The actin-related proteins Arp2 and Arp3 and the Arp2/3 complex subunits, ARPC1–5, which make up the Arp2/3 complex were first discovered in Acanthamoeba. They are conserved in all eukaryotes, with the exception of some algae, microsporidia, and protists. By virtue of its capacity to produce branched actin filament networks, the complex plays a crucial part in a wide range of cellular processes, including lamellipodia-mediated cell migration, endocytosis, and phagocytosis.
Interaction with actin nucleation-promoting factors (NPFs) is necessary for Arp2/3 activation. Endogenous inhibitory proteins can directly bind to Arp2/3 and compete with NPFs to control its activity, or they can bind to Arp2/3-induced actin filaments and cause branched actin networks to disassemble. Since Arp2/3 inhibition has been linked to reduced cancer progression, neurotoxic side effects from drug abuse, and pathogen invasion of host cells, it has recently attracted more attention.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V53210 | 187-1, N-WASP inhibitor | 380488-27-7 | 187-1, N-WASP inhibitor is a 14-aa cyclic peptide and an allosteric neurological Wiskott Aldrich syndrome protein (N-WASP) inhibitor. |
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V77517 | 187-1, N-WASP inhibitor TFA | 187-1, N-WASP inhibitor TFA is a 14-aa cyclic peptide and an allosteric neuro-Wiskott Aldrich syndrome protein (N-WASP) inhibitor. | |
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V75799 | Benproperine phosphate | 19428-14-9 | Benproperine phosphate is an orally bioactive and potent inhibitor of actin-associated protein 2/3 complex subunit 2 (ARPC2). |
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V3745 | CK-869 | 388592-44-7 | CK-869 is a small molecule inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex whichis a seven-subunit assembly that nucleates branched actin filaments. |
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V52135 | EG-011 | 2377113-41-0 | EG-011 is a first-in-class, potent activator of Wiskott-Aldrich syndrome protein (WASP). |
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V53241 | Fequesetide | 476014-70-7 | Fequesetide is a bioactive peptide that is the active site of thymosin-regulated protein β4, responsible for actin binding, cell migration, and wound healing. |
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V56036 | Phallacidin (carboxydihydroxyphalloidin) | 26645-35-2 | Phallacidin is a member of the phalloidin family of mushroom toxins. |
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V50922 | Wiskostatin | 253449-04-6 | Wiskostatin is a potent and specific activator of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. |
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