A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70662 | (+)-Cinchonaminone | 60305-15-9 | (+)-Cinchonaminone displays MAO (monoamine oxidase) inhibitory activity. |
|
V70685 | (±)-Amiflamine (FLA 336) | 77502-96-6 | (±)-Amiflamine (FLA 336) is a potent MAO (monoamine oxidase) (MAO-A) with pIC50 of 5.57. |
|
V70672 | 1,4-Naphthoquinone-d6 | 26473-08-5 | 1,4-Naphthoquinone-d6 is the deuterated form of 1,4-Naphthoquinone. |
|
V70693 | 1-Methyl-2-undecyl-4(1H)-quinolone | 59443-02-6 | 1-Methyl-2-undecyl-4(1H)-quinolone is a potent irreversible and selective monoamine oxidase type B (MAO-B) inhibitor. |
|
V70643 | 4-Hydroxyderricin | 55912-03-3 | 4-Hydroxyderricin is one of the main active ingredients of Ashitaba and is a potent and specific MAO-B (monoamine oxidase inhibitor) inhibitor (antagonist) with IC50 of 3.43 μM. |
|
V70678 | 6-Acetonyl-N-methyldihydrodecarine | 1253740-09-8 | 6-Acetonyl-N-methyldihydrodecarine is an alkaloid extracted from the roots of Zanthoxylum rigidum and is an inhibitor (blocker/antagonist) of MAO (monoamine oxidase). |
|
V70640 | Aminoacetone hydrochloride | 7737-17-9 | Aminoacetone HCl is the simplest single peptide. |
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V78050 | Antioxidant agent-13 | Antioxidant agent-13 (Compound 5f) is an antioxidant. | |
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V5896 | Bifemelane HCl | 62232-46-6 | Bifemelane HCl (MCI-2016) is a potent, selective and competitive inhibitor of MAO (monoamine oxidase) A (MAO-A) with Ki of 4.20 μM. |
|
V70684 | Chrysophanol-1-O-β-gentiobioside (Chrysophanol-1-O-β-gentiobioside) | 54944-38-6 | Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside extracted from Cassia seeds. |
|
V18542 | Clorgyline HCl (M&B 9302, MB9302) | 17780-75-5 | Clorgyline, formerly known as Clorgiline, M&B 9302 or MB9302, is a potent,irreversible and selective inhibitor of monoamine oxidase (MAO), it is structurally related to pargyline which is described as an antidepressant. |
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V70668 | Decaffeoylacteoside (Decaffeoylverbascoside; Verbasoside) | 61548-34-3 | Decaffeoylacteoside is an inhibitor (blocker/antagonist) of AChE/BChE/LOX with moderate activity. |
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V70669 | Echitovenidine | 7222-35-7 | Echitovenidine is an alkaloid extracted from Alstonia yunnanensis. |
|
V70670 | ETAP | 2575731-47-2 | ETAP is an MAO-A and MAO-B inhibitor. |
|
V70677 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate | 28705-46-6 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent hMAO-B selective inhibitor (antagonist) with IC50 of 45.52 μM. |
|
V67662 | Glicoricone | 161099-37-2 | Glicoricone is a phenolic compound extracted from licorice. |
|
V76938 | Harmane-d (Harmane-d1) | Harmane-d is the deuterium labelled form of Harmane. | |
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V79700 | Harmane-d2 (Harmane-d2) | Harmane-d2 is the deuterium labelled form of Harmane. | |
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V70654 | hMAO-B-IN-5 | 358343-63-2 | hMAO-B-IN-5(B15) is a specific and reversible inhibitor of human monoamine oxidase hMAO-B with IC50 of 0.12 μM. |
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V70661 | hMAO-B/MB-COMT-IN-1 | 254974-70-4 | hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: hMAO-B is 2.5 μM, MB-COMT is 3.84 μM). |
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