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Rho

Rho

The AGC (PKA/PKG/PKC) family of serine-threonine kinases includes ROCK (Rho-associated protein kinase). Animals such as chicken, zebrafish, Xenopus, and mammals also have ROCKs (ROCK1 and ROCK2). With a molecular weight of 158 kDa, human ROCK1 is a significant RhoA small GTPase downstream effector. A kinase domain, an acoiled-coil region, and a Pleckstrin homology (PH) domain make up a mammalian ROCK. If RhoA-GTP is absent, the kinase activity of ROCKs is reduced by an autoinhibitory intramolecular fold. Since ROCK is a downstream effector protein of the small GTPase Rho, one of the primary regulators of the cytoskeleton, ROCK is involved in a variety of different cellular phenomena.

Rho related products

Structure Cat No. Product Name CAS No. Product Description
1A-116 V9236 1A-116 1430208-73-3 1A-116 is a Rac1 inhibitor specific for the W56 residue, which can effectively prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction.
6H05 TFA V1571 6H05 TFA 2061344-88-3 6H05 TFA (6H-05; 6 H05), the trifluoroacetic acd salt of 6H05, is a potent, covalent, selective and allosteric inhibitor of K-Ras (G12C) which is oncogenic.
Azathioprine (BW 57-322) V1563 Azathioprine (BW 57-322) 446-86-6 Azathioprine (BW-57322; BW 57-322; Imuran; Azasan; Imurel; AZA; AZTP) is an approved immunosuppressive drug (prodrug of 6-MP) used in the treatment of organ transplantation and autoimmune diseases.
CASIN V17607 CASIN 425399-05-9 CASIN is a novel, potent and selective inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking.
CCG-100602 V17716 CCG-100602 1207113-88-9 CCG-100602 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling.
CCG-1423 V1567 CCG-1423 285986-88-1 CCG-1423 (CCG1423;CCG 1423) is a novel, potent and specific small-molecule inhibitor of RhoA signaling pathway with potential antitumor activity.
CCG-222740 V17719 CCG-222740 1922098-69-8 CCG-222740 (CCG222740) is a novel and potent Rho/myocardin-related transcription factor (MRTF)/SRF inhibitor.
EHop-016 V1562 EHop-016 1380432-32-5 EHop-016 (EHOP016;EHop 016)is a novel, potent and selective small molecule inhibitor of Rac GTPase with potential antineoplastic activity.
EHT 1864 2HCl V1566 EHT 1864 2HCl 754240-09-0 EHT 1864 2HCl (EHT-1864; EHT1864),the dihydrochloride salt of EHT-1864,is a potent and novel Rac family GTPase inhibitor with important biological activity.
K-Ras inhibitor 12 V1570 K-Ras inhibitor 12 1469337-95-8 K-Ras(G12C) inhibitor 12 is a co-valent and allosteric inhibitor of K-Ras G12C with potential antitumor activity.
K-Ras(G12C) inhibitor 9 V1572 K-Ras(G12C) inhibitor 9 1469337-91-4 K-Ras(G12C) inhibitor 9 is a novel, covalent and allosteric inhibitor of K-RAS G12C mutant with potential anticancer activity.
ML141(CID-2950007) V1569 ML141(CID-2950007) 71203-35-5 ML141 (also called CID-2950007; ML-141; CID2950007; ML 141)is a novel potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with potential anticancer activity.
MLS-573151 V40875 MLS-573151 10179-57-4 MLS-573151 is a novel, specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).
NSC 23766 V1561 NSC 23766 733767-34-5 NSC 23766 (NSC-23766; NSC23766) is a novel, selective and potent inhibitor of Rac GTPase withanti-influenza virus activity.
NSC-23766 3HCl V0012 NSC-23766 3HCl 1177865-17-6 NSC23766 3HCl, the salt form of NSC23766, is a novel and potent inhibitor of Rac GTPase that targets the activation of Rac by guanine nucleotide exchange factors (GEFs) with an IC50 of less than 50 μM in a test conducted without using cells; NSC23766 does not inhibit the closely related targets, Cdc42 or RhoA.
Salirasib (Farnesyl Thiosalicylic Acid) V1568 Salirasib (Farnesyl Thiosalicylic Acid) 162520-00-5 Salirasib (known also as S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS),a salicylic acid analog, is a potent and competitive prenylated protein methyltransferase (PPMTase) inhibitor with potential antineoplastic activity.
SAR407899 HCl V2029 SAR407899 HCl 923262-96-8 SAR407899 HCl is a novel, potent, selective, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
ZCL278 V1564 ZCL278 587841-73-4 ZCL278 (ZCL-278; ZCL 278) is a potent,cell-permeable and selective Cdc42 GTPase inhibitor with potential anticancer activity.
Zoledronic Acid (Zoledronate; CGP 42446) V1560 Zoledronic Acid (Zoledronate; CGP 42446) 118072-93-8 Zoledronic acid (Zoledronate; CGP-42446; CGP42446A; ZOL-446; Zometa; Reclast) is potent bisphosphonate with anti-bone-resorption activity.
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