HCl) is the deuterated form of Solifenacin D5 HCl.
(R)-Oxybutynin hydrochloride (Aroxybutynin hydrochloride) V70518 (R)-Oxybutynin hydrochloride (Aroxybutynin hydrochloride) 1207344-05-5 (R)-Oxybutynin HCl is the racemic isomer of Oxybutynin HCl and is an orally bioactive muscarinic receptor antagonist.
(Rac)-5-Carboxy tolterodine V107378 (Rac)-5-Carboxy tolterodine 1076199-77-3 (Rac)-5-Carboxytolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist tolterodine.
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine; (Rac)-PNU-200577) V70507 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine; (Rac)-PNU-200577) 200801-70-3 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) is an bioactive metabolite of Tolterodine and an mAChR antagonist (Kis for M1, M2, M3, M4, and M5 receptors are 2.3 nM, 2 nM, 2.5 nM, 2.8 nM and 2.9 nM).
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride ((Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride) V70546 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride ((Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride) 250214-40-5 (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) HCl is an bioactive metabolite of Tolterodine and an mAChR antagonist (Kis for M1, M2, M3, M4 and M5 receptors are 2.3 nM each) , 2 nM, 2.5 nM, 2.8 nM and 2.9 nM).
(Rac)-5-Hydroxymethyl Tolterodine-d14 ((Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14) V70549 (Rac)-5-Hydroxymethyl Tolterodine-d14 ((Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14) 1185071-13-9 (Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterated form of (Rac)-5-Hydroxymethyl Tolterodine.
(S)-Tolterodine V107033 (S)-Tolterodine 124937-53-7 (S)-Tolterodine is a muscarinic acetylcholine receptor (mAChR) inhibitor with IC50 of 588 nM.
(±)-Darifenacin N-Oxide V107616 (±)-Darifenacin N-Oxide 2416229-88-2 (±)-Darifenacin N-oxide is an impurity of darifenacin.
5-Hydroxymethyl tolterodine formate V105587 5-Hydroxymethyl tolterodine formate 380636-49-7 5-Hydroxymethyltolterodine (formate) (PNU-200577 (formate)) is the active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.
[D-Trp7,9,10]-Substance P TFA V77479 [D-Trp7,9,10]-Substance P TFA [D-Trp7,9,10]-Substance P TFA is an analogue of substance P.
AC-42 hydrochloride V101196 AC-42 hydrochloride 447407-36-5 AC-42 HCl is the hydrochloride salt form of AC-42.
Aceclidine hydrochloride V105497 Aceclidine hydrochloride 6109-70-2 Acetoclidin-3-yl acetate hydrochloride is a modulator of M3 muscarinic acetylcholine receptors and an agonist of M1 receptors (EC50: 40 μM).
Acetylethylcholine mustard hydrochloride V102851 Acetylethylcholine mustard hydrochloride 103994-00-9 Acetylcholine mustard hydrochloride is a choline acetyltransferase inhibitor that reduces the contraction frequency of myotubes by inhibiting the synthesis of acetylcholine (Ach) with a half-maximal inhibitory concentration (IC50) of 1.22 mM.
AE9C90CB V103083 AE9C90CB 893426-98-7 AE9C90CB is a muscarinic receptor antagonist with higher affinity for the M3 muscarinic receptor, with a pKi of 9.90, and is 20-fold more selective for the M3 muscarinic receptor than the M2 muscarinic receptor.
Antidepressant agent 6 V83603 Antidepressant agent 6
Arecaidine but-2-ynyl ester tosylate (ABET) V70498 Arecaidine but-2-ynyl ester tosylate (ABET) 119630-77-2 Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently reduces mean arterial pressure and heart rate in rats.
Arecaidine-propargyl ester tosylate V84784 Arecaidine-propargyl ester tosylate 147202-94-6
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