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Phosphatase

Phosphatase

Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.

Phosphatase related products

Structure Cat No. Product Name CAS No. Product Description
(-)-p-Bromotetramisole Oxalate V1929 (-)-p-Bromotetramisole Oxalate 62284-79-1 p-Bromotetramisole Oxalate (also known as L-p-Bromotetramisole Oxalate)is a potent,cell-permeable and non-specific alkaline phosphatase inhibitor.
(1S,2S,3R)-DT-061 V32191 (1S,2S,3R)-DT-061 1809427-20-0 1S,2S,3R)-DT-061 is an isomer/enantiomer of DT-061 (DT061), which is a novel and orally bioavailable activator of protein phosphatase 2A (PP2A) and may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
(24E)-3,4-Secocucubita-4,24-diene-3,26,29-trioic acid V73343 (24E)-3,4-Secocucubita-4,24-diene-3,26,29-trioic acid 329975-47-5 (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor (antagonist) with IC50=0.4 μM.
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane V73349 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane 1180504-64-6 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavone.
(E/Z)-Icerguastat acetate V87661 (E/Z)-Icerguastat acetate (E/Z)-Icerguastat ((E/Z)-Sephin1) acetate is a selective inhibitor of phosphatase regulatory subunit (PPP1R15A (R15A)).
(E/Z)-Raphin1 V89794 (E/Z)-Raphin1 94023-67-3 (E/Z)-Raphin1 is an inhibitor of PPP1R15B, a regulatory subunit of protein phosphatase 1.
(R)-Azasetron besylate (SENS-401) V73318 (R)-Azasetron besylate (SENS-401) 2025360-91-0 (R)-Azasetron besylate (SENS-401) is an orally bioactive calcineurin inhibitor.
(Rac)-RK-682 V73321 (Rac)-RK-682 154639-24-4 (Rac)-RK-682 is the racemate of RK-682 and is an inhibitor (blocker/antagonist) of protein tyrosine phosphatases (PTPases).
1-Naphthyl phosphate potassium salt V73312 1-Naphthyl phosphate potassium salt 100929-85-9 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor.
11R-CaN-AID V85688 11R-CaN-AID 650603-03-5
2-Bromo-4'-hydroxyacetophenone V73304 2-Bromo-4'-hydroxyacetophenone 2491-38-5 2-Bromo-4'-hydroxyacetophenone is a potent inhibitor of PTP1B with Ki of 42 μM.
2-Hydroxymethyl-3-hydroxyanthraquinone V73333 2-Hydroxymethyl-3-hydroxyanthraquinone 68243-30-1 2-Hydroxymethyl-3-hydroxyanthraquinone is an anti-osteoporotic compound that can inhibit osteoclast tartrate-resistant acid phosphatase (TRAP) activity.
3,5-Difluoro-L-tyrosine V73342 3,5-Difluoro-L-tyrosine 73246-30-7 3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine that may be utilized to analyze the substrate specificity of protein tyrosine phosphatase (PTP).
3α-AMINOCHOLESTANE (3AC) V3941 3α-AMINOCHOLESTANE (3AC) 2206-20-4 3α-Aminocholestane (also known as 3AC) is a potent and selectiveSH2 domain-containing inositol-5′-phosphatase 1(SHIP1) inhibitor with immunomodulatory and antitumor effects.
4-Methylumbelliferyl phosphate disodium (4-MUP disodium; MUP disodium) V73319 4-Methylumbelliferyl phosphate disodium (4-MUP disodium; MUP disodium) 22919-26-2 4-Methylumbelliferyl phosphate (4-MUP) disodium is an anionic organophosphate and a fluorescent substrate for acidic and alkaline phosphatase (phosphatase).
5-FAM-Alkyne V73311 5-FAM-Alkyne 510758-19-7 5-FAM-Alkyne is a selective and sensitive fluorescent biomarker that may be utilized to label alkaline phosphatase (ALP).
5MPN V73286 5MPN 47208-82-2 5MPN is a first-in-class, orally bioactive and selective inhibitor of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4).
[pTyr5] EGFR (988-993) (TFA) V77488 [pTyr5] EGFR (988-993) (TFA) [pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of the epidermal growth factor receptor (EGFR 988-993).
Acid Phosphatase (ACP), Sweet Potato V90026 Acid Phosphatase (ACP), Sweet Potato Acid Phosphatase (ACP), Sweet Potato (Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid Phosphatase, AcPase, Apase) are biomaterials or organic compounds that can be used as related to life science research.
Acid Phosphatase, Prostatic (ACP/PAP) V90025 Acid Phosphatase, Prostatic (ACP/PAP) Acid Phosphatase, Prostatic (ACP/PAP) (Acid Phos, 5'-nucleotidase, Thiamine monophosphatase, PAPf39) is a biomaterial or organic compound that can be used in life science research.
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